The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2023
G Protein-Coupled Receptor-Targeting Antibody-Drug Conjugates: Current Status and Future Directions, Peyton High and Kendra S Carmon
GSK-3484862 Targets DNMT1 for Degradation in Cells, Qin Chen, Bigang Liu, Yang Zeng, et al.
High-Fidelity Large-Diversity Monoclonal Mammalian Cell Libraries by Cell Cycle Arrested Recombinase-Mediated Cassette Exchange, Chuan Chen, Zening Wang, Minhyo Kang, et al.
HIV-1 Vpu Protein Forms Stable Oligomers in Aqueous Solution via Its Transmembrane Domain Self-Association, Saman Majeed, Lan Dang, Md Majharul Islam, et al.
HNF4α Isoforms Regulate the Circadian Balance Between Carbohydrate and Lipid Metabolism in the Liver, Jonathan R Deans, Poonamjot Deol, Nina Titova, et al.
Hyperleptinemia Contributes to Antipsychotic Drug-Associated Obesity and Metabolic Disorders, Shangang Zhao, Qian Lin, Wei Xiong, et al.
Identification of Circulating Proteins associated With General Cognitive Function among Middle-Aged and Older Adults, Adrienne Tin, Alison E Fohner, Qiong Yang, et al.
Imaging Peripheral Lymphatic Dysfunction in Chronic Conditions, Eva M Sevick-Muraca, Caroline E Fife, and John C Rasmussen
Impact of Transfused Citrate on Pathophysiology in Massive Transfusion, Jacob B Schriner, J Michael Van Gent, M Adam Meledeo, et al.
Increased SIRT3 Combined With Parp Inhibition Rescues Motor Function of Sbma Mice, David R Garcia Castro, Joseph R Mazuk, Erin M Heine, et al.
Induction of Astrocytic Slc22a3 Regulates Sensory Processing Through Histone Serotonylation, Debosmita Sardar, Yi-Ting Cheng, Junsung Woo, et al.
Influence of Trpm4 Rs8104571 Genotype On Intracranial Pressure and Outcomes In African Americans With Traumatic Brain Injury, Joseph D Krocker, Madeline E Cotton, Jacob B Schriner, et al.
Innate Immune Activation and White Matter Injury in a Rat Model of Neonatal Intraventricular Hemorrhage Are Dependent on Developmental Stage, Miriam Zamorano, Scott D Olson, Candice Haase, et al.
Innovations In Cell Therapy In Pediatric Diseases: A Narrative Review, Razan El Sayed, Karan Michael Shankar, Atharwa Rajan Mankame, et al.
Interaction Analysis of Ancestry-Enriched Variants With Apoe-ɛ4 on Mci in the Study of Latinos-Investigation of Neurocognitive Aging, Einat Granot-Hershkovitz, Rui Xia, Yunju Yang, et al.
Interfering With Lipid Metabolism Through Targeting CES1 Sensitizes Hepatocellular Carcinoma for Chemotherapy, Gang Li, Xin Li, Iqbal Mahmud, et al.
Iron Overload Induces Cerebral Endothelial Senescence in Aged Mice and in Primary Culture in a Sex-Dependent Manner, Brian Noh, Maria Pilar Blasco-Conesa, Syed Mushfiqur Rahman, et al.
Isolation of Human Cutaneous Immune Cells for Single-Cell RNA Sequencing, Ashley A Hailer, David Wu, Abdullah El Kurdi, et al.
Lateral Septum as a Melanocortin Downstream Site in Obesity Development, Yuanzhong Xu, Zhiying Jiang, Hongli Li, et al.
Leucine-Rich Alpha-2-Glycoprotein 1 is a Systemic Biomarker of Early Brain Injury and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage, Jude P J Savarraj, Devin W McBride, Eunsu Park, et al.
LGR4 and LGR5 Form Distinct Homodimers That Only LGR4 Complexes With RNF43/ZNRF3 To Provide High Affinity Binding of R-Spondin Ligands, Yukimatsu Toh, Ling Wu, Soohyun Park, et al.
Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells, Tressie A Posey, Joan Jacob, Ashlyn Parkhurst, et al.
Major Differences In Transcriptional Alterations In Dorsal Root Ganglia Between Spinal Cord Injury and Peripheral Neuropathic Pain Models, Raquel Cuevas-Diaz Duran, Yong Li, Anibal Garza Carbajal, et al.
Molecular Basis of Retinal Remodeling in a Zebrafish Model of Retinitis Pigmentosa, Abirami Santhanam, Eyad Shihabeddin, Haichao Wei, et al.
Mosaic Chromosomal Alterations in Blood Across Ancestries Using Whole-Genome Sequencing, Yasminka A Jakubek, Ying Zhou, Adrienne Stilp, et al.