The HCOA was formed in 1988 by the generosity of the late ">Roy M. and Phyllis Gough Huffington, Houston philanthropists who foresaw the need for an academic entity devoted to studying aging, providing care for older people, and teaching future health professionals and researchers about geriatrics and gerontology.
The Roy M. and Phyllis Gough Huffington Center on Aging spearheads breakthrough research and is committed to translating basic research discoveries into applications that promote healthy aging and combat age-associated disorders. The faculty, along with their research staff and trainees, utilize diverse model systems and multidisciplinary approaches to address questions that are of crucial importance to the biology, pathophysiology and diseases of aging. The major research topics include lifespan and health span studies, aging of the endocrine, vasculature, and central nervous systems, cancer, and neurodegenerative diseases, in particular Alzheimer’s disease..
Submissions from 2023
Toll-Like Receptor 4 and CD11b Expressed on Microglia Coordinate Eradication of Candida albicans Cerebral Mycosis, Yifan Wu, Shuqi Du, Lynn H Bimler, et al.
Toward Quantification of Hypoxia Using Fluorinated EuII/III-Containing Ratiometric Probes, S A Amali S Subasinghe, Caitlyn J Ortiz, Jonathan Romero, et al.
Utilizing Speech Analysis to Differentiate Progressive Supranuclear Palsy From Parkinson’s Disease, Kyurim Kang, Adonay S Nunes, Mansi Sharma, et al.
Vitamin B2 Enables Regulation of Fasting Glucose Availability, Peter M Masschelin, Pradip Saha, Scott A Ochsner, et al.
Submissions from 2022
A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians, Ruyang Zhang, Sipeng Shen, Yongyue Wei, et al.
A Mouse Holder for Awake Functional Imaging in Unanesthetized Mice: Applications in 31P Spectroscopy, Manganese-Enhanced Magnetic Resonance Imaging Studies, and Resting-State Functional Magnetic Resonance Imaging, Lindsay C Fadel, Ivany V Patel, Jonathan Romero, et al.
An Asian Case of Combined 17α-Hydroxylase/17,20-Lyase Deficiency Due to Homozygous p.R96Q Mutation: A Case Report and Review of the Literature, Qian Liao, Rufei Shen, Mingyu Liao, et al.
A Potential Role for Substance P in West Nile Virus Neuropathogenesis, Shannon E Ronca, Sarah M Gunter, Rebecca Berry Kairis, et al.
Association between Fall History and Gait, Balance, Physical Activity, Depression, Fear of Falling, and Motor Capacity: A 6-Month Follow-Up Study, Catherine Park, Md Moin Uddin Atique, Ramkinker Mishra, et al.
Atomic Structure of the Leishmania spp Hsp100 N-domain, Jonathan M Mercado, Sukyeong Lee, Changsoo Chang, et al.
cGAS-Sting Activation Contributes to Podocyte Injury in Diabetic Kidney Disease, Nan Zang, Chen Cui, Xinghong Guo, et al.
Chronic Exposure to Carbon Black Ultrafine Particles Reprograms Macrophage Metabolism and Accelerates Lung Cancer, Cheng-Yen Chang, Ran You, Dominique Armstrong, et al.
Clinical Characteristics and Associated Factors of Colonic Polyps in Acromegaly, Guiliang Peng, Xing Li, Yuanyuan Zhou, et al.
Common Genomic Aberrations in Mouse and Human Breast Cancers with Concurrent P53 Deficiency and Activated PTEN-PI3K-AKT Pathway, Jarrod D Martinez, Qianxing Mo, Yixiang Xu, et al.
Concerted Type I Interferon Signaling in Microglia and Neural Cells Promotes Memory Impairment Associated With Amyloid β Plaques, Ethan R Roy, Gabriel Chiu, Sanming Li, et al.
Digital Biomarkers of Gait and Balance in Diabetic Foot, Measurable by Wearable Inertial Measurement Units: A Mini Review, Gu Eon Kang, Angeloh Stout, Ke'Vaughn Waldon, et al.
Genome Sequencing in the Parkinson Disease Clinic, Emily J Hill, Laurie A Robak, Rami Al-Ouran, et al.
High-Throughput Profiling of Histone Post-Translational Modifications and Chromatin Modifying Proteins by Reverse Phase Protein Array, Xuan Wang, Zhongcheng Shi, Hsin-Yi Lu, et al.
Identification of Risk Genes for Alzheimer’s Disease by Gene Embedding, Yashwanth Lagisetty, Thomas Bourquard, Ismael Al-Ramahi, et al.
Imaging-Based Screening of Deubiquitinating Proteases Identifies Otubain-1 as a Stabilizer of c-MYC, Shannon E Moree, Laure Maneix, Polina Iakova, et al.
In Alzheimer-Prone Brain Regions, Metabolism and Risk-Gene Expression Are Strongly Correlated, Fengdan Ye, Quentin Funk, Elijah Rockers, et al.
Isolation and RNA Sequencing of Single Nuclei From Drosophila Tissues, Colleen N McLaughlin, Yanyan Qi, Stephen R Quake, et al.
Neuronal Signal-Regulatory Protein Alpha Drives Microglial Phagocytosis by Limiting Microglial Interaction With CD47 in the Retina, Danye Jiang, Courtney A Burger, Viktor Akhanov, et al.
Non-Canonical Odor Coding in the Mosquito, Margaret Herre, Olivia V Goldman, Tzu-Chiao Lu, et al.
Objective Assessment of Upper-Extremity Motor Functions in Spinocerebellar Ataxia Using Wearable Sensors, Reza Mohammadi-Ghazi, Hung Nguyen, Ram Kinker Mishra, et al.