The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2023
Disease Modeling and Gene Correction of LGMDR21 iPSCs Elucidates the Role of POGLUT1 in Skeletal Muscle Maintenance, Regeneration, and the Satellite Cell Niche, Jose L Ortiz-Vitali, Jianbo Wu, Nasa Xu, et al.
DNA Methylation Analysis Is Used To Identify Novel Genetic Loci Associated With Circulating Fibrinogen Levels in Blood, Julie Hahn, Jan Bressler, Arce Domingo-Relloso, et al.
Dural Sinus Narrowing In Patients With Spontaneous Anterior Skull Base Cerebrospinal Fluid Leak, Karim W Asi, Brian H Cameron, Elliot R Friedman, et al.
Endotrophin Neutralization Through Targeted Antibody Treatment Protects From Renal Fibrosis in a Podocyte Ablation Model, Yu A An, Wei Xiong, Shiuhwei Chen, et al.
Energy Intake at the Intersection of the Clock and Ageing, Kristin Eckel-Mahan
Epigenome-Wide Association Study Reveals CpG Sites Associated with Thyroid Function and Regulatory Effects on KLF9, Antoine Weihs, Layal Chaker, Tiphaine C Martin, et al.
Estimating Heritability Explained By Local ancestry and Evaluating Stratification Bias in admixture Mapping From Summary Statistics, Tsz Fung Chan, Xinyue Rui, David V Conti, et al.
Evaluating the Use of Blood Pressure Polygenic Risk Scores Across Race/Ethnic Background Groups, Nuzulul Kurniansyah, Matthew O Goodman, Alyna T Khan, et al.
Expansion of the Genotypic and Phenotypic Spectrum of CTCF-Related Disorder Guides Clinical Management: 43 New Subjects and a Comprehensive Literature Review, Hannah Gabriela Valverde de Morales, Hsiao-Lin V Wang, Kathryn Garber, et al.
Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives, Kai Sun, Xin Li, and Philipp E Scherer
Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging, Brian J Engel, Vincenzo Paolillo, Md Nasir Uddin, et al.
Gene-Educational Attainment Interactions in a Multi-population Genome-Wide Meta-Analysis Identify Novel Lipid Loci, Lisa de Las Fuentes, Karen L Schwander, Michael R Brown, et al.
Genetic Associations Between Sleep Traits and Cognitive Ageing Outcomes in the Hispanic Community Health Study/Study of Latinos, Yuan Zhang, Michael Elgart, Einat Granot-Hershkovitz, et al.
Genetic Inactivation of β-Catenin Is Salubrious, Whereas Its Activation Is Deleterious in Desmoplakin Cardiomyopathy, Melis Olcum, Siyang Fan, Leila Rouhi, et al.
Genetic Loci of Beta-Aminoisobutyric Acid Are Associated With Aging-Related Mild Cognitive Impairment, Einat Granot-Hershkovitz, Brian Spitzer, Yunju Yang, et al.
Glycolysis Regulates Kras Plasma Membrane Localization and Function Through Defined Glycosphingolipids, Junchen Liu, Ransome van der Hoeven, Walaa E Kattan, et al.
G Protein-Coupled Receptor-Targeting Antibody-Drug Conjugates: Current Status and Future Directions, Peyton High and Kendra S Carmon
GSK-3484862 Targets DNMT1 for Degradation in Cells, Qin Chen, Bigang Liu, Yang Zeng, et al.
High-Fidelity Large-Diversity Monoclonal Mammalian Cell Libraries by Cell Cycle Arrested Recombinase-Mediated Cassette Exchange, Chuan Chen, Zening Wang, Minhyo Kang, et al.
HNF4α Isoforms Regulate the Circadian Balance Between Carbohydrate and Lipid Metabolism in the Liver, Jonathan R Deans, Poonamjot Deol, Nina Titova, et al.
Hyperleptinemia Contributes to Antipsychotic Drug-Associated Obesity and Metabolic Disorders, Shangang Zhao, Qian Lin, Wei Xiong, et al.
Identification of Circulating Proteins associated With General Cognitive Function among Middle-Aged and Older Adults, Adrienne Tin, Alison E Fohner, Qiong Yang, et al.
Imaging Peripheral Lymphatic Dysfunction in Chronic Conditions, Eva M Sevick-Muraca, Caroline E Fife, and John C Rasmussen
Impact of Transfused Citrate on Pathophysiology in Massive Transfusion, Jacob B Schriner, J Michael Van Gent, M Adam Meledeo, et al.
Induction of Astrocytic Slc22a3 Regulates Sensory Processing Through Histone Serotonylation, Debosmita Sardar, Yi-Ting Cheng, Junsung Woo, et al.