The HCOA was formed in 1988 by the generosity of the late ">Roy M. and Phyllis Gough Huffington, Houston philanthropists who foresaw the need for an academic entity devoted to studying aging, providing care for older people, and teaching future health professionals and researchers about geriatrics and gerontology.
The Roy M. and Phyllis Gough Huffington Center on Aging spearheads breakthrough research and is committed to translating basic research discoveries into applications that promote healthy aging and combat age-associated disorders. The faculty, along with their research staff and trainees, utilize diverse model systems and multidisciplinary approaches to address questions that are of crucial importance to the biology, pathophysiology and diseases of aging. The major research topics include lifespan and health span studies, aging of the endocrine, vasculature, and central nervous systems, cancer, and neurodegenerative diseases, in particular Alzheimer’s disease..
Submissions from 2025
The Causal Pivot: A Structural Approach to Genetic Heterogeneity and Variant Discovery in Complex Diseases, Chad A Shaw, C J Williams, Taotao Tan, et al.
The Dialysis Foot- the Impact of Presenting Estimated Glomerular Filtration Rate on Clinical Outcomes in Patients Hospitalized With Diabetic Foot Infections, Arthur Tarricone, Tyler L Coye, Allen Gee, et al.
The HAVCR1-Centric Host Factor Network Drives Zika Virus Vertical Transmission, Wenzhe Yu, Jun Tao, Hongmin Cao, et al.
The Infected Diabetic Foot: Bacteraemia and Endocarditis Complicating Moderate and Severe Foot Infections, Mario C Reyes, Arthur N Tarricone, Mathew J Sideman, et al.
The Infected Diabetic Foot: Incidence and Risk Factors for Dehiscence After Surgery for Diabetic Foot Infections, Lawrence A Lavery, Mario C Reyes, Bijan Najafi, et al.
The Infected Diabetic Foot: Risk Factors for Re-Infection After Treatment for Diabetic Foot Osteomyelitis, Lawrence A Lavery, Mario C Reyes, Bijan Najafi, et al.
Zika Virus NS1 Drives Tunneling Nanotube Formation for Mitochondrial Transfer and Stealth Transmission in Trophoblasts, Rafael T Michita, Long B Tran, Steven J Bark, et al.
Submissions from 2024
Advances in Immunocompetent Mouse and Rat Models, Wen Bu and Yi Li
Aging Atlas Reveals Cell-Type-Specific Effects of Pro-Longevity Strategies, Shihong Max Gao, Yanyan Qi, Qinghao Zhang, et al.
A Light-Responsive Neural Circuit Suppresses Feeding, Hailan Liu, Na Qu, Natalia Valdez Gonzalez, et al.
Alzheimer's Disease Risk Gene CD2AP Is a Dose-Sensitive Determinant of Synaptic Structure and Plasticity, Taeyong Ahn, Gabrielle E Largoza, Julia Younis, et al.
Alzheimer’s Disease Risk Gene CD2AP Is a Dose-Sensitive Determinant of Synaptic Structure and Plasticity, Matea Pavešković, Ruth B De-Paula, Shamsideen A Ojelade, et al.
Assessing the Acceptability and Effectiveness of a Novel Therapeutic Footwear in Reducing Foot Pain and Improving Function among Older Adults: A Crossover Randomized Controlled Trial, M G Finco, Abderrahman Ouattas, Nesreen El-Refaei, et al.
Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells, Mary Elise L Severino, Lauren Richardson, Ananth Kumar Kammala, et al.
Complement C3aR Signaling: Immune and Metabolic Modulation and Its Impact on Alzheimer’s Disease, Manasee Gedam and Hui Zheng
COVID-19 Convalescent Plasma Therapy: Long-Term Implications, Hyunah Yoon, Yi Li, Keith S Goldfeld, et al.
Cyclophilin a Supports Translation of Intrinsically Disordered Proteins and Affects Haematopoietic Stem Cell Ageing, Laure Maneix, Polina Iakova, Charles G Lee, et al.
Dawn-to-Dusk Dry Fasting Decreases Circulating Inflammatory Cytokines in Subjects With Increased Body Mass Index, Zahraa Al Lami, Miray Kurtca, Moin Uddin Atique, et al.
Diabetes Technology Meeting 2023, Tiffany Tian, Rachel E Aaron, Ashley Y DuNova, et al.
D-Mannose Reduces Cellular Senescence and NLRP3/GasderminD/Il-1β-Driven Pyroptotic Uroepithelial Cell Shedding in the Murine Bladder, Chetanchandra S Joshi, Arnold M Salazar, Caihong Wang, et al.
Effects and Plasma Proteomic Analysis of GLP-1RA Versus CPA/EE, in Combination With Metformin, on Overweight PCOS Women: A Randomized Controlled Trial, Mingyu Liao, Xing Li, Hao Zhang, et al.
Efficacy and Feasibility of Intradialytic Plantar Electrical Stimulation in Patients With Diabetes: A Randomized Double-Blind Controlled Trial, Myeounggon Lee, Abdullah Hamad, Mehrnaz Azarian, et al.
Experiences of Midwestern Obstetric Clinicians During the Coronavirus Disease 2019 Pandemic, Drishti D Sinha, Megan Foeller, Abigail S Bell, et al.
Gastrocnemius Electrical Stimulation Increases Ankle Dorsiflexion Strength in Patients With Post-Acute Sequelae of SARS-Cov-2 (Pasc): A Double-Blind Randomized Controlled Trial, Myeounggon Lee, Alejandro Zulbaran-Rojas, Miguel Bargas-Ochoa, et al.
Genetic Deletion of Galectin-3 Inhibits Pancreatic Cancer Progression and Enhances the Efficacy of Immunotherapy, Daowei Yang, Xinlei Sun, Rohan Moniruzzaman, et al.