The HCOA was formed in 1988 by the generosity of the late ">Roy M. and Phyllis Gough Huffington, Houston philanthropists who foresaw the need for an academic entity devoted to studying aging, providing care for older people, and teaching future health professionals and researchers about geriatrics and gerontology.
The Roy M. and Phyllis Gough Huffington Center on Aging spearheads breakthrough research and is committed to translating basic research discoveries into applications that promote healthy aging and combat age-associated disorders. The faculty, along with their research staff and trainees, utilize diverse model systems and multidisciplinary approaches to address questions that are of crucial importance to the biology, pathophysiology and diseases of aging. The major research topics include lifespan and health span studies, aging of the endocrine, vasculature, and central nervous systems, cancer, and neurodegenerative diseases, in particular Alzheimer’s disease..
Submissions from 2023
Increased SIRT3 Combined With PARP Inhibition Rescues Motor Function of SBMA Mice, David R Garcia Castro, Joseph R Mazuk, Erin M Heine, et al.
Integration of Transcriptome-Wide Association Study With Neuronal Dysfunction Assays Provides Functional Genomics Evidence for Parkinson’s Disease Genes, Jiayang Li, Bismark Kojo Amoh, Emma McCormick, et al.
In Vivo Gene Delivery into Mouse Mammary Epithelial Cells Through Mammary Intraductal Injection, Wen Bu and Yi Li
Loss of Stearoyl-CoA Desaturase 2 Disrupts Inflammatory Response in Macrophages, Joseph B Lin, Amy Mora, Tzu Jui Wang, et al.
Machine Learning-Based Aggression Detection in Children with ADHD Using Sensor-Based Physical Activity Monitoring, Catherine Park, Mohammad Dehghan Rouzi, Md Moin Uddin Atique, et al.
Mammalian Aging Driven by Transcription Going Awry, Brenna S McCauley and Weiwei Dang
Mechanical and Contact Characteristics of Foam Materials Within Wound Dressings: Theoretical and Practical Considerations in Treatment, Amit Gefen, Paulo Alves, Dimitri Beeckman, et al.
Modulation of the Proteostasis Network Promotes Tumor Resistance to Oncogenic KRAS Inhibitors, Xiangdong Lv, Xuan Lu, Jin Cao, et al.
Nad+ Rescues Aging-Induced Blood-Brain Barrier Damage via the CX43-PARP1 Axis, Rui Zhan, Xia Meng, Dongping Tian, et al.
Nicotinic Acetylcholine Receptor Signaling Maintains Epithelial Barrier Integrity, Nadja S Katheder, Kristen C Browder, Diana Chang, et al.
Oleoylethanolamide Facilitates PPARα and Tfeb Signaling and Attenuates Aβ Pathology in a Mouse Model of Alzheimer’s Disease, Michele M Comerota, Manasee Gedam, Wen Xiong, et al.
Optimizing Tissue Oxygenation in Reduction Mammoplasty: The Role of Continuous Diffusion of Oxygen: A Feasibility Pilot Randomized Controlled Trial, Alejandro Zulbaran-Rojas, Rasha O Bara, Myeounggon Lee, et al.
Outersphere Approach to Increasing the Persistance of Oxygen-Sensitive Europium(II)-Containing Contrast Agents for Magnetic Resonance Imaging with Perfluorocarbon Nanoemulsions toward Imaging of Hypoxia, Jacob C Lutter, Andrea L Batchev, Caitlyn J Ortiz, et al.
Pharmacological Management of Disease by Overcoming Structural Adversity, Richard N Sifers
Proteogenomic Insights Suggest Druggable Pathways in Endometrial Carcinoma, Yongchao Dou, Lizabeth Katsnelson, Marina A Gritsenko, et al.
Reprogramming of Cis-Regulatory Networks During Skeletal Muscle Atrophy in Male Mice, Hongchun Lin, Hui Peng, Yuxiang Sun, et al.
Role of Biomarkers (sFlt-1/PlGF) in Cases of COVID-19 for Distinguishing Preeclampsia and Guiding Clinical Management, Guilherme M Nobrega, Jose P Guida, Juliana M Novaes, et al.
Sex Differences in Paternal Arsenic-Induced Intergenerational Metabolic Effects Are Mediated by Estrogen, Yanfeng Xue, Yingyun Gong, Xin Li, et al.
Short-term PI3K Inhibition Prevents Breast Cancer in Preclinical Models, Amy T Ku, Adelaide I J Young, Ahmed Atef Ibrahim, et al.
Smart Offloading Boot System for Remote Patient Monitoring: Toward Adherence Reinforcement and Proper Physical Activity Prescription for Diabetic Foot Ulcer Patients, Catherine Park, Ramkinker Mishra, Davide Vigano, et al.
SRCAP Mutations Drive Clonal Hematopoiesis Through Epigenetic and DNA Repair Dysregulation, Chun-Wei Chen, Linda Zhang, Ravi Dutta, et al.
STAT5 Confers Lactogenic Properties In Breast Tumorigenesis and Restricts Metastatic Potential, Richard S Lampitt, Stephen Fletcher, Matthew Cole, et al.
Structural Basis of Impaired Disaggregase Function in the Oxidation-Sensitive SKD3 Mutant Causing 3-Methylglutaconic Aciduria, Jose J Gorbea Colón, Leon Palao, Shin-Fu Chen, et al.
Structural Foundations of Potassium Selectivity in Channelrhodopsins, Sukyeong Lee, Sang Bum Lee, Nuri Sung, et al.
Structure, Function, and Molecular Landscapes of the Aging Retina, Jeffrey D Zhu, Sharma Pooja Tarachand, Qudrat Abdulwahab, et al.