Open-access, full-text copies of The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences dissertations from 2009 onwards. Topics include all aspects of the biomedical sciences.

Authors who expect to publish do have the option to withhold full text for a limited period of time. When that has been done, the reader will see a release date posted with the abstract.

Older GSBS dissertations (from approximately 1979-1999) are available, in print format only, at McGovern Historical Center. They can be found via OneSearch. Search by subject heading: "Dissertations, Academic--University of Texas Health Science Center at Houston. Graduate School of Biomedical Sciences" for the full list, click DigitalCommons@TMC in the white banner above the search box, or use the main search box to search for known individual dissertations.

Some older GSBS dissertations are also available online via ProQuest, but full-text access is restricted to TMC academic institutions affiliated with The TMC Library.

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Theses/Dissertations from 2023

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Acute manipulation of eRNA level for dissecting its roles in transcriptional regulation, Lanxin Bei

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Adipocytes and Innate Immunity in Systemic Sclerosis, Nancy Wareing

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AI-ENABLED ONLINE PLAN ADAPTATION FOR MR-GUIDED STEREOTACTIC ABLATIVE RADIOTHERAPY (SABR) OF HEAD AND NECK CANCER, Yao Zhao

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A larval zebrafish (Danio rerio) model of adherent-invasive Escherichia coli infections, Erika Flores and Erika Flores

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Automating the Radiation Therapy Treatment Planning Process for Pediatric Patients with Medulloblastoma, Soleil Hernandez

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Auto-segmentation in Pancreatic and Liver Radiation Therapy, Cenji Yu

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BAYESIAN SEMI-MECHANISTIC DOSE-FINDING DESIGNS FOR PHASE I ONCOLOGY TRIALS, Chao Yang

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Conformational rearrangements in the sensory RcsF/OMP complex mediate signal transduction across the bacterial cell envelope, Sarah Rosemarie Lach PhD

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DeepHTLV: a Deep Learning Framework for Detecting Human T-Lymphotrophic Virus 1 Integration Sites, Johnathan Jia and Johnathan Jia

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DEVELOPMENT OF NOVEL METHODS TO STUDY HOST-MICROBE INTERACTIONS IN THE LARVAL ZEBRAFISH GASTROINTESTINAL TRACT, Anh K. Trinh Nguyen

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Elucidating mechanisms involved in host microbial-tumor interactions, Vidhi Chandra

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ELUCIDATING THE DIRECT ROLE OF M6A IN THE HUMAN TRANSCRIPTOME, Lana Al Hasani

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Extending the Lifetime of Optically Stimulated Dosimeters for Use in Output Checks at IROC- Houston, Hayden Scott

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FUNCTIONAL ANALYSIS OF DAXX IN TUMORIGENESIS OF PANCREATIC NEUROENDOCRINE TUMORS AND EMBRYONIC DEVELOPMENT, Chang Sun

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Functions of the tRNA splicing endonuclease and other adventures in RNA processing, Jennifer Hurtig and Ambro van Hoof

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Gene Expression–Based Algorithms for the Identification of Drug Combinations in Personalized Medicine, Lon Fong

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Genetic analysis of crossover defective mouse spermatocytes reveals discrete crossover precursor intermediates, Tolkappiyan Prem Kumar

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Genetic Regulation of Müllerian Duct Regression, Malcolm Moses

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HYPOXIA ACTIVATED PRODRUG AND ANTI-ANGIOGENIC THERAPY COOPERATE TO TREAT PANCREATIC CANCER BUT ELICIT IMMUNE SUPPRESSIVE G-MDSC INFILTRATION, Arthur Liu

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Identifying functional enhancers for fibrotic gene regulation in liver fibrosis, Parnaz Merikhian

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Impact of Personal, Familial, and Socioeconomic Factors on the Return of Remotely Collected Samples for Genetic Testing, Jordan Zeiger

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Impact of Recent Abortion Legislation on Patient Trust in Healthcare Providers, Jasmine Tyson MS

