The HCOA was formed in 1988 by the generosity of the late ">Roy M. and Phyllis Gough Huffington, Houston philanthropists who foresaw the need for an academic entity devoted to studying aging, providing care for older people, and teaching future health professionals and researchers about geriatrics and gerontology.
The Roy M. and Phyllis Gough Huffington Center on Aging spearheads breakthrough research and is committed to translating basic research discoveries into applications that promote healthy aging and combat age-associated disorders. The faculty, along with their research staff and trainees, utilize diverse model systems and multidisciplinary approaches to address questions that are of crucial importance to the biology, pathophysiology and diseases of aging. The major research topics include lifespan and health span studies, aging of the endocrine, vasculature, and central nervous systems, cancer, and neurodegenerative diseases, in particular Alzheimer’s disease..
Submissions from 2024
Harnessing Physical Activity Monitoring and Digital Biomarkers of Frailty From Pendant Based Wearables to Predict Chemotherapy Resilience in Veterans With Cancer, Gozde Cay, Yvonne H Sada, Mohammad Dehghan Rouzi, et al.
Harnessing Speech-Derived Digital Biomarkers to Detect and Quantify Cognitive Decline Severity in Older Adults, Gozde Cay, Valeria A Pfeifer, Myeounggon Lee, et al.
Hematologic DNMT3A Reduction and High-Fat Diet Synergize To Promote Weight Gain and Tissue Inflammation, Jaime M Reyes, Ayala Tovy, Linda Zhang, et al.
How Should Clinical Wound Care and Management Translate to Effective Engineering Standard Testing Requirements from Foam Dressings? Mapping the Existing Gaps and Needs, Amit Gefen, Paulo Alves, Dimitri Beeckman, et al.
Human Embryonic Genetic Mosaicism and Its Effects on Development and Disease, Sarah M Waldvogel, Jennifer E Posey, and Margaret A Goodell
IFRD1 Is Required for Maintenance of Bladder Epithelial Homeostasis, Bisiayo E Fashemi, Amala K Rougeau, Arnold M Salazar, et al.
Incipient Clonal Hematopoiesis Is Accelerated Following CD30.CAR-T Therapy, Chiraag D Kapadia, Gerardo Rosas, Sachin G Thakkar, et al.
MATES: A Deep Learning-Based Model for Locus-Specific Quantification of Transposable Elements in Single Cell, Ruohan Wang, Yumin Zheng, Zijian Zhang, et al.
Methicillin-Resistant Staphylococcus aureus in Diabetic and Non-diabetic Foot Infections, Lawrence A Lavery, Mario C Reyes, Mehmet Suludere, et al.
Mutant NPM1 Marginally Impacts Ribosome Footprint in Acute Myeloid Leukemia Cells, Lorenzo Brunetti, Giulia Pianigiani, Michael C Gundry, et al.
MV140 Mucosal Vaccine Induces Targeted Immune Response for Enhanced Clearance of Uropathogenic E coli in Experimental Urinary Tract Infection, Paula Saz-Leal, Marianne Morris Ligon, Carmen María Diez-Rivero, et al.
Near-Infrared Spectroscopy Data for Foot Skin Oxygen Saturation in Healthy Subjects, Mehmet A Suludere, Arthur Tarricone, Bijan Najafi, et al.
Neural Circuits Expressing the Serotonin 2C Receptor Regulate Memory in Mice and Humans, Hesong Liu, Yang He, Hailan Liu, et al.
Neuronal Ablation of GHSR Mitigates Diet-Induced Depression and Memory Impairment via AMPK-Autophagy Signaling-Mediated Inflammation, Hongying Wang, Zheng Shen, Chia-Shan Wu, et al.
Novel Avenues of Tau Research, Claire E Sexton, Gal Bitan, Kathryn R Bowles, et al.
Offloading and Adherence Through Technological Advancements: Modern Approaches for Better Foot Care in Diabetes, Sicco A Bus, Neil D Reeves, David G Armstrong, et al.
Parkinson's Disease and Other Alzheimer's Disease and Related Dementia Pathologies and the Progression of Parkinsonism in Older Adults, Aron S Buchman, Lei Yu, Shahram Oveisgharan, et al.
Preeclampsia in the Context of COVID-19: Mechanisms, Pathophysiology, and Clinical Outcomes, Guilherme M Nobrega, Brittany R Jones, Indira U Mysorekar, et al.
Quantitative Biomechanical Analysis in Validating a Video-Based Model To Remotely Assess Physical Frailty: A Potential Solution to Telehealth and Globalized Remote-Patient Monitoring, Mohammad Dehghan Rouzi, Myeounggon Lee, Jaewon Beom, et al.
Research Participants' Perspectives on Precision Diagnostics for Alzheimer's Disease, Hadley Stevens Smith, Jill O Robinson, Ariel Levchenko, et al.
SIRT1 Safeguards Adipogenic Differentiation by Orchestrating Anti-Oxidative Responses and Suppressing Cellular Senescence, An Yu, Ruofan Yu, Haiying Liu, et al.
SOD1 Is a Synthetic-Lethal Target in PPM1D-Mutant Leukemia Cells, Linda Zhang, Joanne I Hsu, Etienne D Braekeleer, et al.
Targeting Histone Deacetylase in Cardiac Diseases, Jiao Lu, Sichong Qian, and Zheng Sun
Tau Is Required for Glial Lipid Droplet Formation and Resistance to Neuronal Oxidative Stress, Lindsey D Goodman, Isha Ralhan, Xin Li, et al.
TFEB Safeguards Trophoblast Syncytialization in Humans and Mice, Wanshan Zheng, Yue Zhang, Peiqun Xu, et al.