Faculty, Staff and Student Publications
Publication Date
7-1-2024
Journal
Seminars in Radiation Oncology
DOI
10.1016/j.semradonc.2024.04.008
PMID
38880544
PMCID
PMC12313220
PubMedCentral® Posted Date
7-31-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
The "FLASH effect" is an increased therapeutic index, that is, reduced normal tissue toxicity for a given degree of anti-cancer efficacy, produced by ultra-rapid irradiation delivered on time scales orders of magnitude shorter than currently conventional in the clinic for the same doses. This phenomenon has been observed in numerous preclinical in vivo tumor and normal tissue models. While the underlying biological mechanism(s) remain to be elucidated, a path to clinical implementation of FLASH can be paved by addressing several critical translational questions. Technological questions pertinent to each beam type (eg, electron, proton, photon) also dictate the logical progression of experimentation required to move forward in safe and decisive clinical trials. Here we review the available preclinical data pertaining to these questions and how they may inform strategies for FLASH cancer therapy clinical trials.
Keywords
Humans, Neoplasms, Translational Research, Biomedical, Animals, Radiation Oncology, Clinical Trials as Topic
Published Open-Access
yes
Recommended Citation
Loo, Billy W; Verginadis, Ioannis I; Sørensen, Brita Singers; et al., "Navigating the Critical Translational Questions for Implementing FLASH in the Clinic" (2024). Faculty, Staff and Student Publications. 4616.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4616
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