Faculty, Staff and Student Publications
Publication Date
1-1-2024
Journal
Practical Radiation Oncology
DOI
10.1016/j.prro.2024.05.006
PMID
38851534
PMCID
PMC11622145
PubMedCentral® Posted Date
6-1-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
PURPOSE: Soft tissue sarcomas (STSs) of the head and neck (H&N) are rare malignancies that are challenging to manage. We sought to describe the outcomes of patients treated with curative intent using combined surgery and radiation therapy (RT) for H&N STS.
METHODS AND MATERIALS: We performed a single-institution retrospective review of patients with nonmetastatic STS of the H&N who were treated from 1968 to 2020. The Kaplan-Meier method was used to estimate disease-specific survival (DSS) and local control (LC). Multivariable analyses (MVAs) were conducted using Cox proportional hazards model.
RESULTS: One hundred ninety-two patients had a median follow-up of 82 months. Tumors arose in the neck (n = 50, 26%), paranasal sinuses (n = 36, 19%), or face (n = 23, 12%). Most patients were treated with postoperative RT (n = 134, 70%). Postoperative RT doses were higher (median, 60 Gy; preoperative dose, 50 Gy; P < .001). Treatment sequence was not associated with LC (preoperative RT, 78% [63%-88%]; postoperative RT, 75% [66%-82%]; P = .48). On MVA, positive/uncertain margin was the only variable associated with LC (hazard ratio [HR], 2.54; 95% CI, 1.34-4.82; P = .004). LC was significant on MVA (HR, 4.48; 95% CI, 2.62-7.67; P < .001) for DSS. Patients who received postoperative RT were less likely to experience a major wound complication (7.5% vs 22.4%; HR, 0.28; 95% CI, 0.11-0.68; P = .005). There was no difference in the rate of late toxicities between patients who received preoperative or postoperative RT.
CONCLUSIONS: H&N STS continues to have relatively poorer LC than STS of the trunk or extremities. We found LC to be associated with DSS. Timing of RT did not impact oncologic or long-term toxicity outcomes; however, preoperative RT did increase the chance of developing a major wound complication.
Keywords
Humans, Male, Sarcoma, Female, Head and Neck Neoplasms, Middle Aged, Retrospective Studies, Aged, Adult, Aged, 80 and over, Young Adult, Adolescent, Treatment Outcome, Combined Modality Therapy
Published Open-Access
yes
Recommended Citation
Yoder, Alison K; Farooqi, Ahsan; Mitra, Devarati; et al., "Outcomes for Patients With Head and Neck Sarcoma Treated Curatively With Radiation Therapy and Surgery" (2024). Faculty, Staff and Student Publications. 4837.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4837
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