Open-access, full-text copies of UT GSBS dissertations from 2009 onwards. Topics include all aspects of the biomedical sciences.

Authors who expect to publish do have the option to withhold full text for a limited period of time. When that has been done, the reader will see a release date posted with the abstract.

Older UT GSBS dissertations (from approximately 1979-1999) are available, in print format only, at McGovern Historical Center. They can be found via OneSearch. Search by subject heading: "Dissertations, Academic--University of Texas Health Science Center at Houston. Graduate School of Biomedical Sciences" for the full list, click DigitalCommons@TMC in the white banner above the search box, or use the main search box to search for known individual dissertations.

Some older GSBS dissertations are also available online via ProQuest, but full-text access is restricted to TMC academic institutions affiliated with The TMC Library.

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Theses/Dissertations from 2018

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IDENTIFYING MOLECULAR TARGETS AND VALIDATING NOVEL THERAPIES FOR OVARIAN CANCER, Alejandro Villar-Prados

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Identifying Subunit Organization and Function of the Nuclear RNA Exosome Machinery, Jillian Losh

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IL-1α BLOCKADE REDUCES IMMUNE SUPPRESSION IN THE EARLY TUMOR MICRO-ENVIRONMENT, Brenda Melendez

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Improved Target Coverage of Spinal Metastases Through the Use of Flattening Filter Free Beams, Laura Bennett

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Improving dbNSFP, Mingyao Lu

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INSIGHTS INTO THE REACTIVATION, REGULATION AND ESSENTIALITY OF OXIDATIVE PROTEIN FOLDING PATHWAYS IN ACTINOBACTERIA, Belkys Sanchez

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INTEGRATIVE BIOINFORMATICS APPROACHES TO ELUCIDATING PROSTATE CANCER CELL HETEROGENEITY, PLASTICITY, AND TREATMENT RESPONSE, Hsueh-Ping Chao

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Intratumoral STING Activation Sensitizes Poorly Immunogenic Cancers to Checkpoint Blockade Immunotherapy, Casey Ager

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INVESTIGATING INVASION IN DUCTAL CARCINOMA IN SITU WITH TOPOGRAPHICAL SINGLE CELL GENOME SEQUENCING, Anna Casasent and Anna Casasent

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INVESTIGATING THE IMPACT OF INTRAGENIC DNA METHYLATION ON GENE EXPRESSION, AND THE CLINICAL IMPLICATIONS ON TUMOR CELLS AND ASSOCIATED STROMA, Michael McGuire

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INVESTIGATING THE ROLES OF TAP63 AND TAP73 IN CUTANEOUS SQUAMOUS CELL CARCINOMA AND LUNG ADENOCARCINOMA, Andrew J. Davis

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INVESTIGATING THE SINGLE CELL HETEROGENEITY AND PHYSIOLOGICAL IMPACT OF MISTRANSLATION, Christopher Evans

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Investigation of Novel Virulence Mechanisms in Candida albicans, Elisa Marie Tafoya Vesely

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INVOLVEMENT OF GDAP1 IN THE REGULATION OF MTORC1 ACTIVITY IN A DROSOPHILA MLIV MODEL, Kristen Clemons

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ISCHEMIC STROKE DAMAGE IS REDUCED BY INHIBITION OF IL-6 SIGNALING WITH TOCILIZUMAB, Jacob Hudobenko

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Mechanism of Incorporation and Repair of Uracil at Highly Transcribed Genes In Saccharomyces Cerevisiae, Norah Auma Owiti

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MECHANISMS AND TARGETING OF NEURODEVELOPMENTAL REGULATOR REST IN MEDULLOBLASTOMA DISSEMINATION, Keri Callegari

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MICRORNA FUNCTIONS IN UV-INDUCED CUTANEOUS SQUAMOUS CELL CARCINOMA, Tran Nguyen

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miR-484 Functions as an Onco-miR in Triple Negative Breast Cancer, Nashwa Kabil

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Nanoscale Organization of the Small GTPase Rac1, Kelsey Maxwell

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Omics Approaches to Uncover Germline and Somatic Variation Underlying Inherited Sarcomagenesis, Justin Wong

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Outcomes of Genetic Testing in a Genitourinary Genetics Clinic, Annelise Pace

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Patient Attitudes Toward Genetic Testing for Inherited Predispositions to Hematologic Malignancies, Taylor Beecroft

