90Y SIR-Spheres Activity Measurement with New SIROS D-Vial Delivery Kit

Authors

Benjamin P Lopez
S Cheenu Kappadath

Language

English

Publication Date

9-5-2024

Journal

Journal of Nuclear Medicine Technology

DOI

10.2967/jnmt.124.267413

PMID

39019573

Abstract

A new 90Y SIR-Spheres delivery kit (SIROS D-vial and shield) has been introduced with a different physical form from the legacy V-Vial kit. Here, we establish the dose calibrator settings and exposure-rate-to-activity conversion factor to assay 90Y SIR-Spheres activity in the new SIROS kit.

Methods: Eight D-vials with initial 90Y activities from 1.2 to 6.6 GBq within acrylic shields were assayed with dose calibrators and exposure-rate meters until activities decayed to approximately 0.1 GBq. The dose calibrator settings resulting in the lowest median activity errors and the best-fit slope of exposure rate versus activity were identified.

Results: SIROS D-vial 90Y activity can be accurately and reliably estimated directly using setting 51 × 10 on both the CRC-15R and the CRC-55tR dose calibrators (errors within ±0.5%) and indirectly with an exposure-rate reading at 30 cm using conversion factor 0.664 ± 0.003 GBq/(mR/h) (R 2 = 0.985).

Conclusion: Dose calibrator settings and exposure-rate-to-activity conversion factor for 90Y activity assays with new SIROS kit should be updated from legacy V-Vial parameters to avoid an approximately 10% underestimation.

Keywords

Calibration, Yttrium Radioisotopes, Radiometry, Microspheres, 90Y microspheres, SIR-Spheres, SIROS, dose calibrator, ionization chamber

Published Open-Access

yes

Recommended Citation

Benjamin P Lopez and S Cheenu Kappadath, "90Y SIR-Spheres Activity Measurement with New SIROS D-Vial Delivery Kit" (2024). Faculty, Staff and Student Publications. 5941.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5941