Circulating Tumor DNA and Radiological Tumor Volume Identify Patients at Risk for Relapse With Resected, Early-Stage Non-Small-Cell Lung Cancer

Authors

H T Tran
S Heeke
S Sujit
N Vokes
J Zhang
M Aminu
V K Lam
A Vaporciyan
S G Swisher
M C B Godoy
T Cascone
B Sepesi
D L Gibbons
J Wu
J V Heymach

Publication Date

2-1-2024

Journal

Annals of Oncology

DOI

10.1016/j.annonc.2023.11.008

PMID

37992871

PMCID

PMC11233158

PubMedCentral® Posted Date

2-1-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Background: Predicting relapse and overall survival (OS) in early-stage non-small-cell lung cancer (NSCLC) patients remains challenging. Therefore, we hypothesized that detection of circulating tumor DNA (ctDNA) can identify patients with increased risk of relapse and that integrating radiological tumor volume measurement along with ctDNA detectability improves prediction of outcome.

Patients and methods: We analyzed 366 serial plasma samples from 85 patients who underwent surgical resections and assessed ctDNA using a next-generation sequencing liquid biopsy assay, and measured tumor volume using a computed tomography-based three-dimensional annotation.

Results: Our results showed that patients with detectable ctDNA at baseline or after treatment and patients who did not clear ctDNA after treatment had a significantly worse clinical outcome. Integrating radiological analysis allowed the stratification in risk groups prognostic of clinical outcome as confirmed in an independent cohort of 32 patients.

Conclusions: Our findings suggest ctDNA and radiological monitoring could be valuable tools for guiding follow-up care and treatment decisions for early-stage NSCLC patients.

Keywords

Humans, Circulating Tumor DNA, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Tumor Burden, Mutation, Small Cell Lung Carcinoma, Recurrence, Biomarkers, Tumor

Published Open-Access

yes

Recommended Citation

Tran, H T; Heeke, S; Sujit, S; et al., "Circulating Tumor DNA and Radiological Tumor Volume Identify Patients at Risk for Relapse With Resected, Early-Stage Non-Small-Cell Lung Cancer" (2024). Faculty, Staff and Student Publications. 4430.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4430