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Improving Dose-Response Correlations for Locally Advanced NSCLC Patients Treated with IMRT or PSPT, Yulun He

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Interrogations of the Tumor Microenvironment Using Magnetic Resonance Imaging, Tianzhe Li

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Investigating the distinct role of PD-L2 in modulating human T cells responses, Anupallavi Srinivasamani

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Investigating the Role of IL-10 Producing NKT cells in Prevention of Graft Versus Host Disease, Drew Boagni

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Investigating the roles of lung epithelial STAT3 in therapeutically inducible resistance to acute bacterial pneumonia., Vikram V. Kulkarni and VIKRAM V. KULKARNI

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Investigation of Teratogenic Concerns in the COVID-19 Era, Emily Daykin

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ISOLATION OF THERAPEUTIC ANTIBODIES AGAINST MICROSEMINOPROTIEN TO POTENTIALLY OVERCOME RESISTANCE TO ANTI-ANGIOGENIC THERAPY, Mason Ruiz

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KIR-BASED INHIBITORY CARS OVERCOME CAR-NK CELL TROGOCYTOSIS-MEDIATED FRATRICIDE AND TUMOR ESCAPE, YE NMN LI

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Landscape of ecDNA-borne non-coding RNAs in glioblastoma, Dexin Yang

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Low molecular weight cyclin E deregulates DNA replication and damage repair to promote genomic instability in breast cancer, Mi Li

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Lymphatic dysfunction and associated systemic inflammation in lymphedema, assessed by NIRF-LI imaging and plasma cytokine/chemokine analysis, Anna Vang

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Molecular mechanisms behind SARS-CoV-2 induced host genome restructuring, Erin Simpson

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Multiparametric Magnetic Resonance Imaging Artificial Intelligence Pipeline for Oropharyngeal Cancer Radiotherapy Treatment Guidance, Kareem Wahid

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p120-catenin subfamily members have distinct as well as shared effects on dendrite morphology during neuron development in vitro, Maxsam Donta

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P53 DIMERS ELICIT UNIQUE TUMOR SUPPRESSIVE ACTIVITIES THROUGH AN ALTERED METABOLIC PROGRAM, Jovanka Gencel-Augusto

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Perceived Utility of Genetic Carrier Screening in a Diverse Patient Population, Jack A. Colleran

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Potentiation of the Immune Checkpoint Blockade Response by Metabolic Modulation is Predictable using Molecular Imaging, Renee L. Chin

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PRECLINICAL EVALUATION OF IMMUNOMODULATORY EFFECTS OF AURORA KINASE INHIBITION IN HUMAN PAPILLOMAVIRUS POSITIVE CANCERS, Pragya Sinha

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Pregnant Black/African Americans' Experiences in Prenatal Genetic Counseling, Latonya Alexander

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Prenatal Screening Decision-making Facilitated Through an Online Patient Education Module, Erin Atkinson

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Protein L Functionalized Microparticles for Early Detection of Surface Markers in Heterogeneous Colorectal Lesions, Saleh Ramezani

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RECONSTRUCTING MUTATIONAL LINEAGES IN BREAST CANCER BY MULTI-PATIENT-TARGETED SINGLE CELL DNA SEQUENCING, Jake Leighton

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Regulation and Function of ZEB1 Acetylation in Lung Adenocarcinoma Progression and Metastasis, Mabel Perez-Oquendo

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Regulation of de novo and Maintenance DNA Methylation by DNMT3A and DNMT3B, Yang Zeng

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Risk and Risk Factors for Colorectal Subsequent Malignancies in Survivors of Childhood Cancer: A Report from The Childhood Cancer Survivor Study, Constance A. Owens

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Role of IL-17/IL-17RA signaling in the pancreatic tumor microenvironment, Susana Castro Pando and Susana Castro Pando

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Role of Phosphorylated DICER1 in Tumor Progression, Raisa Reyes-Castro

