The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2022
Control of SARS-CoV-2 Infection by MT1-Mmp-Mediated Shedding of ACE2, Xuanming Guo, Jianli Cao, Jian-Piao Cai, et al.
Correlations Between Complex Human Phenotypes Vary by Genetic Background, Gender, and Environment, Michael Elgart, Matthew O Goodman, Carmen Isasi, et al.
Engineering Antibody and Protein Therapeutics to Cross the Blood-Brain Barrier, Peng Zhao, Ningyan Zhang, and Zhiqiang An
Exome Array Analysis of 9721 Ischemic Stroke Cases from the SiGN Consortium, Huichun Xu, Kevin Nguyen, Brady J Gaynor, et al.
Expression of P-STAT3 and C-Myc Correlates With P2-HNF4α Expression in Nonalcoholic Fatty Liver Disease (NAFLD), Mamoun Younes, Lin Zhang, Baharan Fekry, et al.
Fulminant Lung Fibrosis In Non-Resolvable COVID-19 Requiring Transplantation, Soma S K Jyothula, Andrew Peters, Yafen Liang, et al.
Genome-Wide Meta-Analyses Reveal Novel Loci For Verbal Short-Term Memory and Learning, Jari Lahti, Samuli Tuominen, Qiong Yang, et al.
Hepatic Circadian and Differentiation Factors Control Liver Susceptibility For Fatty Liver Disease and Tumorigenesis, Baharan Fekry, Aleix Ribas-Latre, Rachel Van Drunen, et al.
High-Contrast Detection of Somatostatin Receptor Subtype-2 for Fluorescence-Guided Surgery, Servando Hernandez Vargas, Solmaz AghaAmiri, Sukhen C Ghosh, et al.
Identification of Novel Susceptibility Methylation Loci for Pancreatic Cancer in a Two-Phase Epigenome-Wide Association Study, Ziqiao Wang, Yue Lu, Myriam Fornage, et al.
Indications For Absorbable Steroid-Eluting Sinus Implants: Viewpoint Via The Delphi Method, Victoria S Lee, Prayag Patel, Daniel O'Brien, et al.
Longitudinal Change in Blood DNA Epigenetic Signature After Smoking Cessation, Amena Keshawarz, Roby Joehanes, Weihua Guan, et al.
Metabolic Targeting of NRF2 Potentiates the Efficacy of the TRAP1 Inhibitor G-TPP Through Reduction of ROS Detoxification in Colorectal Cancer, Hong-Yuan Tsai, Mary P Bronner, Jordon K March, et al.
mRatBN72: Familiar and Unfamiliar Features of a New Rat Genome Reference Assembly, Tristan V de Jong, Hao Chen, Wesley A Brashear, et al.
MRI Free Water as a Biomarker for Cognitive Performance: Validation in the MarkVCID Consortium, Pauline Maillard, Laura J Hillmer, Hanzhang Lu, et al.
Rare Genetic Variants Explain Missing Heritability in Smoking, Seon-Kyeong Jang, Luke Evans, Allison Fialkowski, et al.
Selective IgA Deficiency in Spontaneously Hypertensive Rats With Gut Dysbiosis, Piu Saha, Blair Mell, Rachel M Golonka, et al.
SIRPα Mediates IGF1 Receptor in Cardiomyopathy-Induced by Chronic Kidney Disease, Sandhya S Thomas, Jiao Wu, Giovanni Davogustto, et al.
Temporal and Spatial Metabolite Dynamics Impart Control in Adipogenesis, Kristin Eckel-Mahan
The Challenges and Opportunities of scRNA-Seq in COVID-19 Research and Clinical Translation, Wendao Liu, Xiaohua Ye, Zhiqiang An, et al.
The Circular RNA Edis Regulates Neurodevelopment and Innate Immunity, Xiao-Peng Xiong, Weihong Liang, Wei Liu, et al.
The Rheumatoid Arthritis Drug Auranofin Lowers Leptin Levels and Exerts Antidiabetic Effects in Obese Mice, Aaron R Cox, Peter M Masschelin, Pradip K Saha, et al.
Uncloaking Cell-Impermeant Gold Nanorods Via Tumor Microenvironmental Cathepsin B Facilitates Cancer Cell Penetration and Potent Radiosensitization, Subhiksha Raghuram, Yuri Mackeyev, Jessica Symons, et al.
Whole Genome Sequence Analysis of Blood Lipid Levels in >66,000 Individuals, Margaret Sunitha Selvaraj, Xihao Li, Zilin Li, et al.
Whole Genome Sequencing Identifies Structural Variants Contributing to Hematologic Traits in the Nhlbi topmed Program, Marsha M Wheeler, Adrienne M Stilp, Shuquan Rao, et al.