The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2024
TREX2 Deficiency Suppresses Spontaneous and Genotoxin-Associated Mutagenesis, Teresa Marple, Mi Young Son, Xiaodong Cheng, et al.
TRIM44, a Novel Prognostic Marker, Supports the Survival of Proteasome-Resistant Multiple Myeloma Cells, Trung Vu, Yuqin Wang, Annaliese Fowler, et al.
TRIM44 Enhances Autophagy via SQSTM1 Oligomerization in Response to Oxidative Stress, Yuqin Wang, Lin Lyu, Trung Vu, et al.
Updated Understanding of the Protein-DNA Recognition Code Used by C2H2 Zinc Finger Proteins, Xing Zhang, Robert M Blumenthal, and Xiaodong Cheng
Validation of Human Telomere Length Multi-Ancestry Meta-Analysis Association Signals Identifies POP5 and KBTBD6 as Human Telomere Length Regulation Genes, Rebecca Keener, Surya B Chhetri, Carla J Connelly, et al.
Whole-Genome Analysis of Plasma Fibrinogen Reveals Population-Differentiated Genetic Regulators With Putative Liver Roles, Jennifer E Huffman, Jayna Nicholas, Julie Hahn, et al.
Whole Genome Sequencing Based Analysis of Inflammation Biomarkers in the Trans-omics for Precision Medicine (TOPMed) Consortium, Min-Zhi Jiang, Sheila M Gaynor, Xihao Li, et al.
Submissions from 2023
Aberrant Activation of TCL1A Promotes Stem Cell Expansion in Clonal Haematopoiesis, Joshua S Weinstock, Jayakrishnan Gopakumar, Bala Bharathi Burugula, et al.
A Complete Methyl-Lysine Binding Aromatic Cage Constructed by Two Domains of PHF2, John R Horton, Jujun Zhou, Qin Chen, et al.
A Decade of Blood-Brain Barrier Permeability Assays: Revisiting Old Traumatic Brain Injury Rat Data For New Insights and Experimental Design, Chris T Bolden, Scott D Olson, and Charles S Cox
A Distinct Human Cell Type Expressing MHCII and RORγt With Dual Characteristics of Dendritic Cells and Type 3 Innate Lymphoid Cells, Alina Ulezko Antonova, Silvia Lonardi, Matilde Monti, et al.
Adult Presentation of Congenital Tracheooesophageal Fistula Treated As Asthma and Recurrent Respiratory Infections, Natalie A Drucker and Charles S Cox
Advances in the Treatment of Invasive Fungal Disease, Zhuan Zhang, Gerald F Bills, and Zhiqiang An
AgRP Neurons Are Not Indispensable for Body Weight Maintenance in Adult Mice, Jing Cai, Jing Chen, Joshua Ortiz-Guzman, et al.
A Highly Selective Humanized DDR1 Mab Reverses Immune Exclusion by Disrupting Collagen Fiber Alignment in Breast Cancer, Junquan Liu, Huai-Chin Chiang, Wei Xiong, et al.
A Human Mitofusin 2 Mutation Can Cause Mitophagic Cardiomyopathy, Antonietta Franco, Jiajia Li, Daniel P Kelly, et al.
Allosteric Autoregulation of DNA Binding via a DNA-Mimicking Protein Domain: A Biophysical Study of ZNF410-DNA Interaction Using Small Angle X-Ray Scattering, Gundeep Kaur, Ren Ren, Michal Hammel, et al.
A Mendelian Randomization Study of Genetic Liability to Post-traumatic Stress Disorder and Risk of Ischemic Stroke, Opeyemi Soremekun, Clarisse Musanabaganwa, Annette Uwineza, et al.
An ACE2 Decamer Viral Trap as a Durable Intervention Solution for Current and Future SARS-COV, Hailong Guo, Bomsoo Cho, Paul R Hinton, et al.
An Antibody-Drug Conjugate Targeting Gpr56 Demonstrates Efficacy In Preclinical Models of Colorectal Cancer, Joan Jacob, Liezl E Francisco, Treena Chatterjee, et al.
An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis, Jun-Ichi Abe, Masaki Imanishi, Shengyu Li, et al.
Anoctamin 4 Channel Currents Activate Glucose-Inhibited Neurons in the Mouse Ventromedial Hypothalamus During Hypoglycemia, Longlong Tu, Jonathan C Bean, Yang He, et al.
A Novel GRK3-HDAC2 Regulatory Pathway Is a Key Direct Link Between Neuroendocrine Differentiation and Angiogenesis in Prostate Cancer Progression, Samira Naderinezhad, Guoliang Zhang, Zheng Wang, et al.
A Novel Humanized Chi3L1 Blocking Antibody Attenuates Acetaminophen-Induced Liver Injury In Mice, Leike Li, Yankai Wen, Daniel Wrapp, et al.
Anthocyanins: Molecular Aspects on Their Neuroprotective Activity, César A Zaa, Álvaro J Marcelo, Zhiqiang An, et al.