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S-Acylation is a Key Regulator of Orai1/STIM1-Mediated Store-Operated Calcium Entry in T Cells, Savannah J. West Diaz

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Spanish-speaking limited English-proficient patient satisfaction and comfort when comparing Spanish-speaking provider to an interpreter, Cindy Hernandez

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Statistical Approaches to Estimate Bidirectional and Time-Varying Causal Effects Using Mendelian Randomization, Jinhao Zou

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Statistical Modeling Approaches for the Inference of Cancer Mechanisms, Licai Huang

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TARGETING METABOLIC ALTERATIONS ASSOCIATED WITH SMOOTH MUSCLE α-ACTIN PATHOGENIC VARIANT ATTENUATES MOYAMOYA-LIKE CEREBROVASCULAR DISEASE, Anita Kaw

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The CX3CL1-CX3CR1 chemokine axis contributes to tumor immune evasion and its blockade enhances responses to anti-PD-1 immunotherapy, Apoorvi Chaudhri

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The Development of Artificial Intelligence-Based Tools for Expert Peer Review of Radiotherapy Treatment Plans, Mary Gronberg

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The Diagnostic Odyssey of Hypermobile EDS Patients: Diagnosis, Clinical Expectations, and Psychosocial Concerns, Madeline Alpar

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The Impact of Treatment with Palynziq® on Quality of Life for Individuals with PKU, Teresa Heller

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The Need for Racial and Ethnic Health Disparity Curriculum in Genetic Counseling Programs, Yusra Aziz

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Therapeutic potential of PRMT5 and MAT2A as synthetic lethal targets in MTAP-deficient GBM tumors, Yasaman Barekatain

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The Safe and Effective Clinical Deployment of Artificial Intelligence Tools, Kelly Nealon

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Toward nonparametric propensity score estimation with guaranteed covariate balance, Yan Li

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Treatment Planning Automation for Rectal Cancer Radiotherapy, Kai Huang

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Uncertainty in the physical basis of estimates of relative biological effectiveness in carbon radiotherapy, Shannon Hartzell and Shannon Hartzell Ph.D.

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Uncovering Molecular Targets to Overcome Immunosuppression in Non-Small Cell Lung Cancer with Acquired TKI Resistance, Sonia A. Patel

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Uncovering Novel Mechanism of Immune Modulation of invariant Natural Killer T Cells by Liposomal α-Galactosylceramide, Alexandra S. Flegle

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UNIQUE TRANSCRIPTIONAL PROFILES UNDERLIE OSTEOSARCOMAGENESIS DRIVEN BY DIFFERENT p53 MUTANTS, Dhruv Chachad

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UNVEILING IMMUNE CHECKPOINT THERAPY RESISTANCE MECHANISMS IN THE TUMOR MICROENVIRONMENT USING HIGH-DIMENSIONAL ANALYSES, Swetha Anandhan

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Y CHROMOSOME GENE KDM5D EPIGENETICALLY DRIVES SEX DIFFERENCES IN COLORECTAL CANCER, Jiexi Li

Theses/Dissertations from 2022

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Absolute Quantification of Tc-99m Activity Distributions Using a Planar Molecular Breast Imaging Commercial System, Benjamin P. Lopez

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A MICROFLUIDICS-BASED APPROACH FOR ISOLATION OF ANTIGEN-SPECIFIC CD8+ T CELLS, Meredith Frank

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A molecular and in vivo investigation of advanced prostate cancer: Deconstructing AMPK activity and developing an improved mouse model, Sandi Wilkenfeld

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Analysis of Huntington Disease Caregiver Quality of Life Using the Enroll-HD Population, Emilyn Banfield

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Analysis of the Distributed Representation of Operant Memory in Aplysia, Renan Murillo Costa

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An Investigation of Epigenetic Mechanisms Driving the Biology of Head and Neck Squamous Cell Carcinoma, Scot Carson Callahan

