The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2023
RagD Auto-Activating Mutations Impair MIT/TFE Activity in Kidney Tubulopathy and Cardiomyopathy Syndrome, Irene Sambri, Marco Ferniani, Giulia Campostrini, et al.
Rare Variants in Long Non-Coding RNAs Are Associated With Blood Lipid Levels in the TOPMed Whole-Genome Sequencing Study, Yuxuan Wang, Margaret Sunitha Selvaraj, Xihao Li, et al.
RBFOX2 Regulated EYA3 Isoforms Partner With SIX4 or ZBTB1 To Control Transcription During Myogenesis, Hannah J Wiedner, R Eric Blue, Matheus Sadovsky, et al.
SARS-CoV-2 Restructures Host Chromatin Architecture, Ruoyu Wang, Joo-Hyung Lee, Jieun Kim, et al.
Stress Responses and Ammonia Nitrogen Removal Efficiency of Oocystis lacustris in Saline Ammonium-Contaminated Wastewater Treatment, Linda Ewing-Cobbs, Christina V Danna, Tammy D Tolar, et al.
Structural Basis for Transcription Factor ZBTB7A Recognition of DNA and Effects of ZBTB7A Somatic Mutations That Occur in Human Acute Myeloid Leukemia, Ren Ren, John R Horton, Qin Chen, et al.
Structures of CTCF-DNA Complexes Including All 11 Zinc Fingers, Jie Yang, John R Horton, Bin Liu, et al.
Substrate Derived Sequences Act As Subsite-Blocking Motifs in Protease Inhibitory Antibodies, Hyunjun Choe, Tara Antee, and Xin Ge
Synaptic Scaling of Corticostriatal Circuits Underlies Hyperactivity in Gaba Transporter-1 Deficient Mice, Yan-Jiao Wu, Xin Yi, Xue Gu, et al.
Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence, Jujun Zhou, John R Horton, Martina Menna, et al.
TET2 Modulates Spatial Relocalization of Heterochromatin in Aged Hematopoietic Stem and Progenitor Cells, Tingting Hong, Jia Li, Lei Guo, et al.
The Assembled Genome of the Stroke-Prone Spontaneously Hypertensive Rat, Theodore S Kalbfleisch, Nahla A Hussien AbouEl Ela, Kai Li, et al.
The Genetic Determinants of Recurrent Somatic Mutations in 43,693 Blood Genomes, Joshua S Weinstock, Cecelia A Laurie, Jai G Broome, et al.
The Genomic Landscape of Familial Glioma, Dong-Joo Choi, Georgina Armstrong, Brittney Lozzi, et al.
The Melanocortin Action Is Biased Toward Protection From Weight Loss in Mice, Hongli Li, Yuanzhong Xu, Yanyan Jiang, et al.
The Transcription Factor Irf4 Determines The Anti-Tumor Immunity of CD8+ T Cells, Hui Yan, Yulin Dai, Xiaolong Zhang, et al.
Transcriptome, Proteome, and Protein Synthesis Within the Intracellular Cytomatrix, Tattym E Shaiken, Sandra L Grimm, Mohamad Siam, et al.
Transcriptome-Wide Profiling of Acute Stress Induced Changes in Ribosome Occupancy Level Using External Standards, Annie W Shieh, Sandeep K Bansal, Zhen Zuo, et al.
Two Structurally Defined Aβ Polymorphs Promote Different Pathological Changes in Susceptible Mice, Ruben Gomez-Gutierrez, Ujjayini Ghosh, Wai-Ming Yau, et al.
Type 2 Diabetes Modifies the Association of Cad Genomic Risk Variants With Subclinical Atherosclerosis, Natalie R Hasbani, Kenneth E Westerman, Soo Heon Kwak, et al.
Upregulation of Epac1 Promotes Pericyte Loss by Inducing Mitochondrial Fission, Reactive Oxygen Species Production, and Apoptosis, Wenli Yang, Fan Xia, Fang Mei, et al.
Vaccination With a Replication-Defective Cytomegalovirus Vaccine Elicits a Glycoprotein B-Specific Monoclonal Antibody Repertoire Distinct From Natural Infection, Sarah M Valencia, Eric Rochat, Melissa J Harnois, et al.
Validation and Characterization of A Novel Blood–Brain Barrier Platform For Investigating Traumatic Brain Injury, Christopher T Bolden, Max A Skibber, Scott D Olson, et al.
Vitamin B2 Enables Regulation of Fasting Glucose Availability, Peter M Masschelin, Pradip Saha, Scott A Ochsner, et al.
Whole-Exome Sequencing Study Identifies Four Novel Gene Loci Associated With Diabetic Kidney Disease, Yang Pan, Xiao Sun, Xuenan Mi, et al.