Open-access, full-text copies of The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences dissertations from 2009 onwards. Topics include all aspects of the biomedical sciences.

Authors who expect to publish do have the option to withhold full text for a limited period of time. When that has been done, the reader will see a release date posted with the abstract.

Older GSBS dissertations (from approximately 1979-1999) are available, in print format only, at McGovern Historical Center. They can be found via OneSearch. Search by subject heading: "Dissertations, Academic--University of Texas Health Science Center at Houston. Graduate School of Biomedical Sciences" for the full list, click DigitalCommons@TMC in the white banner above the search box, or use the main search box to search for known individual dissertations.

Some older GSBS dissertations are also available online via ProQuest, but full-text access is restricted to TMC academic institutions affiliated with The TMC Library.

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Theses/Dissertations from 2022

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Absolute Quantification of Tc-99m Activity Distributions Using a Planar Molecular Breast Imaging Commercial System, Benjamin P. Lopez

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A MICROFLUIDICS-BASED APPROACH FOR ISOLATION OF ANTIGEN-SPECIFIC CD8+ T CELLS, Meredith Frank

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Analysis of Huntington Disease Caregiver Quality of Life Using the Enroll-HD Population, Emilyn Banfield

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Analysis of the Distributed Representation of Operant Memory in Aplysia, Renan Murillo Costa

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An Investigation of Epigenetic Mechanisms Driving the Biology of Head and Neck Squamous Cell Carcinoma, Scot Carson Callahan

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Assessing the Impact of Camp PHEver on Blood Phenylalanine Levels, Michelle Zelnick

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ATR-MEDIATED CD47 AND PD-L1 UPREGULATION RESTRICTS RADIOTHERAPY-INDUCED IMMUNE PRIMING AND ABSCOPAL RESPONSES IN COLORECTAL CANCER, Cheng-En Hsieh and Cheng-En Hsieh

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Bayesian Adaptive Designs for Proof-of-Concept Trials and Platform Trials, Yujie Zhao

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BHLHE40: Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy, Avery Salmon and Avery J. Salmon

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Body temperature and diet as drivers of obesity development, Jessie Morrill

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Cell-free DNA Sequencing in Multiple Myeloma, Russell Irwin

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Clinical Impact of a Highly Sensitive Next-Generation Sequencing Measurable Residual Disease Assay in Patients with Acute Lymphoblastic Leukemia, Nicholas Short

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COMPUTATIONAL APPROACHES TO UNDERSTAND CHEMORESISTANCE & TUMOR EVOLUTION USING LONGITUDINAL CLINICAL DATA AND LINEAGE TRACING, Sahil Seth

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Decoding Copy Number Substructure and Evolution from Single Cell Genomics, Darlan Conterno Minussi

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Decoding the Tumor and Immune Microenvironment in PDAC and Breast Cancer by Single Cell Sequencing., Aislyn Schalck

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DEFINING THE COOPERATION BETWEEN MHC-I AND MHC-II NEOANTIGEN-DRIVEN T CELL RESPONSES TO DEVELOP EFFECTIVE PERSONALIZED IMMUNOTHERAPIES, Charmelle Williams

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Development and Characterization of B7-H3-Targeted Radioimmunotherapies for the Treatment of Solid Tumors, Sarah Glazer

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Development of Advanced MR-Guided Adaptive Radiation Therapy Methods for Head & Neck Cancers on the 1.5T MR-Linac, Brigid McDonald

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Development of Graphical Models and Statistical Physics Motivated Approaches to Genomic Investigations, Yashwanth Lagisetty

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DEVELOPMENT OF THE ARK ASSAY FOR QUANTITATING DNA- PROTEIN CROSSLINK ACCUMULATION AND FANCONI ANEMIA PATHWAY INVOLVEMENT IN THE REPAIR PROCESS, Naeh Klages-Mundt

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DOXORUBICIN-INDUCED CARDIOTOXICITY IS MEDIATED BY NEUTROPHILS THROUGH RELEASE OF NEUTROPHIL ELASTASE, Anchit Bhagat