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PHOSPHORYLATION IMPAIRS DICER1 FUNCTION TO ACCELERATE AGING AND TUMORIGENESIS IN VIVO, Neeraj Aryal

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POPULATION CODES AND THEIR CORRELATES IN DECISION MAKING, Neda Shahidi

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PREDICTION OF 1P/19Q CODELETION STATUS IN DIFFUSE GLIOMA PATIENTS USING PREOPERATIVE MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING, Donnie Kim

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Psychiatric Impact of Tuberous Sclerosis Complex and Utilization of Mental Health Treatment, Kate Mowrey

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ROLE OF P300 ZZ DOMAIN IN CHROMATIN ASSOCIATION AND HISTONE ACETYLATION, Yongming Xue

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SIMVASTATIN DOES NOT SENSITIZE IBC3 HER2+ INFLAMMATORY BREAST CANCER BRAIN METASTASES TO WHOLE BRAIN IRRADIATION IN AN IMMUNOCOMPROMISED MOUSE MODEL, Swaminathan Kumar

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Somatostatin Receptor 2 Regulation by C-terminal Motifs and PDZ Domain Proteins, Courtney Olsen

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SPHINGOSINE KINASE 1 REGULATES FASCIN EXPRESSION TO PROMOTE METASTASIS IN TRIPLE NEGATIVE BREAST CANCER, Sunil Acharya

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STRUCTURE BASED DRUG DESIGN OF HIGH AFFINITY KRAS INHIBITORS, Michael McCarthy

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Targeting PH domain proteins for cancer therapy, Zhi Tan

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The Cross-Talk Between Neurons and Microglia Through Interleukin-4 After Ischemic Injury, Shun-Ming Ting

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The Epithelial To Mesenchymal Transition In Breast Cancer Induces Alterations In Metabolism, Esmeralda Ramirez-Peña

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THE PROTECTIVE EFFECTS OF MEMANTINE ON THE MORPHOLOGY AND ACTIVITY OF IRRADIATED DENDRITIC SPINES, Thanh Lam

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The Regulation of DNA Methylation in Mammalian Development and Cancer, Nicolas Veland

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The Role of Merlin and Apicobasal Polarity in Endometrial Development and Homeostasis, Erin Lopez

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The Role of Perivascular FIbrosis in Post-Stroke Glymphatic Impairment and Cerebral Amyloid Angiopathy, Matthew D. Howe

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The Role of Tumor Suppressor DEAR1 in the Acquisition of Mammary Stem/Progenitor Cell Properties, Uyen Le

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TRICHURIS MURIS WHEY ACIDIC PROTEIN INDUCES TYPE 2 PROTECTIVE IMMUNITY AGAINST WHIPWORM, Neima Briggs

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TRIM24 as an Oncogene in the Mammary Gland, Aundrietta Duncan

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Trim24 in Normal & Malignant Hematopoiesis, Justin Shaw

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TUMOR IMMUNOTHERAPY: MECHANISMS OF ACQUIRED RESISTANCE AND CHARACTERIZATION OF IMMUNE RELATED TOXICITIES, Ashvin Jaiswal

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UBE4B LEVELS DETERMINE THE EFFICACY OF EGFR AND STAT5 INHIBITORS IN TREATMENT RESISTANT NEUROBLASTOMA, David James Savage

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VASCULAR INJURY IN Col3a1+/- MICE MODEL OF VASCULAR EHLER-DANLOS SYNDROME, Ping ZHOU MS

Theses/Dissertations from 2017

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A LICENSE TO KILL: UNDERSTANDING NATURAL KILLER CELL LICENSING TO FIGHT CANCER, Jolie Schafer

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ANALYSIS OF THE BIOCHEMICAL AND CELLULAR ACTIVITIES OF SUBSTRATE BINDING BY THE MOLECULAR CHAPERONE HSP110/SSE1, Veronica M. Garcia

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ANDROGEN RECEPTOR AND PROSTATE CANCER CELL HETEROGENEITY, Qu Deng

A PRECLINICAL STUDY OF RADIATION-INDUCED LUNG TOXICITY WHEN IRRADIATING IN A STRONG MAGNETIC FIELD, Ashley E. Rubinstein

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A tail-based test for differential expression analysis and pathway analysis in RNA-sequencing data, Jiong Chen

