Faculty, Staff and Student Publications
Publication Date
12-1-2023
Journal
Modern Pathology
DOI
10.1016/j.modpat.2023.100349
PMID
37820764
Abstract
A small subset of high-grade B-cell lymphoma (HGBL) with blastoid morphology remains poorly understood. We assessed 55 cases of blastoid HGBL, not otherwise specified (NOS) and compared their clinicopathologic characteristics with those of 81 non-blastoid HGBL-NOS and 62 blastoid HGBL with MYC and BCL2, with or without BCL6 rearrangements (double/triple-hit lymphoma [D/THL]). Patients with blastoid HGBL-NOS showed similar clinicopathologic features to patients with blastoid D/THLs and non-blastoid HGBL-NOS, except more frequently with a history of low-grade B-cell lymphoma, bone marrow involvement, and BCL2 rearrangement (P < .05) compared to the latter. MYC rearrangement (MYC-R), detected in 40% of blastoid HGBL-NOS, was associated with aggressive clinicopathologic features and poorer overall survival, even worse than that of blastoid D/THL (P < .05). Transcriptome profiling revealed a distinct gene expression pattern with differentially expressed genes enriched in MYC and P53-targeted genes in MYC-R blastoid HGBL-NOS. Fifty-two percent of blastoid HGBL-NOS had a double hit-like signature, similar to non-blastoid HGBL-NOS (P = .73). The overall survival of the blastoid HGBL-NOS group was similar to that of the blastoid D/THL group but appeared poorer than that of its non-blastoid counterparts (P = .07). Taken together, blastoid HGBL-NOS is an aggressive B-cell lymphoma that shares overlapping clinicopathologic and genetic features with non-blastoid HGBL-NOS. MYC-R in patients with blastoid HGBL-NOS identifies a highly aggressive subgroup with distinct aggressive clinicopathologic features, unique molecular signatures, and a dismal clinical outcome.
Keywords
Humans, Gene Rearrangement, Lymphoma, B-Cell, Proto-Oncogene Proteins c-myc, Biomarkers, Tumor, Proto-Oncogene Proteins c-bcl-2, Lymphoma, Large B-Cell, Diffuse, Proto-Oncogene Proteins c-bcl-6, MYC rearrangement, blastoid morphology, clinicopathologic features, double/triple-hit lymphoma, high-grade B-cell lymphoma, not otherwise specified, transcriptome profile
Published Open-Access
yes
Recommended Citation
Qiu, Lianqun; Lin, Pei; Khanlari, Mahsa; et al., "The Clinicopathologic Features and Molecular Signatures of Blastoid High-Grade B Cell Lymphoma, Not Otherwise Specified" (2023). Faculty, Staff and Student Publications. 5168.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5168
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