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EFFICACY OF DUAL CD19-CD79b CAR IN B-CELL MALIGNANCIES, Xiaoyun Cheng

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EXPERIENCES OF RACIAL AND ETHNIC MINORITY PATIENTS WITH GENETIC COUNSELING, Emile Moura Coelho da Silva

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EXPLOITING CHEMOGENETIC AND GENETIC INTERACTIONS IN HUMAN CELLS AS AN AVENUE FOR NEW THERAPEUTIC OPPORTUNITIES, Medina Colic

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Genomewide CRISPR/Cas9 Screen Identifies Network of Protein Complexes that Regulate TRIM24, Lalit Patel

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GRK3 CONNECTS ANGIOGENESIS AND NEUROENDOCRINE DIFFERENTIATION IN PROSTATE CANCER BY ACTIVATING HDAC2 THAT EPIGENETICALLY REPRESSES TSP1 AND REST, Samira Naderinezhad

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HAPLOTYPE-INFORMED ALLELIC IMBALANCE DETECTION FROM RNA IN CANCER, Zuhal Ozcan

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HDAC6 INHIBITION REVERSES LONG-TERM DOXORUBICIN-INDUCED COGNITIVE DYSFUNCTION BY RESTORING MICROGLIA HOMEOSTASIS, Blake McAlpin

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HEPATOCELLULAR CARCINOMA IMAGE-GUIDED INTERVENTION: QUANTITATIVE CHARACTERIZATION OF REAGENTS FOR THERMOCHEMICAL ABLATION, Emily A. Thompson

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Impact of brain state on visual and prefrontal population coding in behaving animals, Russell Milton

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Induced Cytotoxicity in CREBBP/EP300mut Head and Neck Squamous Cell Carcinoma, Thomaia Pamplin

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INFRASTRUCTURE DEVELOPMENT FOR PERSONALIZED RISK PREDICTION TO REDUCE CARDIOVASCULAR DISEASE IN CHILDHOOD CANCER SURVIVORS, Suman Shrestha

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Innate lymphoid cell characterization and ILC2s in neuroinflammation in aging and sex differences, Alexis Mobley and Alexis S. Mobley

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INTEGRATION OF BIOMEDICAL IMAGING AND TRANSLATIONAL APPROACHES FOR MANAGEMENT OF HEAD AND NECK CANCER, Abdallah Mohamed and Abdallah Mohamed

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Integrin-Mediated Mechanotransduction Controls Activation of YAP and Invasive Growth of Breast Cancer, Xiaobo Wang

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Investigating the Attitudes of the d/Deaf Community Towards Genetic Counseling and the Utilization of Genetic Services, Katie Baudoin, Jennifer Czerwinski, Laura Farach, Malorie Jones, Rebecca Lunstroth, Caitlin Mauer, and Chelsea Wagner

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INVESTIGATING THE ECOLOGY AND EVOLUTION OF NORMAL BREAST TISSUES AND BREAST CANCER WITH SINGLE CELL GENOMICS, Tapsi Kumar and Tapsi Kumar

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Investigation of Genomic Instability Induced by G-Quadruplexes in the Absence of Functional Topoisomerase 1 in Yeast, Alexandra Berroyer

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Invisible Disabilities, Academic Capital and Competitiveness of Genetic Counseling Applicants, Natalie E. Stoner, Meagan Choates, Carla McGruder, Debra Murray, Theresa Wittman, Sara Wofford, and Claire N. Singletary

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Leveraging single cell technologies for the characterization and treatment of refractory pancreatic cancer, Maria Monberg

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Lipid composition and configuration drive biophysical properties of the mammalian plasma membrane, Jessica L. Symons

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Mechanism of Rare Variant in Acta2, p.Arg149Cys, Driving Diverse Vascular Disease, Kaveeta Kaw

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Modeling of CNS Cancer with a Focus on the Immune Component, Daniel Zamler

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Modulation of KRAS Structure and Dynamics by KRAS Ubiquitination and Membrane Depolarization, Vinay Nair

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Nanoparticles for Biomedical Applications, Joseph Kim