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Attitudes of Clinicians Towards Cardiac Surgery and Trisomy 18, Meagan Kaulfus

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Attitudes Toward and Uptake of Prenatal Genetic Screening and Testing in Twin Pregnancies, Kathryn M. Reese

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Barriers to Expansion of Supervision Networks at Genetic Counseling Training Programs, Jordan E. Berg

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CD47+ Exosomes Facilitate Effective Targeting of Oncogenic Kras in Pancreatic Cancer, Sushrut Kamerkar

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CHARACTERIZATION AND REVERSAL OF DOXORUBICIN-MEDIATED CHANGES IN SENSORY NEURONS, Brittany L. Coughlin

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CHARACTERIZATION OF NOTCH1 AND PI3K-PTEN-AKT/mTOR PATHWAY INTERACTION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA, Kyriante' Henry

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CHARACTERIZATION OF THE ROLE OF THE pKM101-ENCODED T4SS OUTER MEMBRANE CORE COMPLEX IN SUBSTRATE TRANSFER, PILUS BIOGENESIS, AND RECIPIENT CELL CONTACT, Jay E. Gordon

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CHARACTERIZATION OF THE UBIQUITIN LIGASE, UBE4B, IN ENDOCYTIC TRAFFICKING, Natalie Sirisaengtaksin and Natalie Sirisaengtaksin

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Characterizing the source of neutrophil elastase and proteinase 3 cross-presentation in B-cell acute lymphoblastic leukemia, Selena Carmona

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CIRCULATING AUTOANTIBODIES IN HUMAN TRAUMATIC SPINAL CORD INJURY SUBJECTS AND THEIR RELATIONSHIP TO THE DEVELOPMENT OF NEUROPATHIC PAIN, Georgene Hergenroeder

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CLINICAL AND THERAPEUTIC SIGNIFICANCE OF OBESITY IN MELANOMA, Jennifer L. McQuade

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CLINICAL APPLICABILITY OF PROPOSED ALGORITHM FOR IDENTIFYING INDIVIDUALS AT RISK FOR HEREDITARY HEMATOLOGIC MALIGNANCIES, Maggie Clifford

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Computational Identification of Noncoding Driver Mutations Based on Impact on RNA Processing, Kevin Zhu

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Computer-Aided Detection of Pathologically Enlarged Lymph Nodes On Non-Contrast CT In Cervical Cancer Patients For Low-Resource Settings, Brian M. Anderson, Laurence E. Court, Ann Klopp, Stephen F. Kry, Jennifer Johnson, Erik Cressman, Arvind Rao, and Jinzhong Yang

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CONTRASTING EFFECTS OF AN MDM2 FUNCTIONAL POLYMORPHISM ON TUMOR PHENOTYPES, Guadalupe J. Ortiz IV

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Cyclin B1 mediates the effect of UCHL1 in promoting cell cycle progression in uterine papillary serous carcinoma, Suet Ying Kwan

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CYTOPLASMIC CYCLIN E MEDIATES RESISTANCE TO AROMATASE INHIBITORS IN BREAST CANCER, Iman Doostan

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Detecting and Evaluating Therapy Induced Changes in Radiomics Features Measured from Non-Small Cell Lung Cancer to Predict Patient Outcomes, Xenia J. Fave

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DEVELOPING NOVEL APPROACHES TO IMPROVE RESPONSE TO T CELL BASED CANCER IMMUNOTHERAPY, Rina M. Mbofung

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DYNAMIC ASSESSMENT OF NK CELL INTERACTIONS WITH PEDIATRIC TUMOR CELLS TO PREDICT RESPONSE TO IMMUNOTHERAPY, Arianexys Aquino Lopez

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EFFECT OF ENTINOSTAT ON NK CELL-MEDIATED CYTOTOXICITY AGAINST OS CELLS AND OS LUNG METASTSIS, Simin Kiany

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ENDOCYTIC TRAFFICKING OF THE AMYLOID PRECURSOR PROTEIN IN RAT CORTICAL NEURONS, sahily reyes

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Evaluating the impact of post-translational modifications by the secreted zinc metalloprotease, GelE, on the major autolysin of E. faecalis, AtlA, and a stress-induced protein, SalB, Emily K. Stinemetz

