The HCOA was formed in 1988 by the generosity of the late ">Roy M. and Phyllis Gough Huffington, Houston philanthropists who foresaw the need for an academic entity devoted to studying aging, providing care for older people, and teaching future health professionals and researchers about geriatrics and gerontology.
The Roy M. and Phyllis Gough Huffington Center on Aging spearheads breakthrough research and is committed to translating basic research discoveries into applications that promote healthy aging and combat age-associated disorders. The faculty, along with their research staff and trainees, utilize diverse model systems and multidisciplinary approaches to address questions that are of crucial importance to the biology, pathophysiology and diseases of aging. The major research topics include lifespan and health span studies, aging of the endocrine, vasculature, and central nervous systems, cancer, and neurodegenerative diseases, in particular Alzheimer’s disease..
Submissions from 2024
Research Participants' Perspectives on Precision Diagnostics for Alzheimer's Disease, Hadley Stevens Smith, Jill O Robinson, Ariel Levchenko, et al.
SIRT1 Safeguards Adipogenic Differentiation by Orchestrating Anti-Oxidative Responses and Suppressing Cellular Senescence, An Yu, Ruofan Yu, Haiying Liu, et al.
SOD1 Is a Synthetic-Lethal Target in PPM1D-Mutant Leukemia Cells, Linda Zhang, Joanne I Hsu, Etienne D Braekeleer, et al.
Targeting Histone Deacetylase in Cardiac Diseases, Jiao Lu, Sichong Qian, and Zheng Sun
Tau Is Required for Glial Lipid Droplet Formation and Resistance to Neuronal Oxidative Stress, Lindsey D Goodman, Isha Ralhan, Xin Li, et al.
TFEB Safeguards Trophoblast Syncytialization in Humans and Mice, Wanshan Zheng, Yue Zhang, Peiqun Xu, et al.
TFEB-Vacuolar ATPase Signaling Regulates Lysosomal Function and Microglial Activation in Tauopathy, Baiping Wang, Heidi Martini-Stoica, Chuangye Qi, et al.
The Application of Digital Frailty Screening to Triage Nonhealing and Complex Wounds, Ram Kinker Mishra, Rasha O Bara, Alejandro Zulbaran-Rojas, et al.
The Infected Diabetic Foot: Does Negative Pressure Wound Therapy with Irrigation Reduce Bioburden and Improve Wound Healing?, Mehmet A Suludere, Matthew Malone, Michael C Siah, et al.
The Stress of Measuring Plantar Tissue Stress in People with Diabetes-Related Foot Ulcers: Biomechanical and Feasibility Findings from Two Prospective Cohort Studies, Chantal M Hulshof, Madelyn Page, Sjef G van Baal, et al.
Towards a Remote Patient Monitoring Platform for Comprehensive Risk Evaluations for People with Diabetic Foot Ulcers, Gozde Cay, M G Finco, Jason Garcia, et al.
Transcutaneous Electrical Nerve Stimulation for Fibromyalgia-Like Syndrome in Patients With Long-COVID: A Pilot Randomized Clinical Trial, Alejandro Zulbaran-Rojas, Rasha O Bara, Myeounggon Lee, et al.
Using Patient-Reported Experiences To Inform the Use of Foam Dressings for Hard-To-Heal Wounds: Perspectives From a Wound Care Expert Panel, Kevin Woo, Nick Santamaria, Dimitri Beeckman, et al.
Yeast EndoG Prevents Genome Instability by Degrading Extranuclear DNA Species, Yang Yu, Xin Wang, Jordan Fox, et al.
Submissions from 2023
Advances in Prosthetic Technology: A Perspective on Ethical Considerations for Development and Clinical Translation, Hayden Gavette, Cody L McDonald, Kristin Kostick-Quenet, et al.
Ageing and Rejuvenation of Tissue Stem Cells and Their Niches, Anne Brunet, Margaret A Goodell, and Thomas A Rando
Aging Fly Cell Atlas Identifies Exhaustive Aging Features at Cellular Resolution, Tzu-Chiao Lu, Maria Brbić, Ye-Jin Park, et al.
Animal Models and Their Role in Imaging-Assisted Co-Clinical Trials, Donna M Peehl, Cristian T Badea, Thomas L Chenevert, et al.
Argininosuccinate Lyase Deficiency Causes Blood-Brain Barrier Disruption Via Nitric Oxide-Mediated Dysregulation of Claudin Expression, Jordan Kho, Urszula Polak, Ming-Ming Jiang, et al.
A Split and Inducible Adenine Base Editor for Precise In Vivo Base Editing, Hongzhi Zeng, Qichen Yuan, Fei Peng, et al.
Associations Between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients With Solid Tumors, Sebastià Franch-Expósito, Miika Mehine, Ryan N Ptashkin, et al.
Biochemical and Structural Characterization of the First-Discovered Metazoan DNA Cytosine-N4 Methyltransferase From the Bdelloid Rotifer Adineta vaga, Jujun Zhou, John R Horton, Gundeep Kaur, et al.
Biomechanical Origins of Proprioceptor Feature Selectivity and Topographic Maps in the Drosophila Leg, Akira Mamiya, Anne Sustar, Igor Siwanowicz, et al.
Bladder Mucosal Cystitis Cystica Lesions Are Tertiary Lymphoid Tissues That Correlate With Recurrent Urinary Tract Infection Frequency in Postmenopausal Women, Marianne M Ligon, Brooke Liang, Stacy M Lenger, et al.
Care4AD: A Technology-Driven Platform for Care Coordination and Management: Acceptability Study in Dementia, Ram Kinker Mishra, Catherine Park, Anmol Salim Momin, et al.