Faculty, Staff and Student Publications

Language

English

Publication Date

11-15-2025

Journal

The Neuroradiology Journal

DOI

10.1177/19714009251395689

PMID

41239912

PMCID

PMC12619698

PubMedCentral® Posted Date

11-15-2025

PubMedCentral® Full Text Version

Post-print

Abstract

High-grade astrocytoma with piloid features (HGAP) is a recently described IDH-wildtype tumor with limited literature describing its imaging features. We present our institution's experience and the largest imaging-focused cohort of HGAP reported to date, offering a comprehensive analysis of MRI features of seventeen intracranial and one spinal HGAP, while introducing novel imaging features that have not been previously described. These include focal areas of diffusion restriction, surrounding spiculated, finger-like enhancement and increased perfusion metrics. Additionally, we highlight imaging features of HGAP arising in patients with Neurofibromatosis Type 1, such as intraventricular tumor spread, unusual temporal lobe location and multifocal presentation.

Keywords

High-grade astrocytoma with piloid features, novel imaging features, focal diffusion restriction, perilesional spiculated, finger-like enhancement, neurofibromatosis type 1, ependymal enhancement

Published Open-Access

yes

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