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EVALUATING THE THERAPEUTIC EFFICACY OF RESTORING WILD-TYPE P53 ACTIVITY IN P53-MUTANT TUMORS, Connie A. Larsson

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FRET-Based Investigations of the Structure-Function Relationships in the NMDA Receptor, Drew M. Dolino

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FUNCTIONAL ASYMMETRY OF THE IMMUNE CELL PLASMA MEMBRANE, Eric Malmberg

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Functional consequences of RNA exosome complex alteration by conformational changes and cofactor binding, Jaeil Han

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FURTHER ADVANCES FOR THE SEQUENTIAL MULTIPLE ASSIGNMENT RANDOMIZED TRIAL (SMART), TIANJIAO DAI

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Gcn5 Impacts FGF Signaling At Multiple Levels And Activates C-Myc Target Genes During Early Differentiation Of Embryoid Bodies, Li Wang

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Genesurance Counseling: Patient Perspectives, Chelsea Wagner

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GSK3B regulates epithelial-mesenchymal transition and cancer stem cell properties and is a novel drug target for triple-negative breast cancer, Geraldine Vidhya Raja

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HIGH-THROUGHPUT MAPPING OF THE BIOLOGICAL EFFECTS OF PARTICLE THERAPY, Lawrence Bronk

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HSP27 AND CHEMOTHERAPY-INDUCED AUTOPHAGY AS BIOMARKERS IN OSTEOSARCOMA, John Andrew Livingston

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IDENTIFYING THE IMMUNE RELATED METABOLIC PROPERTIES OF PANCREATIC CANCER USING NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND DYNAMIC MAGNETIC RESONANCE SPECTROSCOPIC IMAGING WITH HYPERPOLARIZED PYRUVATE, Joseph Weygand

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Image Registration to Map Endoscopic Video to Computed Tomography for Head and Neck Radiotherapy Patients, William S. Ingram

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IMPACT OF KRAS/NRAS MUTATIONAL HETEROGENEITY ON CLINICAL OUTCOMES IN COLORECTAL CANCER, Jonathan M. Loree

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Improvements in four-dimensional and dual energy computed tomography, Rachael M. Martin

Improvements in Robustness and Optimality of Intensity-Modulated Proton Therapy Plans for Lung Cancer Patients with 4-Dimensional Robust Optimization, shuaiping ge

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IMPROVING NK CELL THERAPY FOR OSTEOSARCOMA, Jennifer Foltz

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INSIGHTS INTO THE THERAPEUTIC POTENTIAL OF SALT INDUCIBLE KINASE 1: A NOVEL MECHANISM OF METABOLIC CONTROL, Randi Fitzgibbon

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INTEGRATIVE ANALYSIS OF OMICS DATA IN ADULT GLIOMA AND OTHER TCGA CANCERS TO GUIDE PRECISION MEDICINE, Xin hu and xin hu

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INTEGRATIVE CANCER IMMUNOGENOMIC ANALYSIS OF SERIAL MELANOMA BIOPSIES REVEALS CORRELATES OF RESPONSE AND RESISTANCE TO SEQUENTIAL CTLA-4 AND PD-1 BLOCKADE TREATMENT, Whijae Roh

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Investigating the Neural Basis of Audiovisual Speech Perception with Intracranial Recordings in Humans, Muge O. Sertel

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INVESTIGATING THE ROLE OF PRMT1 AND ARGININE METHYLATION OF HSP70 IN HUMAN PANCREATIC CANCER, Liang Wang

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INVESTIGATION OF THE ROLES OF ASF1 AND CAF-1-MEDIATED CHROMATIN ASSEMBLY IN THE HUMAN DNA DAMAGE RESPONSE, Ting-Hsiang Huang

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INVOLVEMENT OF THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS (RAGE) IN PROGRESSION OF PANCREATIC CANCER, Nancy Azizian MS

LBPI: A WEB INTERFACE FOR THE IDENTIFICATION OF ALLOSTERIC LIGAND BINDING SITES, Nabina Paudyal

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LBPI: A WEB INTERFACE FOR THE IDENTIFICATION OF ALLOSTERIC LIGAND BINDING SITES, Nabina Paudyal

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MANAGING VARIANT DISCREPANCY IN HEREDITARY CANCER: CLINICAL PRACTICE, BARRIERS, AND DESIRED RESOURCES, Ellen Zirkelbach