Content Posted in 2025
Whole-Transcriptome Sequencing-Based Profiling of the Cutaneous Virome in Patients with Secondary Immunodeficiency, Leila Youssefian, Amir Hossein Saeidian, Zahra Saffarian, Mona Ariamanesh, Fahimeh Abdollahimajd, Sara Molkara, Mohammad Shahidi-Dadras, Reem Diab, Fatemeh Vahidnezhad, Sirous Zeinali, Vivien Béziat, Emmanuelle Jouanguy, Jean-Laurent Casanova, Jouni Uitto, and Hassan Vahidnezhad
Why Animal Experiments Are Still Indispensable in Bone Research: A Statement by the European Calcified Tissue Society, Merle Stein, Florent Elefteriou, Björn Busse, Imke Ak Fiedler, Ronald Young Kwon, Eric Farrell, Mubashir Ahmad, Anita Ignatius, Liam Grover, Liesbet Geris, and Jan Tuckermann
Why Does the Cost of Employer-Sponsored Coverage Keep Rising?, Salpy Kanimian and Vivian Ho
Why Do Patients With Cancer Die?, Adrienne Boire, Katy Burke, Thomas R Cox, Theresa Guise, Mariam Jamal-Hanjani, Tobias Janowitz, Rosandra Kaplan, Rebecca Lee, Charles Swanton, Matthew G Vander Heiden, and Erik Sahai
Why Do Patients With Cancer Die?, Adrienne Boire, Katy Burke, Thomas R Cox, Theresa Guise, Mariam Jamal-Hanjani, Tobias Janowitz, Rosandra Kaplan, Rebecca Lee, Charles Swanton, Matthew G Vander Heiden, and Erik Sahai
Why Study Mechanisms of Brain Stimulation Therapies? To Modulate the Right Neurons, in the Right Way, at the Right Time, Matthew J McGinley and Steven T Lee
Why the Vonoprazan Helicobacter pylori Therapies in the US-European Trial Produced Unacceptable Cure Rates, David Y Graham
Wide Range of Phenotypic Severity in Individuals With Late Truncations Unique to the Predominant CDKL5 Transcript in the Brain, Laura Keehan, Isabel Haviland, Yoel Gofin, Lindsay C Swanson, Christelle Moufawad El Achkar, John Schreiber, Grace E VanNoy, Emily O'Heir, Anne O'Donnell-Luria, Richard Alan Lewis, Pilar Magoulas, Alyssa Tran, Mahshid S Azamian, Hsiao-Tuan Chao, Lisa Pham, Rodney C Samaco, Sarah Elsea, Erin Thorpe, Akanchha Kesari, Denise Perry, Brendan Lee, Seema R Lalani, Jill A Rosenfeld, Heather E Olson, and Lindsay C Burrage
Will Anti-vaccine Activism in the USA Reverse Global Goals?, Peter J Hotez
Will You Go the Distance? A Satisfaction Survey of Telemedicine in Sexual Medicine, Gal Saffati, Taher Naeem, Jordan Kassab, Daniela Orozco Rendon, Charles Green, Larry I Liphsultz, and Mohit Khera
Windows into the McGovern Historical Center, Matt Richardson
Wirelessly Actuated Microfluidic Pump and Valve for Controlled Liquid Delivery in Dental Implants, Yilan Xu, Honglu Lin, Boyang Xiao, Hutomo Tanoto, Joel Berinstein, Alend Khoshnaw, Simon Young, Yuxiao Zhou, and Xiaoguang Dong
Wire Snare Close Loop: A Novel Technique to Retrieve Embolized Devices, Manish Bansal, Gary E Stapleton, Srinath T Gowda, and Athar M Qureshi
Wnk Kinase Is a Vasoactive Chloride Sensor in Endothelial Cells, Tessa A C Garrud, Briar Bell, Alejandro Mata-Daboin, Dieniffer Peixoto-Neves, Daniel M Collier, Julio F Cordero-Morales, and Jonathan H Jaggar
WNT4 Deficiency Impacts Heart, Diaphragm, and Palate Development: Insights From Human Genetics, Machine Learning, and Mouse Models, Andrés Hernández-García, Bum Jun Kim, David Chitayat, Patrick Shannon, Stephanie Hedges, Maria Al Bandari, Maria J Guillen Sacoto, Emily Anne Bates, Yunus H Ozekin, Victor Faundes, Pamela N Luna, Chad A Shaw, Tara L Rasmussen, Chih-Wei Hsu, and Daryl A Scott
