The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2023
Antibody Therapies For The Treatment of Acute Myeloid Leukemia: Exploring Current and Emerging Therapeutic Targets, Joshua W Morse, Margarita Rios, John Ye, et al.
A Polycistronic System for Multiplexed and Precalibrated Expression of Multigene Pathways in Fungi, Qun Yue, Jie Meng, Yue Qiu, et al.
A Polygenic Risk Score for Alzheimer’s Disease Constructed Using Apoe-Region Variants Has Stronger Association Than Apoe Alleles With Mild Cognitive Impairment in Hispanic/Latino Adults in the US, Tamar Sofer, Nuzulul Kurniansyah, Einat Granot-Hershkovitz, et al.
A Potent and Broad Neutralization of SARS-Cov-2 Variants of Concern by DARpins, Vikas Chonira, Young D Kwon, Jason Gorman, et al.
Association Between Whole Blood-Derived Mitochondrial Dna Copy Number, