The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2025
Additional Evidence From a Case Report Supports a Novel Hypothesis on the Association Between Complex Regional Pain Syndrome and Lymphedema, M Mark Melin, John C Rasmussen, Melissa B Aldrich, et al.
Aging in Mice Alters Regionally Enriched Striatal Astrocytes, Kay E Linker, Violeta Duran-Laforet, Matthias Ollivier, et al.
An Alternative Neural Basis Underlying Leptin Resistance, Hongli Li, Cunjin Su, Yuanzhong Xu, et al.
An Intranasally Administered IgM Protects Against Antigenically Distinct Subtypes of Influenza a Viruses, Ashwin Kumar Ramesh, Jwala Priyadarsini Sivaccumar, Xiaohua Ye, et al.
Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer, Joan Jacob, Yasuaki Anami, Peyton C High, et al.
Anti-Tumor Activity of Camptothecin Analog Conjugate of an RSPO4-Based Peptibody Targeting LGR4/5/6 in Preclinical Models of Colorectal Cancer, Yukimatsu Toh, Ling Wu, Jianghua Tu, et al.
Association of Epigenetic Aging With Plasma Cbiomarkers of Amyloid, Tau, Neurodegeneration, and Neuroinflammation in Hispanic/Latino Adults, Myriam Fornage, Wassim Tarraf, Martha L Daviglus, et al.
Association of Genetic Scores Related to Insulin Resistance With Neurological Outcomes in Ancestrally Diverse Cohorts From the Trans-Omics for Precision Medicine (TOPMed) Program, Chloé Sarnowski, Yixin Zhang, Farah Ammous, et al.
A Statistical Framework for Multi-Trait Rare Variant Analysis in Large-Scale Whole-Genome Sequencing Studies, Xihao Li, Han Chen, Margaret Sunitha Selvaraj, et al.
A Sumo-Interacting Motif in the Guanine Nucleotide Exchange Factor EPAC1 Is Required for Subcellular Targeting and Function, Wenli Yang, Fang Mei, Wei Lin, et al.
A Switch Protein Adapter for Anti-LILRB4 CAR-T Cells, Ryan Huang, Heyu Chen, Jingjing Xie, et al.
Bile Acid Regulation of Xenobiotic Nuclear Receptors on the Expressions of Orosomucoids in the Liver, Ji Ho Suh, Inyoung Cheon, Hyun-Jung Jung, et al.
Caloric Restriction and Telomere Preservation in TERT Knockout Adipocyte Progenitors Does Not Rescue Mice From Metabolic Dysfunction due to a TERT Function in Adipocyte Mitochondria., Zhanguo Gao, Yongmei Yu, Kristin Eckel-Mahan, et al.
Cetuximab Increases LGR5 Expression and Augments LGR5-Targeting Antibody-Drug Conjugate Efficacy in Patient-Derived Colorectal Cancer Models, Peyton C High, Zhengdong Liang, Cara Guernsey-Biddle, et al.
Chemogenetic Activation of Microglial Gi Signaling Decreases Microglial Surveillance and Impairs Neuronal Synchronization, Shunyi Zhao, Lingxiao Wang, Dimitrios Kleidonas, et al.
Complement Activity and Autophagy Are Dysregulated in the Lungs of Patients With Nonresolvable COVID-19 Requiring Lung Transplantation, Pooja Shivshankar, Stacey L Mueller-Ortiz, Aleksey Y Domozhirov, et al.
Complete Genomic Characterization of Global Pathogens Respiratory Syntical Virus and Human Norovirus Using Probe Based Capture Enrichment, Sravya V Bhamidipati, Anil Surathu, Hsu Chao, et al.
Decreased Proliferation of HepG2 Liver Cancer Cells In Vitro and Exhibited Proteomic Changes In Vivo in Subjects With Metabolic Syndrome and Metabolic Dysfunction-Associated Steatotic Liver Disease Who Performed Four-Week Dawn-to-Dusk Dry Fasting, Ayse L Mindikoglu, Kristin Eckel-Mahan, Antone R Opekun, et al.
DNA Methylation Markers of Insulin Resistance Surrogate Measures in the Atherosclerosis Risk in Communities (ARIC) Study, Jeewoen Shin, Jan Bressler, Megan L Grove, et al.
DNA-PK Inhibition Sustains the Antitumor Innate Immune Response in Small Cell Lung Cancer, Caterina De Rosa, Floriana Morgillo, Luisa Amato, et al.
Enhanced Anticancer Activity of Novel Pyrimidine Nucleoside Analog in Pancreatic Cancer, Raviteja Bulusu, Joy Okoro, Esther Frimpong, et al.
Epac1 Deletion Attenuates Müller Glial Pathological Activation and Mitigates Retinal Neurodegeneration in Ischemia-Induced Retinopathy, Shuizhen Shi, Fan Xia, Zhongqiao Lu, et al.
Epigenome-Wide DNA Methylation Association Study of Chip Provides Insight Into Perturbed Gene Regulation, Sara Kirmani, Tianxiao Huan, Joseph C Van Amburg, et al.
Escape of Kdm6a from X Chromosome Is Detrimental to Ischemic Brains via IRF5 Signaling, Conelius Ngwa, Afzal Misrani, Kanaka Valli Manyam, et al.
Functional Characterization of QT Interval Associated SCN5A Enhancer Variants Identify Combined Additive Effects, Lavanya Gunamalai, Parul Singh, Brian Berg, et al.