Wnt-Directed CXCL12-Expressing Apical Papilla Progenitor Cells Drive Tooth Root Formation, Mizuki Nagata, Gaurav T Gadhvi, Taishi Komori, Yuki Arai, Hiroaki Manabe, Angel Ka Yan Chu, Ramandeep Kaur, Meer Ali, Yuntao Yang, Chiaki Tsutsumi-Arai, Yuta Nakai, Yuki Matsushita, Nicha Tokavanich, W Jim Zheng, Joshua D Welch, Noriaki Ono, and Wanida Ono
Woman's Dictation (Likely Hilde Bruch), Part 1 of 1, Hilde Bruch 1904-1984
Women and Kidney Health: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference., Giorgina Barbara Piccoli, Sofia B Ahmed, Fadi Fakhouri, Vesna D Garovic, Michelle A Hladunewich, Shilpanjali Jesudason, Jai Prakash, Angela C Webster, Elena Zakharova, Michael Cheung, Jennifer M King, Michel Jadoul, Wolfgang C Winkelmayer, and Christina M Wyatt
Women’s Health and Kidney Protective Medications, Mythri Shankar, Sehrish Ali, and Silvi Shah
Work as a Social Determinant of Maternal Health: A Qualitative Exploration of College-Educated Black Women’s Experiences at Work During Pregnancy and Postpartum, Serwaa S Omowale, Laurenia C Mangum, Andrea Joseph-McCatty, Cherell Cottrell-Daniels, Kaiya A Farris, Rashon King, and Brittany C Slatton
Work Where You Live or Live Where You Work? Resident Work and Sleep Patterns While on "Home Call", David T Mitchell, Noa G Koppin, Michael T Talanker, Mohin A Bhadkamkar, Erik S Marques, Matthew R Greives, and David C Hopkins
Work Where You Live or Live Where You Work? Resident Work and Sleep Patterns While on "Home Call", David T Mitchell, Noa G Koppin, Michael T Talanker, Mohin A Bhadkamkar, Erik S Marques, Matthew R Greives, and David C Hopkins
World-Renowned "Swiss" Pediatricians, Their Syndromes, and Matching Imaging Findings: A Historical Perspective, Laura M Huisman and Thierry A G M Huisman
Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK), Shina Menon, Kelli A Krallman, Ayse A Arikan, Dana Y Fuhrman, Stephen M Gorga, Theresa Mottes, Nicholas Ollberding, Zaccaria Ricci, Natalja L Stanski, David T Selewski, Danielle E Soranno, Michael Zappitelli, Huaiyu Zang, and Katja M Gist
Worldwide Prevalence of Chagas Cardiomyopathy-An Analysis From the Global Burden of Disease Dataset, Abdul Mannan Khan Minhas, Rachel Marcus, Salim S Virani, Michael D Shapiro, Robert J Mentz, Luis E Echeverria, Jonathan T Arcobello, and Dmitry Abramov
Worth a Pound of Cure? Emerging Strategies and Challenges in Cancer Immunoprevention, Saurav D Haldar, Eduardo Vilar, Anirban Maitra, and Neeha Zaidi
Worth a Pound of Cure? Emerging Strategies and Challenges in Cancer Immunoprevention, Saurav D Haldar, Eduardo Vilar, Anirban Maitra, and Neeha Zaidi
Wrapper-Based Deep Feature Optimization for Activity Recognition in the Wearable Sensor Networks of Healthcare Systems, Karam Kumar Sahoo, Raghunath Ghosh, Saurav Mallik, Arup Roy, Pawan Kumar Singh, and Zhongming Zhao
Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice, Dongju Park, Mehdi Gharghabi, Colleen R Reczek, Rebecca Plow, Charles Yungvirt, C Marcelo Aldaz, and Kay Huebner
xAtlas: Scalable Small Variant Calling Across Heterogeneous Next-Generation Sequencing Experiments, Jesse Farek, Daniel Hughes, William Salerno, Yiming Zhu, Aishwarya Pisupati, Adam Mansfield, Olga Krasheninina, Adam C English, Ginger Metcalf, Eric Boerwinkle, Donna M Muzny, Richard Gibbs, Ziad Khan, and Fritz J Sedlazeck
