Open-access, full-text copies of The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences dissertations from 2009 onwards. Topics include all aspects of the biomedical sciences.

Authors who expect to publish do have the option to withhold full text for a limited period of time. When that has been done, the reader will see a release date posted with the abstract.

Older GSBS dissertations (from approximately 1979-1999) are available, in print format only, at McGovern Historical Center. They can be found via OneSearch. Search by subject heading: "Dissertations, Academic--University of Texas Health Science Center at Houston. Graduate School of Biomedical Sciences" for the full list, click DigitalCommons@TMC in the white banner above the search box, or use the main search box to search for known individual dissertations.

Some older GSBS dissertations are also available online via ProQuest, but full-text access is restricted to TMC academic institutions affiliated with The TMC Library.

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Theses/Dissertations from 2021

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Computational Approaches to Delineate Transcriptional and Functional Heterogeneity in Pancreatic Cancer, Sanjana Srinivasan

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Conserved Non-Pocket Interactions Drive the Diversity of Peptide Presentation by MHC Class I Molecules, Kyle Jackson

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Cortical Dynamics of Language, Kiefer Forseth

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Cross-Seeding Potential of Misfolded Amyloid-beta Strains on Tau Protein: Examining the Puzzle Pieces of Alzheimer's Disease, Sara Kelley

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DECIPHERING THE ROLE OF HSP110 CHAPERONES IN DISEASES OF PROTEIN MISFOLDING, Unekwu M. Yakubu

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Dermatological concerns for women and girls with Turner syndrome, Meaghan Mones, Siddharth K. Prakash, Kate Mowrey, Michelle Rivera-Davila, Melissa B. Aldrich, and David F. Rodriguez-Buritica

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Development of Quantitative Molecular Photoacoustic Imaging for Noninvasive Cancer Diagnostics, Cayla Zandbergen

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Development of Quantitative Ultrasound-Mediated Molecular Imaging of the Tumor Microenvironment, Trevor Mitcham

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Disability Awareness Education and Implications for Genetic Counselor Training, Lauren Douglas, Chelsea Wagner, Jennifer Czerwinski, Myla Ashfaq, Rebecca Lunstroth, and Rose Vukoic

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DISCOVERY OF NOVEL UBIQUITIN- AND METHYLATION-DEPENDENT INTERACTIONS USING PROTEIN DOMAIN MICROARRAYS, Jianji Chen

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DISSECTING THE MECHANISMS OF VENETOCLAX RESISTANCE IN MYELODYSPLASTIC SYNDROMES, Shuaitong Chen

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Dissecting Tumor Heterogeneity in Lung Cancer, Aparna Padhye

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EFFECT OF LACTOFERRIN TO INCREASE DRUG PERMEABILITY OF PRIMARY PULMONARY MYCOBACTERIAL GRANULOMAS, Thao Nguyen and Thao KT Nguyen

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Endogenous Mechanisms Regulating Myeloid Cell Mediated Inflammation During Acute Lung Injuries, Nathaniel Berg

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Engineering B cells for use in immunotherapy and cancer, Emily Ensley

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Enhancing Adoptive Cell Therapy by Augmenting Fitness and Anti-tumor function of Tumor-infiltrating lymphocytes, Parin Shah

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EPITHELIAL MEMORY OF RESOLVED INFLAMMATION LIMITS TISSUE DAMAGE WHILE PROMOTING PANCREATIC TUMORIGENESIS, I-Lin Ho

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Evaluating Insurance Approval Rates of Exome Sequencing and its Effect on Minority Patients' Access to Genetic Care, Katlyn Frane

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Exploring Motivational Factors to Pursue Genetic Counseling and Testing in Adolescent and Young Adult Cancer Patients, Megan Morand

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FUNCTIONS OF DCP2 AND SKI7 IN MRNA DEGRADATION, Minseon Kim and Ambro van Hoof

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Genetic Pathway Analysis of Abnormal Facial Development in Nonsyndromic Cleft Lip and Palate, lorena maili

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Genetics in the NICU: Nurses’ Perceived Knowledge and Desired Education, Kathleen Shields

