Transiently Impaired Endothelial Function During Thyroid Hormone Withdrawal in Differentiated Thyroid Cancer Patients

Authors

Li-Ying Hou
Xiao Li
Guo-Qiang Zhang
Chuang Xi
Chen-Tian Shen
Hong-Jun Song
Wen-Kun Bai
Zhong-Ling Qiu
Quan-Yong Luo

Publication Date

1-1-2023

Journal

Frontiers in Endocrinology

Abstract

PURPOSE: Endothelial dysfunction, which was associated with chronic hypothyroidism, was an early event in atherosclerosis. Whether short-term hypothyroidism following thyroxine withdrawal during radioiodine (RAI) therapy was associated with endothelial dysfunction in patients with differentiated thyroid cancer (DTC) was unclear. Aim of the study was to assess whether short-term hypothyroidism could impair endothelial function and the accompanied metabolic changes in the whole process of RAI therapy.

METHODS: We recruited fifty-one patients who underwent total thyroidectomy surgery and would accept RAI therapy for DTC. We analyzed thyroid function, endothelial function and serum lipids levels of the patients at three time points: the day before thyroxine withdrawal(P

RESULTS: We analyzed the changes of FMD, thyroid function and lipids at three time points. FMD(P

CONCLUSION: Endothelial function was transiently impaired in DTC patients at short-term hypothyroidism state during the RAI therapy, and immediately returned to the initial state after restoring TSH suppression therapy.

Keywords

Humans, Thyroxine, Iodine Radioisotopes, Thyroid Neoplasms, Hypothyroidism, Adenocarcinoma, Lipoproteins, LDL

Comments

PMID: 37424871