XBP1s-EDEM2 Prevents the Onset and Development of HFpEF by Ameliorating Cardiac Lipotoxicity, Oveena Fonseka, Rida Raja, Claire Ross, Sanskruti R Gare, Jiayan Zhang, Susanne S Hille, Katharine King, Andrea Ruiz-Velasco, Namrita Kaur, Xinyi Chen, Jessica M Miller, Riham R E Abouleisa, Qinghui Ou, Zhiyong Zou, Xiangjun Zhao, Cristian Sotomayor-Flores, Derk Frank, Eileithyia Swanton, Martin R Pool, Sara Missaglia, Daniela Tavian, Gabriele G Schiattarella, Tao Wang, Luigi Venetucci, Christian Pinali, Martin K Rutter, Bernard D Keavney, Elizabeth J Cartwright, Tamer M A Mohamed, Oliver J Müller, and Wei Liu
XCVATR: Detection and Characterization of Variant Impact on the Embeddings of Single -Cell and Bulk RNA-Sequencing Samples, Arif Harmanci, Akdes Serin Harmanci, Tiemo J Klisch, and Akash J Patel
Xenomake: A Pipeline for Processing and Sorting Xenograft Reads From Spatial Transcriptomic Experiments, Benjamin S Strope, Katherine E Pendleton, William Z Bowie, Gloria V Echeverria, and Qian Zhu
X-Linked Genetic Associations in Sporadic Thoracic Aortic Dissection, Fadi I Musfee, Goo Jun, Laura E Mitchell, Han Chen, Dongchuan Guo, Siddharth K Prakash, Shaunak Sanjay Adkar, Megan L Grove, Ryan Bohyun Choi, Derek Klarin, Million Veteran Program, Eric Boerwinkle, and Dianna M Milewicz
X-Linked Serotonin 2C Receptor Is Associated With a Non-Canonical Pathway for Sudden Unexpected Death in Epilepsy, Cory A Massey, Samantha J Thompson, Ryan W Ostrom, Janice Drabek, Olafur A Sveinsson, Torbjörn Tomson, Elisabeth A Haas, Othon J Mena, Alica M Goldman, and Jeffrey L Noebels
Xpert MTB/RIF Ultra Assay for Tuberculosis Disease and Rifampicin Resistance in Children, Alexander W Kay, Tara Ness, Sabine E Verkuijl, Kerri Viney, Annemieke Brands, Tiziana Masini, Lucia González Fernández, Michael Eisenhut, Anne K Detjen, Anna M Mandalakas, Karen R Steingart, and Yemisi Takwoingi
Years of Life Lost Associated With COVID-19 Deaths in the USA During the First 2 Years of the Pandemic, Troy Quast, Ross Andel, Sean Gregory, and Eric A Storch
Yeast EndoG Prevents Genome Instability by Degrading Extranuclear DNA Species, Yang Yu, Xin Wang, Jordan Fox, Ruofan Yu, Pilendra Thakre, Brenna McCauley, Nicolas Nikoloutsos, Yang Yu, Qian Li, P J Hastings, Weiwei Dang, Kaifu Chen, and Grzegorz Ira
Younger Haplo-Donors Improve Older Patient Survival Outcomes, Ahmad Ghorab and Leo Luznik
YWHAE Loss of Function Causes a Rare Neurodevelopmental Disease With Brain Abnormalities in Human and Mouse, Anne-Sophie Denommé-Pichon, Stephan C Collins, Ange-Line Bruel, Anna Mikhaleva, Christel Wagner, Valerie E Vancollie, Quentin Thomas, Martin Chevarin, Mathys Weber, Carlos E Prada, Alexis Overs, María Palomares-Bralo, Fernando Santos-Simarro, Marta Pacio-Míguez, Tiffany Busa, Eric Legius, Carlos A Bacino, Jill A Rosenfeld, Gwenaël Le Guyader, Matthieu Egloff, Xavier Le Guillou, Maria Antonietta Mencarelli, Alessandra Renieri, Salvatore Grosso, Jonathan Levy, Blandine Dozières, Isabelle Desguerre, Antonio Vitobello, Yannis Duffourd, Christopher J Lelliott, Christel Thauvin-Robinet, Christophe Philippe, Laurence Faivre, and Binnaz Yalcin