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Genetic Testing in Pregnancies with Ultrasound Anomalies: Exploration of Factors that Influence Uptake, Lukas D. Kruidenier

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Hypoxia Acts as an Environmental Cue for the Human Tissue-Resident Memory T-cell Differentiation Program, Farah Hasan

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Identification and characterization of de novo germline TP53 mutation carriers in families with Li-Fraumeni Syndrome, Carlos C. Vera Recio

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IDENTIFICATION AND TARGETING OF DOWNSTREAM AR-CAMKK2-MEDIATED MECHANISMS FOR THE TREATMENT OF ADVANCED PROSTATE CANCER, Chenchu Lin

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Imaging Based Prediction of Pathology in Adult Diffuse Glioma with Applications to Therapy and Prognosis, Evan Gates

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Impact of Intratumor Heterogeneity and the Tumor Microenvironment in Shaping Tumor Evolution and Response to Therapy, Akash Mitra

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IMPROVING TREATMENT OF LOCAL LIVER ABLATION THERAPY WITH DEEP LEARNING AND BIOMECHANICAL MODELING, Brian Anderson, Kristy Brock, Laurence Court, Carlos Eduardo Cardenas, Erik Cressman, and Ankit Patel

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Increased oxidative phosphorylation in an iPSC- derived model of Rothmund-Thomson syndrome associated osteosarcomagenesis, Brittany Jewell

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INTRANASAL HPV PEPTIDE VACCINE FORMULATION INDUCES POTENT CYTOTOXIC CD8 T CELL IMMUNITY FOR THE TREATMENT OF GENITAL HPV TUMORS, Gloria Sierra

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Investigating Barriers Experienced by Underrepresented Minorities in Becoming a Competitive Genetic Counseling Applicant, Katie Huang

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INVESTIGATING DIFFUSION TENSOR IMAGING CORRELATES OF COGNITIVE IMPAIRMENT IN IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS AND ALZHEIMER'S DISEASE, Omar Hasan and Omar Hasan

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Investigating Mechanisms in Nociceptors Driving Ongoing Activity and Ongoing Pain, Elia Lopez

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INVESTIGATING THERAPEUTIC STRATEGIES TO TARGET METABOLIC VULNERABILITIES OF NSCLC TUMORS WITH MUTANT KEAP1 GENE, Pranavi Koppula

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Investigating the role of Abro1 in DNA damage-induced immune response, Ahmed Emam

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Investigation of trophon® 2 for High Level Disinfection of Rigid Endorectal MRI Coils, Rebecca DiTusa

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Isolated, Absent Cavum Septum Pellucidum: A Single Center’s Outcomes and Review of the Literature, Renee Bardini

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LGR5 Regulation of STAT3 Signaling and Drug Resistance in Colorectal Cancer, Tressie Posey and Tressie Alexandra Posey

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MANIPULATING ENHANCER RNA ACTIVITY TO STUDY THEIR ROLES IN GENE REGULATION AND CANCER, Zian Liao

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MicroRNAs as a Therapeutic Target to Regulate Microglial Activation in Post­ Stroke Isolation in Aged Male Mice, Anik Banerjee

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Mitochondrial Unfolded Protein Response Regulator ATF5 in Mitochondrial Targeted Therapies in AML, Ran Zhao

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Mixture Model Approaches to Integrative Analysis of Multi-Omics Data and Spatially Correlated Genomic Data, Ziqiao Wang

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Modulating Immunometabolism to Improve the Activity of CAR-NK Cells Targeting CD70 in Renal Cell Carcinoma, Hind Rafei

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MODULATION OF THE RECEPTOR GATING MECHANISM AND ALLOSTERIC COMMUNICATION IN IONOTROPIC GLUTAMATE RECEPTORS, Nabina Paudyal and Nabina Paudyal

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MOLECULAR DRIVERS OF BLADDER CANCER MOTILITY, Bryan Wehrenberg

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Mutant KRAS Alters Extracellular Vesicle MicroRNA Sorting in Pancreatic Cystic Neoplasms, Rachel L. Dittmar

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NPSD4: A NEW PLAYER IN SUMO-DEPENDENT DNA REPAIR, Erin Atkinson

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Quantitative Magnetic Resonance Imaging for the Early Prediction of Treatment Response in Triple Negative Breast Cancer, Benjamin C. Musall

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Rare variant association studies in Crohn’s Disease and Colorectal Cancer: methods and applications, Jiun-Sheng Chen

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REGULATION OF LUNG MESENCHYMAL CELLS BY EPITHELIAL WNT LIGANDS, Odemaris Narvaez del Pilar

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ROLE OF METHYLTRANSFERASE LIKE-3 (METTL3) IN PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) PROGRESSION, Bhargavi Brahmendra Barathi

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Spectrum and Incidence of Primary and Therapy-Related Hematologic Malignancies in Individuals with BRCA1 and BRCA2 Pathogenic Variants, Rosemary Rogers and Rosemary Rogers

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STAT3 INHIBITS TYPE I INTERFERON SIGNALING IN TYPE I CONVENTIONAL DENDRITIC CELLS, Taylor Chrisikos

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SYNTHETIC ESSENTIALITY OF TDO2 IN APC-MUTATED COLORECTAL CANCER, Rumi Lee

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Targeting Plasma Membrane Phosphatidylserine Content to Inhibit Oncogenic KRAS Function, Walaa E. Kattan

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The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin, Amelie Simone Cordelia Albrecht

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The Functional Contribution Of Adaptive Immunity In The Biology Of Pancreatic Cancer And Therapeutic Targeting Of Oncogenic Kras, Krishnan Mahadevan

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The impact of synchrony on neuronal coding and behavior, Natasha Kharas

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The Importance of DNA Repair Capacity to (and a Model to Predict) Cell Radiosensitivity to Ions, David B. Flint and David B. Flint

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The microsatellite instability high endometrial tumor microenvironment and identifying predictive biomarkers of response to pembrolizumab, Jeffrey How

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The role of IFITM3 in the immune response of BRCA-deficient high grade serous ovarian carcinoma, Han Cun

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The Role of PAG1 in the Activated B-Cell Subtype of Diffuse Large B-Cell Lymphoma, Jared Henderson

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The Src- and Abl- Dependent Regulation of Net1A in Breast Cancer, Ashabari Sprenger

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TRIM24 promotes mammary tumor development by upregulating metabolic reducing power, Shucheng Miao

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Understanding the Pathogenesis of Renal Medullary Carcinoma, Melinda Soeung

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UNDERSTANDING THE ROLE OF ARGLU1 IN INTERFERON SIGNALING ACTIVATION IN BREAST CANCER, Phuoc Nguyen

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Unraveling Host-Gut Microbiota Dialogue and Its Impact on Response to Immune Checkpoint Blockade, Alexandria Cogdill

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Unveiling global roles of G-quadruplexes and G4-22 in human genetics, Ruth Barros De Paula

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Vascular Disease Pathogenesis in Smooth Muscle Dysfunction Syndrome and Majewski Osteodysplastic Primordial Dwarfism Type II, Jamie Wright

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Virulence and biofilm formation in Candida albicans are inhibited by short peptide subunits of EntV, Shane Cristy

Theses/Dissertations from 2020

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A CONTEXT-FORWARD IN VIVO FUNCTIONAL GENOMICS PLATFORM FOR TARGET DISCOVERY AND ESTABLISHING VULNERABILITY CONTEXT IN PANCREATIC CANCER, Johnathon Rose and Johnathon Lynn Rose

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ACTIVE MAGNETIC RADIATION SHIELDING FOR LONG-DURATION HUMAN SPACEFLIGHT, Kristine Ferrone

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Aging Lowers PEX5 Levels in Cortical Neurons in Male and Female Mouse Brains, Ndidi-Ese Uzor

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ALTERNATIVE CARBON UTILIZATION AS A VIRULENCE DETERMINANT FOR CANDIDA ALBICANS, Robert Williams