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Non-Invasive Prenatal Screening (NIPS) Testing Motivations and Informed Decision Making in the Low-Risk Population, Jenna Lea

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Non-Photic Mechanisms of Entrainment in BMAL1 Deficient Conditions, Jamie Tran

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NOVEL REGULATORS OF CELLULAR SECRETION ALTER THE TUMOR MICROENVIRONMENT TO DRIVE METASTASIS, Rakhee Bajaj

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Parental Stress in Tuberous Sclerosis Complex, Jenny Do

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Perceptions and Roles of Genetic Counselors in Perinatal Palliative Care: Where Are We Now?, Amanda Chamberlain

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Plant Homeodomain Finger Protein 20 (PHF20) and its Homolog PHF20 Like 1 (PHF20L1) Define Two Distinct Non-Specific Lethal (NSL) Complexes, Hieu Van and Hieu T. Van

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Prenatal Testing Decisions and Motivations in Pregnancies Conceived via In Vitro Fertilization, Michelle Appel

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Quantifying The Magnitude of Total Dose Deviation Caused by Various Sources of Error Among IROC Phantom Irradiation Results, Sharbacha S. Edward

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Redox sensing by yeast Hsp70 facilitates modulation of protein quality control and the cytoprotective response, Alec Santiago

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Regulation of systemic and cellular metabolism in prostate cancer by CAMKK2 and elucidation of ATGL’s role in disease progression, Dominik Awad

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Roles of oxidative stress and DNA methylation in cigarette smoking-induced accelerated acute myeloid leukemia progression, Mary Figueroa

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ROLES OF SMALL RNAS AND PARALOGOUS PROTEINS IN BACILLUS ANTHRACIS VIRULENCE GENE REGULATION, Ileana Corsi

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Statistical Modeling of Longitudinal Medical Cost Data, Shikun Wang

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Status of Abortion Curriculum in Genetic Counseling: Survey of Graduate Programs and Recent Graduates in the United States, Gina Sanchez

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Targeting metabolic adaptations to anti-angiogenic therapy in ovarian cancer, Deanna M. Glassman and Deanna Glassman

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The ADAR-MAVS pathway is a critical mediator of the innate immune system in pancreatic development and cancer, Dhwani Rupani

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THE EFFECT OF COGNITIVE STATUS AND RESIDENCY ON ORAL HEALTH IN PATIENTS WITH DEMENTIA, Nicole Stephens

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THE FUNCTIONAL ROLE OF ANATOMICAL FEEDBACK CONNECTIONS IN VISUAL ATTENTION, Samantha Debes

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The Novel Role of Dnmbp in Kidney Development, Brandy Walker

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THE ROLE AND REGULATION OF ID2 IN DENDRITIC CELLS, Rachel L. Babcock

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The Role of the Hypoxia-Inducible Factor 2 in Pancreatic Cancer: Mechanisms of Tumor Immunosuppression and Intestinal Radioprotection, Carolina Garcia Garcia

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The TCA cycle as a nexus of metabolic vulnerabilities in cancer, Sunada Khadka

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TISSUE-SPECIFIC MATRIX CONTROL OF CELL COHESION AND MIGRATION SIGNALING COMPLEXES, Tristen Tellman

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Understanding and Targeting the Immunosuppressive Tumor Microenvironment, Li Cai and Li Cai

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UNRAVELING THE EFFECTS OF AEROBIC EXERCISE AND ERK5 SIGNALING IN THE SOLID TUMOR MICROENVIRONMENT USING MURINE MODELS, Hannah Savage

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Yap and Taz are Required for Neural Crest-Derived Cardiovascular Development, Shannon Erhardt

Theses/Dissertations from 2021

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4D EX VIVO CRISPR/CAS9 WHOLE-GENOME SCREEN TO IDENTIFY GENES REGULATING LUNG CANCER METASTASIS, Alexandria Plumer

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ADVANCEMENT OF A 3D COMPUTATIONAL PHANTOM AND ITS AGE SCALING METHODOLOGIES FOR RETROSPECTIVE DOSE RECONSTRUCTION STUDIES, Aashish Gupta

