The Jan and Dan Duncan Neurological Institute is home to 37 Principal Investigators, more than 400+ scientists and 10 Core labs.
Dan and Duncan Neurological Institute also house the Gordon and Mary Cain Pediatric Neurology Research Foundation Laboratories which are focused on epilepsy research and Baylor College's of Medicine's Center for Drug Discovery which is aimed at quick identification and advancement of small molecules to clinical trials.
Since inception, more than 1700 scientific studies have been published, and more than 85 disease-causing genetic mutations have been discovered or co-discovered by our scientists. There are currently 6 active clinical trials and studies.
Submissions from 2023
Compound Heterozygosity of a De Novo Submicroscopic Deletion and an Inherited Frameshift Pathogenic Variant in the PKHD1 Gene in a Fetus With Bilaterally Enlarged and Echogenic Kidneys, Enlarged Abdomen and Oligohydramnios, Takuya Sakyu, Samantha R Stover, Yue Wang, et al.
RagD Auto-Activating Mutations Impair MIT/TFE Activity in Kidney Tubulopathy and Cardiomyopathy Syndrome, Irene Sambri, Marco Ferniani, Giulia Campostrini, et al.
Potential and Pitfalls of Pharmacovigilance Databases in Oncology, Ilana Schlam, Michael S Ewer, and Sandra M Swain
Glia-Neuron Coupling via a Bipartite Sialylation Pathway Promotes Neural Transmission and Stress Tolerance IGlia-Neuron Coupling via a Bipartite Sialylation Pathway Promotes Neural Transmission and Stress Tolerance in Drosophila, Hilary Scott, Boris Novikov, Berrak Ugur, et al.
PIEZO2 in Somatosensory Neurons Controls Gastrointestinal Transit, M Rocio Servin-Vences, Ruby M Lam, Alize Koolen, et al.
The Role of Pharmacotherapy in Treatment of Meningioma: A Systematic Review, Ataollah Shahbandi, Darsh S Shah, Caroline C Hadley, et al.
A Clustering of Heterozygous Missense Variants in the Crucial Chromatin Modifier WDR5 Defines a New Neurodevelopmental Disorder, Lot Snijders Blok, Jolijn Verseput, Dmitrijs Rots, et al.
New Mouse Models With Hypomorphic SUMF1 Variants Mimic Attenuated Forms of Multiple Sulfatase Deficiency, Nicolina Cristina Sorrentino, Maximiliano Presa, Sergio Attanasio, et al.
SPTSSA Variants Alter Sphingolipid Synthesis and Cause a Complex Hereditary Spastic Paraplegia, Siddharth Srivastava, Hagar Mor Shaked, Kenneth Gable, et al.
Mutations in the Transcriptional Regulator MeCP2 Severely Impact Key Cellular and Molecular Signatures of Human Astrocytes During Maturation, Jialin Sun, Sivan Osenberg, Austin Irwin, et al.
Bi-Allelic Variants in INTS11 Are Associated With a Complex Neurological Disorder, Burak Tepe, Erica L Macke, Marcello Niceta, et al.
A Recombinant Protein XBB15 RBD/Alum/CpG Vaccine Elicits High Neutralizing Antibody Titers against Omicron Subvariants of SARS-CoV-2, Syamala Rani Thimmiraju, Rakesh Adhikari, Maria Jose Villar, et al.
A Drosophila Model Relevant to Chemotherapy-Related Cognitive Impairment, Matthew Torre, Hassan Bukhari, Vanitha Nithianandam, et al.
A Comprehensive and Integrative Approach to MeCP2 Disease Transcriptomics, Alexander J Trostle, Lucian Li, Seon-Young Kim, et al.
The Lysosomal Ragulator Complex Activates NLRP3 Inflammasome In Vivo via HDAC6, Kohei Tsujimoto, Tatsunori Jo, Daiki Nagira, et al.
Anoctamin 4 Channel Currents Activate Glucose-Inhibited Neurons in the Mouse Ventromedial Hypothalamus During Hypoglycemia, Longlong Tu, Jonathan C Bean, Yang He, et al.
International Society for Prenatal Diagnosis 2022 Debate 3-Fetal Genome Sequencing Should Be Offered to All Pregnant Patients, Ignatia B Van den Veyver, Yuval Yaron, and Zandra C Deans
Glutamatergic Cerebellar Neurons Differentially Contribute to the Acquisition of Motor and Social Behaviors, Meike E van der Heijden, Alejandro G Rey Hipolito, Linda H Kim, et al.
Cerebellar Dysfunction in Rodent Models With Dystonia, Tremor, and Ataxia, Meike E van der Heijden and Roy V Sillitoe
Labeling PIEZO2 Activity in the Peripheral Nervous System, Nicholas W Villarino, Yasmeen M F Hamed, Britya Ghosh, et al.
Studying Ultra-Rare Variants in STX1A Uncovers a Novel Neurodevelopmental Disorder, Esmeralda Villavicencio Gonzalez and Ryan S Dhindsa
Daam2 Phosphorylation by CK2α Negatively Regulates Wnt Activity During White Matter Development and Injury, Chih-Yen Wang, Zhongyuan Zuo, Juyeon Jo, et al.
CoRegNet: Unraveling Gene Co-Regulation Networks from Public RNA-Seq Repositories Using a Beta-Binomial Statistical Model, Jiasheng Wang, Ying-Wooi Wan, Rami Al-Ouran, et al.
Dicarboxylic Acylcarnitine Biomarkers in Peroxisome Biogenesis Disorders, Michael F Wangler, Barbara Lesko, Rejwi Dahal, et al.
Unravelling Spatial Gene Associations With SEAGAL: A Python Package for Spatial Transcriptomics Data Analysis and Visualization, Linhua Wang, Chaozhong Liu, Yang Gao, et al.