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ANKYRIN DEPENDENT MITOCHONDRIAL FUNCTION AND BIOENERGETICS IN THE HEART, Janani Subramaniam and Janani Subramaniam

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Assessing the Impact of Camp PHEver on Blood Phenylalanine Levels, Michelle Zelnick

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ATR-MEDIATED CD47 AND PD-L1 UPREGULATION RESTRICTS RADIOTHERAPY-INDUCED IMMUNE PRIMING AND ABSCOPAL RESPONSES IN COLORECTAL CANCER, Cheng-En Hsieh and Cheng-En Hsieh

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Bayesian Adaptive Clinical Trial Design, Mengyi Lu

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Bayesian Adaptive Designs for Proof-of-Concept Trials and Platform Trials, Yujie Zhao

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BHLHE40: Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy, Avery Salmon and Avery J. Salmon

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Body temperature and diet as drivers of obesity development, Jessie Morrill

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Cell-free DNA Sequencing in Multiple Myeloma, Russell Irwin

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Clinical Impact of a Highly Sensitive Next-Generation Sequencing Measurable Residual Disease Assay in Patients with Acute Lymphoblastic Leukemia, Nicholas Short

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COMPUTATIONAL APPROACHES TO UNDERSTAND CHEMORESISTANCE & TUMOR EVOLUTION USING LONGITUDINAL CLINICAL DATA AND LINEAGE TRACING, Sahil Seth

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Concomitant inhibition of FLT3 and MCL-1 in FLT3 mutated Acute Myeloid Leukemia, Paul Panis

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Decoding Copy Number Substructure and Evolution from Single Cell Genomics, Darlan Conterno Minussi

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Decoding the Tumor and Immune Microenvironment in PDAC and Breast Cancer by Single Cell Sequencing., Aislyn Schalck

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DEFINING THE COOPERATION BETWEEN MHC-I AND MHC-II NEOANTIGEN-DRIVEN T CELL RESPONSES TO DEVELOP EFFECTIVE PERSONALIZED IMMUNOTHERAPIES, Charmelle Williams

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Development and Characterization of B7-H3-Targeted Radioimmunotherapies for the Treatment of Solid Tumors, Sarah Glazer

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Development of Advanced MR-Guided Adaptive Radiation Therapy Methods for Head & Neck Cancers on the 1.5T MR-Linac, Brigid McDonald

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Development of Graphical Models and Statistical Physics Motivated Approaches to Genomic Investigations, Yashwanth Lagisetty

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DEVELOPMENT OF THE ARK ASSAY FOR QUANTITATING DNA- PROTEIN CROSSLINK ACCUMULATION AND FANCONI ANEMIA PATHWAY INVOLVEMENT IN THE REPAIR PROCESS, Naeh Klages-Mundt

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DOXORUBICIN-INDUCED CARDIOTOXICITY IS MEDIATED BY NEUTROPHILS THROUGH RELEASE OF NEUTROPHIL ELASTASE, Anchit Bhagat

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EFFICACY OF DUAL CD19-CD79b CAR IN B-CELL MALIGNANCIES, Xiaoyun Cheng

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EXPERIENCES OF RACIAL AND ETHNIC MINORITY PATIENTS WITH GENETIC COUNSELING, Emile Moura Coelho da Silva

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EXPLOITING CHEMOGENETIC AND GENETIC INTERACTIONS IN HUMAN CELLS AS AN AVENUE FOR NEW THERAPEUTIC OPPORTUNITIES, Medina Colic

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Genetic analysis of RNA exosome complex cofactors, Luisa Orlando

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Genomewide CRISPR/Cas9 Screen Identifies Network of Protein Complexes that Regulate TRIM24, Lalit Patel

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GRK3 CONNECTS ANGIOGENESIS AND NEUROENDOCRINE DIFFERENTIATION IN PROSTATE CANCER BY ACTIVATING HDAC2 THAT EPIGENETICALLY REPRESSES TSP1 AND REST, Samira Naderinezhad