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A FULLY-AUTOMATED, DEEP LEARNING-BASED FRAMEWORK FOR CT-BASED LOCALIZATION, SEGMENTATION, VERIFICATION AND PLANNING OF METASTATIC VERTEBRAE, Tucker Netherton and Tucker James Netherton

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Agonist-Induced Conformational Changes in the NMDA Receptor, Ryan Durham and Ryan Durham

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A Novel Role for DYRK1A in Kidney Development, Alexandria Blackburn

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Assessing Genetic Counselors' Clinical Approach and Practices Regarding Pathogenic/Likely Pathogenic Variant Downgrades, Grant Bonesteele

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Assessing the Outcomes of Blocking CCL2-CCR2 Signaling Axis on Breast Cancer Brain Metastasis, Yutao Qi

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ATRX INACTIVATION AND IDH1-R132H DRIVE PREFERENTIAL SENSITIVITY TO PROTON VS. X-RAY RADIOTHERAPY IN GLIOMA STEM CELLS, Ángel Adrián Garcés

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AUTOMATION OF RADIATION TREATMENT PLANNING FOR CERVICAL CANCER, Dong Joo Rhee

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BIASES AND BLIND-SPOTS IN GENOME-WIDE CRISPR-CAS9 KNOCKOUT SCREENS, Merve Dede

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Breast Cancer Risk for Female Relatives of Male Breast Cancer Patients with Negative BRCA1/2 Testing, Emily Martin

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Characterization of a novel oncogenic miRNA inhibitor in cancer therapy, Iman Sahnoune

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Characterizing the Role of UCHL5 in Metastatic Melanoma, Seenya Vincent

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Combination of Oncolytic Adenoviruses, T-cell Activation, and Blockade of IDO Metabolic Circuitry for the Treatment of Glioma, Teresa Nguyen

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Computational Approaches to Delineate Transcriptional and Functional Heterogeneity in Pancreatic Cancer, Sanjana Srinivasan

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Conserved Non-Pocket Interactions Drive the Diversity of Peptide Presentation by MHC Class I Molecules, Kyle Jackson

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Cortical Dynamics of Language, Kiefer Forseth

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Cross-Seeding Potential of Misfolded Amyloid-beta Strains on Tau Protein: Examining the Puzzle Pieces of Alzheimer's Disease, Sara Kelley

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DECIPHERING THE ROLE OF HSP110 CHAPERONES IN DISEASES OF PROTEIN MISFOLDING, Unekwu M. Yakubu

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Dermatological concerns for women and girls with Turner syndrome, Meaghan Mones, Siddharth K. Prakash, Kate Mowrey, Michelle Rivera-Davila, Melissa B. Aldrich, and David F. Rodriguez-Buritica

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Development of Quantitative Molecular Photoacoustic Imaging for Noninvasive Cancer Diagnostics, Cayla Zandbergen

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Development of Quantitative Ultrasound-Mediated Molecular Imaging of the Tumor Microenvironment, Trevor Mitcham

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Disability Awareness Education and Implications for Genetic Counselor Training, Lauren Douglas, Chelsea Wagner, Jennifer Czerwinski, Myla Ashfaq, Rebecca Lunstroth, and Rose Vukoic

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DISCOVERY OF NOVEL UBIQUITIN- AND METHYLATION-DEPENDENT INTERACTIONS USING PROTEIN DOMAIN MICROARRAYS, Jianji Chen

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DISSECTING THE MECHANISMS OF VENETOCLAX RESISTANCE IN MYELODYSPLASTIC SYNDROMES, Shuaitong Chen

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Dissecting Tumor Heterogeneity in Lung Cancer, Aparna Padhye

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EFFECT OF LACTOFERRIN TO INCREASE DRUG PERMEABILITY OF PRIMARY PULMONARY MYCOBACTERIAL GRANULOMAS, Thao Nguyen and Thao KT Nguyen

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Endogenous Mechanisms Regulating Myeloid Cell Mediated Inflammation During Acute Lung Injuries, Nathaniel Berg

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Engineering B cells for use in immunotherapy and cancer, Emily Ensley