The HCOA was formed in 1988 by the generosity of the late ">Roy M. and Phyllis Gough Huffington, Houston philanthropists who foresaw the need for an academic entity devoted to studying aging, providing care for older people, and teaching future health professionals and researchers about geriatrics and gerontology.
The Roy M. and Phyllis Gough Huffington Center on Aging spearheads breakthrough research and is committed to translating basic research discoveries into applications that promote healthy aging and combat age-associated disorders. The faculty, along with their research staff and trainees, utilize diverse model systems and multidisciplinary approaches to address questions that are of crucial importance to the biology, pathophysiology and diseases of aging. The major research topics include lifespan and health span studies, aging of the endocrine, vasculature, and central nervous systems, cancer, and neurodegenerative diseases, in particular Alzheimer’s disease..
Submissions from 2025
Association of Area Deprivation Index With Perinatal and COVID-19 Outcomes During the Early Pandemic: A Secondary Analysis of a Prospective Cohort Study, Abigail Bell, Megan Foeller, Candice Woolfolk, et al.
Clonal Dynamics and Somatic Evolution of Haematopoiesis in Mouse, Chiraag D Kapadia, Nicholas Williams, Kevin J Dawson, et al.
DeepMVP: Deep Learning Models Trained on High-Quality Data Accurately Predict PTM Sites and Variant-Induced Alterations, Bo Wen, Chenwei Wang, Kai Li, et al.
Development and Implementation of a Personal Virtual Assistant for Patient Engagement and Communication in Postsurgical Cancer Care: Feasibility Cohort Study, Miguel Bargas-Ochoa, Alejandro Zulbaran-Rojas, M G Finco, et al.
DNMT3A Regulates Murine Megakaryocyte-Biased Hematopoietic Stem Cell Fate Decisions, Sarah M Waldvogel, Virginia Camacho, Dandan Fan, et al.
Enzyme-Independent Functions of HDAC3 in the Adult Hear, Sichong Qian, Chen Zhang, Wenbo Li, et al.
FlyPhoneDB2: A Computational Framework for Analyzing Cell-Cell Communication in Drosophila scRNA-Seq Data Integrating AlphaFold-Multimer Predictions, Mujeeb Qadiri, Ying Liu, Ah-Ram Kim, et al.
Haploinsufficiency of ITSN1 Is Associated With a Substantial Increased Risk of Parkinson’s Disease, Thomas P Spargo, Chloe F Sands, Isabella R Juan, et al.
Histone H3 Cysteine 110 Enhances Iron Metabolism and Modulates Replicative Life Span In Saccharomyces cerevisiae, Chen Cheng, Brenna S McCauley, Nedas Matulionis, et al.
Inhibition of Soluble Epoxide Hydrolase Confers Neuroprotection and Restores Microglial Homeostasis in a Tauopathy Mouse Model, Shuo Wang, Chuangye Qi, Chetan Rajpurohit, et al.
Integrative Spatial Omics Reveals Distinct Tumor-Promoting Multicellular Niches and Immunosuppressive Mechanisms in Black American and White American Patients With TNBC, Qian Zhu, Akhila Balasubramanian, Jaya Ruth Asirvatham, et al.
Lessons in Longevity From Blood Stem Cells Under Protein Stress, André Catic
Longitudinal Multi-Omics in Alpha-Synuclein Drosophila Model Discriminates Disease- From Age-Associated Pathologies in Parkinson’s Disease, Justin Moore, Timothy Wu, Justin Dhindsa, et al.
Modeling Functional Connectivity With Learning and Memory in a Mouse Model of Alzheimer’s Disease, Lindsay Fadel, Elizabeth Hipskind, Steen E Pedersen, et al.
Multi-Omics Delineate Growth Factor Network Underlying Exercise Effects in an Alzheimer’s Mouse Model, Xin Li, Chaozhong Liu, Wenbo Li, et al.
Muscle Rev-Erb Controls Time-Dependent Adaptations to Chronic Exercise in Mice, Jidong Liu, Fang Xiao, Abhinav Choubey, et al.
NKAPL Facilitates Transcription Pause-Release and Bridges Elongation to Initiation During Meiosis Exit, Zhenlong Kang, Chen Xu, Shuai Lu, et al.
Prolonged Exposure to Food Odors Suppresses Feeding via an Olfactory Bulb-to-Hypothalamus Circuit, Yao Liu, Hailan Liu, Huey-Xian Kelly Wong, et al.
Quantitative Profiling pH Heterogeneity of Acidic Endolysosomal Compartments Using Fluorescence Lifetime Imaging Microscopy, Dinghuan Deng, Youchen Guan, Ayse Sena Mutlu, et al.
Reduction of Neuronal Activity Mediated by Blood-Vessel Regression in the Adult Brain, Xiaofei Gao, Xing-Jun Chen, Meng Ye, et al.
Rewired m6A of Promoter Antisense RNAs in Alzheimer’s Disease Regulates Neuronal Genes in 3D Nucleome, Benxia Hu, Yuqiang Shi, Feng Xiong, et al.
Rewired m6A of Promoter Antisense RNAs in Alzheimer’s Disease Regulates Neuronal Genes in 3D Nucleome, Benxia Hu, Yuqiang Shi, Feng Xiong, et al.
Robotic First Rib Resection With Adjuvant Endovascular Therapy for Chronic Paget-Schroetter Syndrome, Alejandro Zulbaran-Rojas, Miguel Montero-Baker, Nihanth Palivela, et al.
SmartBoot: Real-Time Monitoring of Patient Activity via Remote Edge Computing Technologies, Gozde Cay, Myeounggon Lee, David G Armstrong, et al.
Surgical Removal of Implanted Microchips To Correct MRI Susceptibility Artifacts in Mice, Elizabeth Hipskind, Nicole Hernandez, Sydney Fox, et al.