The Jan and Dan Duncan Neurological Institute is home to 37 Principal Investigators, more than 400+ scientists and 10 Core labs.
Dan and Duncan Neurological Institute also house the Gordon and Mary Cain Pediatric Neurology Research Foundation Laboratories which are focused on epilepsy research and Baylor College's of Medicine's Center for Drug Discovery which is aimed at quick identification and advancement of small molecules to clinical trials.
Since inception, more than 1700 scientific studies have been published, and more than 85 disease-causing genetic mutations have been discovered or co-discovered by our scientists. There are currently 6 active clinical trials and studies.
Submissions from 2022
Identification of Risk Genes for Alzheimer’s Disease by Gene Embedding, Yashwanth Lagisetty, Thomas Bourquard, Ismael Al-Ramahi, et al.
A Combined Conduit-Bioactive Hydrogel Approach for Regeneration of Transected Sciatic Nerves, Cheuk Sun Edwin Lai, Viridiana Leyva-Aranda, Victoria H Kong, et al.
Comparison of Treadmill Gait Between a Pediatric-Aged Individual With SYNGAP1-Related Intellectual Disability and a Fraternal Twin, Charles S Layne, Christopher A Malaya, David R Young, et al.
Cross-Species Genetic Screens Identify Transglutaminase 5 as a Regulator of Polyglutamine-Expanded Ataxin-1, Won-Seok Lee, Ismael Al-Ramahi, Hyun-Hwan Jeong, et al.
Neurobehavioral Deficits and a Progressive Ictogenesis in the Tetrodotoxin Model of Epileptic Spasms, John T Le, Carlos J Ballester-Rosado, James D Frost, et al.
Kctd7 Deficiency Induces Myoclonic Seizures Associated With Purkinje Cell Death and Microvascular Defects, Justine H Liang, Jonathan Alevy, Viktor Akhanov, et al.
Fly Cell Atlas: A Single-Nucleus Transcriptomic Atlas of the Adult Fruit Fly, Hongjie Li, Jasper Janssens, Maxime De Waegeneer, et al.
The Allergy Mediator Histamine Confers Resistance to Immunotherapy in Cancer Patients via Activation of the Macrophage Histamine Receptor H1, Hongzhong Li, Yi Xiao, Qin Li, et al.
Causal Evidence for a Role of Cerebellar Lobulus Simplex in Prefrontal-Hippocampal Interaction in Spatial Working Memory Decision-Making, Yu Liu, Samuel S McAfee, Meike E Van Der Heijden, et al.
Loss-of-Function Variants in TIAM1 Are Associated With Developmental Delay, Intellectual Disability, and Seizures, Shenzhao Lu, Rebecca Hernan, Paul C Marcogliese, et al.
De Novo Variants in FRMD5 Are Associated With Developmental Delay, Intellectual Disability, Ataxia, and Abnormalities of Eye Movement, Shenzhao Lu, Mengqi Ma, Xiao Mao, et al.
Sensory Processing Phenotypes in Phelan-McDermid Syndrome and SYNGAP1-Related Intellectual Disability, Ariel M Lyons-Warren, Maria C McCormack, and Jimmy L Holder
Cluster Analysis of Short Sensory Profile Data Reveals Sensory-Based Subgroups in Autism Spectrum Disorder, Ariel M Lyons-Warren, Michael F Wangler, and Ying-Wooi Wan
Sex-Specific Epigenetic Development in the Mouse Hypothalamic Arcuate Nucleus Pinpoints Human Genomic Regions Associated With Body Mass Index, Harry MacKay, Chathura J Gunasekara, Kit-Yi Yam, et al.
Lower Fetal Fraction in Clinical Cell-Free DNA (cfDNA) Screening Results is Associated with Increased Risk of Hypertensive Disorders of Pregnancy, Deeksha Madala, Mohamad Ali Maktabi, Riwa Sabbagh, et al.
PRUNE1 c933G>A Synonymous Variant Induces Exon 7 Skipping, Disrupts the DHHA2 Domain, and Leads to an Atypical NMIHBA Syndrome Presentation: Case Report and Review of the Literature, Christina L Magyar, David R Murdock, Lindsay C Burrage, et al.
‘Fly-ing’ From Rare to Common Neurodegenerative Disease Mechanisms, Mengqi Ma, Matthew J Moulton, Shenzhao Lu, et al.
De Novo FZR1 Loss-of-Function Variants Cause Developmental and Epileptic Encephalopathies, Sathiya N Manivannan, Jolien Roovers, Noor Smal, et al.
Drosophila Functional Screening of De Novo Variants in Autism Uncovers Damaging Variants and Facilitates Discovery of Rare Neurodevelopmental Diseases, Paul C Marcogliese, Samantha L Deal, Jonathan Andrews, et al.
Loss of IRF2BPL Impairs Neuronal Maintenance Through Excess Wnt Signaling, Paul C Marcogliese, Debdeep Dutta, Shrestha Sinha Ray, et al.
Why Study Mechanisms of Brain Stimulation Therapies? To Modulate the Right Neurons, in the Right Way, at the Right Time, Matthew J McGinley and Steven T Lee
Discovery of Potent BET Bromodomain 1 Stereoselective Inhibitors Using DNA-Encoded Chemical Library Selections, Ram K Modukuri, Zhifeng Yu, Zhi Tan, et al.
Cleavage Stimulating Factor 64 Depletion Mitigates Cardiac Fibrosis Through Alternative Polyadenylation, Rahul Neupane, Keith Youker, Hari Krishna Yalamanchili, et al.
Expression of 4E-BP1 in Juvenile Mice Alleviates mTOR-Induced Neuronal Dysfunction and Epilepsy, Lena H Nguyen, Youfen Xu, Travorn Mahadeo, et al.
Notch Missense Mutations in Drosophila Reveal Functions of Specific EGF-like Repeats in Notch Folding, Trafficking, and Signaling, Hilman Nurmahdi, Mao Hasegawa, Elzava Yuslimatin Mujizah, et al.