Therapeutic Targeting of Hypoxia Inducible Factor in Acute Respiratory Distress Syndrome

Authors

Thu T Tran
Holger K Eltzschig
Xiaoyi Yuan

Publication Date

11-1-2024

Journal

The Journal of Physiology

DOI

10.1113/JP284599

PMID

38031820

PMCID

PMC11136894

PubMedCentral® Posted Date

11-1-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Acute respiratory distress syndrome (ARDS) is characterized by bilateral chest infiltration and acute hypoxic respiratory failure. ARDS carries significant morbidity and mortality despite advancements in medical management, calling for the development of novel therapeutic targets. Hypoxia-inducible factor (HIF) is a heterodimeric protein involved in various essential pathways, including metabolic reprogramming, immune modulation, angiogenesis and cell cycle regulation. HIF is routinely degraded in homeostasis conditions via the prolyl hydroxylase domain/von Hippel-Lindau protein pathway. However, HIF is stabilized in ARDS via various mechanisms (oxygen-dependent and independent) as an endogenous protective pathway and plays multifaceted roles in different cell populations. This review focuses on the functional role of HIF and its target genes during ARDS, as well as how HIF has evolved as a therapeutic target in current medical management.

Keywords

Humans, Respiratory Distress Syndrome, Animals, Hypoxia-Inducible Factor 1, ARDS, HIF, hypoxia signalling, target genes

Published Open-Access

yes

Recommended Citation

Thu T Tran, Holger K Eltzschig, and Xiaoyi Yuan, "Therapeutic Targeting of Hypoxia Inducible Factor in Acute Respiratory Distress Syndrome" (2024). Faculty, Staff and Student Publications. 5618.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5618