Faculty, Staff and Student Publications
Language
English
Publication Date
6-2-2025
Journal
Genes & Development
DOI
10.1101/gad.352932.125
PMID
40345854
PMCID
PMC12128862
PubMedCentral® Posted Date
6-1-2025
PubMedCentral® Full Text Version
Post-print
Abstract
In this Outlook, Huang et al. discuss a study in this issue of Genes & Development by Fraire et al. that shows that a deficiency in miRNA processors Drosha and Dicer and consequent cell cycle gene derepression promote pineoblastoma development. The authors highlight the heterogeneity of pineoblastoma's pathogenic mechanisms and its implications for therapeutic interventions in the clinic.
Keywords
Ribonuclease III, Animals, Pinealoma, Humans, Mice, Pineal Gland, MicroRNAs, Genes, Tumor Suppressor, DEAD-box RNA Helicases, Gene Expression Regulation, Neoplastic, Brain Neoplasms, Disease Models, Animal, Dicer1, Drosha, microRNA, pineoblastoma
Published Open-Access
yes
Recommended Citation
Zhixuan Huang, Xueli Ren, and Jian Hu, "Drosha: A New Tumor Suppressor in Pineoblastoma" (2025). Faculty, Staff and Student Publications. 5867.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5867
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