Zanidatamab Monotherapy or Combined With Chemotherapy in HER2-Expressing Gastroesophageal Adenocarcinoma: A Phase 1 Trial, Funda Meric-Bernstam, Sun Young Rha, Erika Hamilton, Yoon-Koo Kang, Diana L Hanna, Syma Iqbal, Keun-Wook Lee, Jeeyun Lee, Muralidhar Beeram, Do-Youn Oh, Jorge Chaves, Rachel A Goodwin, Jaffer A Ajani, Lin Yang, Rajen Oza, and Elena Elimova
Zanubrutinib for Treatment-Naïve and Relapsed/Refractory Chronic Lymphocytic Leukaemia: Long-Term Follow-Up of the Phase I/II AU-003 Study, Gavin Cull, Jan A Burger, Stephen Opat, David Gottlieb, Emma Verner, Judith Trotman, Paula Marlton, Javier Munoz, Patrick Johnston, David Simpson, Jennifer C Stern, Radha Prathikanti, Kenneth Wu, William Novotny, Jane Huang, and Constantine S Tam
Zanubrutinib for Treatment-Naïve and Relapsed/Refractory Chronic Lymphocytic Leukaemia: Long-Term Follow-Up of the Phase I/II AU-003 Study, Akash Mukherjee, Denái R Milton, Elias J Jabbour, Alison M Gulbis, Tapan Kadia, Nitin Jain, Celina Ledesma, Jan Burger, Alessandra Ferrajoli, William Wierda, L Jeffrey Medeiros, Hagop Kantarjian, Richard Champlin, and Issa F Khouri
ZEB1 Is Regulated by K811 Acetylation to Promote Stability, NuRD Complex Interactions, EMT, and NSCLC Metastasis, Mabel Perez-Oquendo, Roxsan Manshouri, Yanhua Tian, Jared J Fradette, B Leticia Rodriguez, Samrat T Kundu, and Don L Gibbons
Zero-Inflated Models for the Evaluation of Colorectal Polyps in Colon Cancer Screening Studies-A Value-Based Biostatistics Practice, Alok K Dwivedi, Sherif E Elhanafi, Mohamed O Othman, and Marc J Zuckerman
ZIC1 Is a Context-Dependent Medulloblastoma Driver in the Rhombic Lip, John J Y Lee, Ran Tao, Zhen You, Parthiv Haldipur, Anders W Erickson, Hamza Farooq, Liam D Hendriske, Namal Abeysundara, Cory M Richman, Evan Y Wang, Neha Das Gupta, Jennifer Hadley, Melissa Batts, Christopher W Mount, Xiaochong Wu, Alex Rasnitsyn, Swneke Bailey, Florence M G Cavalli, Sorana Morrissy, Livia Garzia, Kulandaimanuvel Antony Michealraj, Abhi Visvanathan, Vernon Fong, Jonelle Palotta, Raul Suarez, Bryn G Livingston, Miao Liu, Betty Luu, Craig Daniels, James Loukides, Anne Bendel, Pim J French, Johan M Kros, Andrey Korshunov, Marcel Kool, Fernando Chico Ponce de León, Mario Perezpeña-Diazconti, Boleslaw Lach, Sheila K Singh, Sarah E S Leary, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Ji-Yeoun Lee, Teiji Tominaga, William A Weiss, Joanna J Phillips, Shizhong Dai, Gelareh Zadeh, Ali G Saad, László Bognár, Almos Klekner, Ian F Pollack, Ronald L Hamilton, Young-Shin Ra, Wieslawa A Grajkowska, Marta Perek-Polnik, Reid C Thompson, Anna M Kenney, Michael K Cooper, Stephen C Mack, Nada Jabado, Mathieu Lupien, Marco Gallo, Vijay Ramaswamy, Mario L Suva, Hiromichi Suzuki, Kathleen J Millen, L Frank Huang, Paul A Northcott, and Michael D Taylor
Zika Virus Co-Opts microRNA Networks To Persist in Placental Niches Detected by Spatial Transcriptomics, Enrico R Barrozo, Maxim D Seferovic, Mark P Hamilton, David N Moorshead, Michael D Jochum, Trang Do, Derek S O'Neil, Melissa A Suter, and Kjersti M Aagaard
Zika Virus NS1 Drives Tunneling Nanotube Formation for Mitochondrial Transfer and Stealth Transmission in Trophoblasts, Rafael T Michita, Long B Tran, Steven J Bark, Deepak Kumar, Shay A Toner, Joyce Jose, Indira U Mysorekar, and Anoop Narayanan
Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-Driven Cancers, Birgit Wilding, Lydia Woelflingseder, Anke Baum, Krzysztof Chylinski, Gintautas Vainorius, Neil Gibson, Irene C Waizenegger, Daniel Gerlach, Martin Augsten, Fiona Spreitzer, Yukina Shirai, Masachika Ikegami, Sylvia Tilandyová, Dirk Scharn, Mark A Pearson, Johannes Popow, Anna C Obenauf, Noboru Yamamoto, Shunsuke Kondo, Frans L Opdam, Annemarie Bruining, Shinji Kohsaka, Norbert Kraut, John V Heymach, Flavio Solca, and Ralph A Neumüller
ZRANB1 Is an NBS1 Deubiquitinase and a Potential Target To Overcome Radioresistance and PARP Inhibitor Resistance in Triple-Negative Breast Cancer, Ying Mei, Qinglei Hang, Hongqi Teng, Fan Yao, Mei-Kuang Chen, Mien-Chie Hung, Yutong Sun, and Li Ma
Z-Scores Outperform Similar Methods for Analyzing CRISPR Paralog Synthetic Lethality Screens, Juihsuan Chou, Nazanin Esmaeili Anvar, Reem Elghaish, Junjie Chen, and Traver Hart
β-Actin G342D as a Cause of NK Cell Deficiency Impairing Lytic Synapse Termination, Abigail E Reed, Jackeline Peraza, Frederique van den Haak, Evelyn R Hernandez, Richard A Gibbs, Ivan K Chinn, James R Lupski, Enrica Marchi, Ran Reshef, Bachir Alobeid, Emily M Mace, and Jordan S Orange
β-Adrenergic Signaling in Skin Cancer, Jennifer Batalla-Covello, Shahrukh Ali, Tongxin Xie, and Moran Amit
β-Carotene Oxygenase 2 Genotype Modulates the Impact of Dietary Lycopene on Gene Expression during Early TRAMP Prostate Carcinogenesis., Nancy E Moran, Jennifer M Thomas-Ahner, Joshua W Smith, Ceasar Silva, Noor A Hason, John W Erdman, and Steven K Clinton
β-Catenin Drives the FOXC2-Mediated Epithelial-Mesenchymal Transition and Acquisition of Stem Cell Properties, Maria Castaneda, Petra den Hollander, Steve Werden, Esmeralda Ramirez-Peña, Suhas V Vasaikar, Nick A Kuburich, Claire Gould, Rama Soundararajan, and Sendurai A Mani
β-Cell Impairment and Clinically Meaningful Alterations in Glycemia in Obese Youth Across the Glucose Tolerance Spectrum, Joon Young Kim, Hala Tfayli, Fida Bacha, SoJung Lee, Nour Gebara, and Silva Arslanian
βII-Spectrin Is Required for Synaptic Positioning during Retinal Development, Debalina Goswami-Sewell, Caitlin Bagnetto, Cesiah C Gomez, Joseph T Anderson, Akash Maheshwari, and Elizabeth Zuniga-Sanchez
βIV Spectrin Abundancy, Cellular Distribution and Sensitivity to AKT/GSK3 Regulation in Schizophrenia, Jessica Di Re, Michela Marini, Syed Ibrar Hussain, Aditya K Singh, Akshaya Venkatesh, Musaad A Alshammari, Tahani K Alshammari, Abdul-Rizaq Ali Hamoud, Ali Sajid Imami, Zahra Haghighijoo, Nickolas Fularcyzk, Laura Stertz, Derek Hawes, Angela Mosebarger, Jordan Jernigan, Claire Chaljub, Ralda Nehme, Consuelo Walss-Bass, Anton Schulmann, Marquis P Vawter, Robert McCullumsmith, Robert D Damoiseaux, Agenor Limon, Demetrio Labate, Michael F Wells, and Fernanda Laezza
ΔFosB Is Part of a Homeostatic Mechanism That Protects the Epileptic Brain From Further Deterioration, Jerome Clasadonte, Tania Deprez, Gabriel S Stephens, Georges Mairet-Coello, Pierre-Yves Cortin, Maxime Boutier, Aurore Frey, Jeannie Chin, and Marek Rajman
ΔNp63 Regulates a Common Landscape of Enhancer Associated Genes in Non-Small Cell Lung Cancer, Marco Napoli, Sarah J Wu, Bethanie L Gore, Hussein A Abbas, Kyubum Lee, Rahul Checker, Shilpa Dhar, Kimal Rajapakshe, Aik Choon Tan, Min Gyu Lee, Cristian Coarfa, and Elsa R Flores