The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2023
Plasma Metabolites associated With Cognitive Function across Race/Ethnicities affirming the Importance of Healthy Nutrition, Einat Granot-Hershkovitz, Shan He, Jan Bressler, et al.
Polygenic Genetic Variation Affecting Antibody Formation Underlies Hypertensive Renal Injury in the Stroke-Prone Spontaneously Hypertensive Rat, Isha S Dhande, Yaming Zhu, Aniket S Joshi, et al.
Premature Senescence and Cardiovascular Disease Following Cancer Treatments: Mechanistic Insights, Ashita Jain, Diego Casanova, Alejandra Valdivia Padilla, et al.
Prospective, Early Longitudinal Assessment of Lymphedema-Related Quality of Life Among Patients With Locally Advanced Breast Cancer: The Foundation for Building a Patient-Centered Screening Program, Anusha Gandhi, Tianlin Xu, Sarah M DeSnyder, et al.
Protein Advanced Glycation End Products and Their Implications in Pancreatic Cancer, Lakmini Senavirathna, Sheng Pan, and Ru Chen
Protein SUMOylation and Phase Separation: Partners in Stress?, Xiaodong Cheng
Proteomic Analysis Identifies Circulating Proteins Associated With Plasma Amyloid-β and Incident Dementia, Adrienne Tin, Kevin J Sullivan, Keenan A Walker, et al.
Proteomics Analysis of Plasma From Middle-Aged Adults Identifies Protein Markers of Dementia Risk in Later Life, Keenan A Walker, Jingsha Chen, Liu Shi, et al.
Rare Variants in Long Non-Coding RNAs Are Associated With Blood Lipid Levels in the TOPMed Whole-Genome Sequencing Study, Yuxuan Wang, Margaret Sunitha Selvaraj, Xihao Li, et al.
Risk Factors for Blunt Cerebrovascular Injury in the Pediatric Patient: A Systematic Review, Madison Schulz, Veronica Weihing, Manish N Shah, et al.
SARS-CoV-2 Restructures Host Chromatin Architecture, Ruoyu Wang, Joo-Hyung Lee, Jieun Kim, et al.
Stress Responses and Ammonia Nitrogen Removal Efficiency of Oocystis lacustris in Saline Ammonium-Contaminated Wastewater Treatment, Linda Ewing-Cobbs, Christina V Danna, Tammy D Tolar, et al.
Structural Basis for Transcription Factor ZBTB7A Recognition of DNA and Effects of ZBTB7A Somatic Mutations That Occur in Human Acute Myeloid Leukemia, Ren Ren, John R Horton, Qin Chen, et al.
Structures of CTCF-DNA Complexes Including All 11 Zinc Fingers, Jie Yang, John R Horton, Bin Liu, et al.
Substrate Derived Sequences Act As Subsite-Blocking Motifs in Protease Inhibitory Antibodies, Hyunjun Choe, Tara Antee, and Xin Ge
Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence, Jujun Zhou, John R Horton, Martina Menna, et al.
TET2 Modulates Spatial Relocalization of Heterochromatin in Aged Hematopoietic Stem and Progenitor Cells, Tingting Hong, Jia Li, Lei Guo, et al.
The Assembled Genome of the Stroke-Prone Spontaneously Hypertensive Rat, Theodore S Kalbfleisch, Nahla A Hussien AbouEl Ela, Kai Li, et al.
The Genetic Determinants of Recurrent Somatic Mutations in 43,693 Blood Genomes, Joshua S Weinstock, Cecelia A Laurie, Jai G Broome, et al.
The Genomic Landscape of Familial Glioma, Dong-Joo Choi, Georgina Armstrong, Brittney Lozzi, et al.
The Melanocortin Action Is Biased Toward Protection From Weight Loss in Mice, Hongli Li, Yuanzhong Xu, Yanyan Jiang, et al.
Transcriptome-Wide Profiling of Acute Stress Induced Changes in Ribosome Occupancy Level Using External Standards, Annie W Shieh, Sandeep K Bansal, Zhen Zuo, et al.
Type 2 Diabetes Modifies the Association of Cad Genomic Risk Variants With Subclinical Atherosclerosis, Natalie R Hasbani, Kenneth E Westerman, Soo Heon Kwak, et al.
Upregulation of Epac1 Promotes Pericyte Loss by Inducing Mitochondrial Fission, Reactive Oxygen Species Production, and Apoptosis, Wenli Yang, Fan Xia, Fang Mei, et al.
Vaccination With a Replication-Defective Cytomegalovirus Vaccine Elicits a Glycoprotein B-Specific Monoclonal Antibody Repertoire Distinct From Natural Infection, Sarah M Valencia, Eric Rochat, Melissa J Harnois, et al.