Identification of Minimum Essential Therapeutic Mixtures From Cannabis Plant Extracts by Screening in Cell and Animal Models of Parkinson’s Disease

Authors

Michael G Morash
Jessica Nixon
Lori M N Shimoda
Helen Turner
Alexander J Stokes
Andrea L Small-Howard
Lee D Ellis

Publication Date

10-5-2022

Journal

Frontiers in Pharmacology

Abstract

Medicinal cannabis has shown promise for the symptomatic treatment of Parkinson's disease (PD), but patient exposure to whole plant mixtures may be undesirable due to concerns around safety, consistency, regulatory issues, and psychoactivity. Identification of a subset of components responsible for the potential therapeutic effects within cannabis represents a direct path forward for the generation of anti-PD drugs. Using an

Keywords

Parkinson’s disease, cannabinoids, zebrafish, dopamine, neuroprotection, movement disorder, cannabis, cannabidiol

Comments

Supplementary Material

PMID: 36278152

DOI

10.3389/fphar.2022.907579

PMID

36278152

PMCID

PMC9586206

PubMedCentral® Posted Date

October 2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes