The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2026
Adipocyte-Specific Deletion of Sine Oculis Homeobox Homolog 1 Inhibits Lipolysis and Reduces Skin Fibrosis, Nancy Wareing, Tingting W Mills, Scott Collum, et al.
Blood Flow Regulates Metabolism in Hematopoietic Development, Pamela L Wenzel
Brain-Engrafted Monocyte-Derived Macrophages From Blood and Skull-Bone Marrow Exhibit Distinct Properties, Siling Du, Feiya Ou, Antoine Drieu, et al.
CD44v9 as a Therapeutic Target for Antibody-Drug Conjugate in Advanced Breast Cancer, Dileep R Reddy, McKenna E Flynn, Yasuaki Anami, et al.
Does HLA-B27 Status Influence Ixekizumab Efficacy in Axial Spondyloarthritis? Results From the COAST-V, COAST-W, and COAST-X Trials, John D Reveille, Martin Rudwaleit, Proton Rahman, et al.
Ectopic B Lymphocyte Follicles Exacerbate Ischemic Brain Damage via MIF-CD74/CXCR4 and Interferon Signaling, Sheng Yang, Hang Zhang, Lu-Lu Xu, et al.
Estimating Population Structure Using Epigenome-Wide Methylation Data, Ziqing Wang, Kent D Taylor, Jerome I Rotter, et al.
Freeze-Dried, Not Frozen: Lyophilized Mesenchymal Stromal Cell-Derived Extracellular Vesicles and Therapeutic Function in Neuroinflammatory Models, Janet R Ashley, Aidan M Collier, Scott D Olson, et al.
Genome-Wide Gene-Sleep Interaction Study Identifies Novel Lipid Loci in 732,564 Participants, Raymond Noordam, Wenyi Wang, Pavithra Nagarajan, et al.
Human-centered Design of Patient Interviews: Capturing the Experiences of Patients Recovering From Emergency Abdominal Surgery, Jenna L Marquard, Christie L Martin, Elizabeth C Wick, et al.
Human Microglia in Brain Assembloids Display Region-Specific Diversity and Respond to Hyperexcitable Neurons Carrying SCN2A Mutation, Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, et al.
Identification of a Cytokine Biomarker for Prognostic Modeling of Breast Cancer-Related Lymphedema, Alison J Wu, Neil Lin, Jie Su, et al.
Large-Scale Blood Pressure Gwas Accounting for Gene-Depression Interactions in 564,680 Individuals From Diverse Populations, Songmi Lee, Clint L Miller, Amy R Bentley, et al.
Mechanometabolism Instructs Hematopoietic Stem Cell Specification, Paulina D Horton, Alina Syed, Michelle Winkler, et al.
Neutralization of SARS-CoV-2 by IgM-14 via Engagement of Two Distinct Spike Epitopes, Yan Wang, Yanping Hu, Zhiqiang Ku, et al.
Neutrophil-Microglia Interaction Drives Motor Dysfunction in a Neuromyelitis Optica Model Induced by Subarachnoid AQP4-IgG, Fangfang Qi, Vanda A Lennon, Shunyi Zhao, et al.
Selective Deletion of FGFR1 in AgRP Neurons Impairs Energy Homeostasis Under High-Fat Diet in Mice, Daniel Shookster, Shea O'Connell, Patel Darshan, et al.
Single Ventricle Physiology May Not Preclude Cardiac Repair in the Setting of Congenital Diaphragmatic Hernia, Kylie I Holden, Michael C Scott, Ashley H Ebanks, et al.
Structural-Functional Analyses of the Huntingtin/HAP40 Complex in Drosophila and Humans, Stephen M Farmer, Amanda Solbach, Shiyu Xu, et al.
SUPT16H-Associated Neurodevelopmental Disorder and Neurocristopathy: Genetic and Phenotypic Spectrum, Eunhye Lee, Seungmin Sim, Hee-Jung Choi, et al.
The Neuroprotective Effects of Alpha-Tocopherol as an Anti-Inflammatory Agent: Mechanistic Insights and Therapeutic Challenges, Megumi H Seese and Yuanzhong Xu
Transfusion in Transit: A Decade of Prehospital Blood Transfusion in Pediatric Trauma, Krysta M Sutyak, Eunise C Chen, Lea Mock, et al.
γδ T Cells at the Interface of Innate and Adaptive Immunity in Cancer, Arnau Solé Casaramona, Martin F Bachmann, Eva Sevick-Muraca, et al.
Submissions from 2025
Acute Kidney Injury Is Associated With Elevated Urinary Endotrophin, Amanda J Clark, Brenda Mendoza Flores, Marie Christelle Saade, et al.
Additional Evidence From a Case Report Supports a Novel Hypothesis on the Association Between Complex Regional Pain Syndrome and Lymphedema, M Mark Melin, John C Rasmussen, Melissa B Aldrich, et al.