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ALTERNATIVE POLYADENYLATION MODULATES EXPRESSION OF PRO-FIBROTIC PROTEINS AND CONTRIBUTES TO LUNG FIBROSIS, Junsuk Ko

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An Exploration of Neuroanatomical Signatures of Pediatric Bipolar Disorder Using Structural Neuroimaging, Jonika Tannous

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A Pharmacological Strategy Against African Sleeping Sickness, Wahaj Zuberi

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Artificial intron technology to generate conditional knock-out mice, Amber N. Thomas-Gordon

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A SCREEN FOR PEPTIDES TARGETING CHEMORESISTANT METASTATIC TRIPLE-NEGATIVE BREAST CANCER, Shraddha Subramanian

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Assessing Patient Attitudes toward Genetic Testing for Hereditary Hematologic Malignancy, Addison Johnson

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ASTROCYTES RESCUE NEURONAL HEALTH AFTER CISPLATIN TREATMENT THROUGH MITOCHONDRIAL TRANSFER., Krystal English and Krystal English

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BAYESIAN ADAPTIVE DESIGNS AND VERSATILE SOFTWARE PLATFORM FOR EARLY PHASE CLINICAL TRIALS, Yanhong Zhou

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BRINGING TIL THERAPY BEYOND MELANOMA: ADVANCING THE TREATMENT OF ADVANCED PANCREATIC AND OVARIAN CANCERS, Donald Sakellariou-Thompson

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BST2 ISOFORMS: DISTRIBUTION AND POTENTIAL USE IN CANCER THERAPEUTICS, Ahmed Muhsin

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Calcium Dyshomeostasis in Neurodegeneration, Nicholas Emanuel Karagas

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CELLULAR AND CIRCUIT PROPERTIES OF SLOW OSCILLATIONS IN THE THALAMIC RETICULAR NUCLEUS, John O'Malley

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Characterization of Treatment Planning System Photon Beam Modeling Errors in IROC Houston Phantom Irradiations, Mallory Glenn

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COMBINED INHIBITION OF DDR1 AND CDK4/6 INDUCES SYNERGISTIC EFFECTS IN ER-POSITIVE, HER2-NEGATIVE BREAST CANCER WITH PIK3CA/AKT1 MUTATIONS, maryam shariati and maryam shariati

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DECODING THE EVOLUTIONARY RESPONSE TO PROSTATE CANCER THERAPY USING PLASMA GENOME SEQUENCING, Naveen Ramesh

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DEVELOPMENT OF A CT METAL ARTIFACT MANAGEMENT ALGORITHM FOR PROTON THERAPY PLANNING (AMPP) FOR HEAD AND NECK CANCER PATIENTS, Daniela Branco

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DEVELOPMENT OF COMPUTATIONAL TOOLS TO TARGET MICRORNA, Luo Song

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Development of fully balanced SSFP and computer vision applications for MRI-assisted radiosurgery (MARS), Jeremiah Sanders

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Directed Evolution of Macrocyclic Peptides for Inhibition of Autophagy, Joshua Gray

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Disruption of DNA Polymerase Zeta Promotes an Innate Immune Response, Sara Martin

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Effect of sympathetic nervous system mediators on the tumor microenvironment via small extracellular vesicles in ovarian cancer, Sujanitha Umamaheswaran and Sujanitha Umamaheswaran

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EFFECTS OF PENFLURIDOL ON INTEGRIN-FAK SIGNALING AND TUMOR CELL KILLING IN COMBINATION WITH ONCOLYTIC HSV IN GLIOBLASTOMA, Mitra Nair

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Elevated cochlear adenosine causes hearing loss via ADORA2B signaling, Jeanne Manalo

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ELUCIDATING THE ROLES OF IL-15 IN THE TUMOR MICROENVIRONMENT, Rosa Maria Santana Carrero

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EXOSOMAL COMMUNICATION BY METASTATIC OSTEOSARCOMA CELLS MODULATES ALVEOLAR MACROPHAGES TO AN M2 TUMOR-PROMOTING PHENOTYPE AND INHIBITS TUMORICIDAL FUNCTIONS, Kerri Wolf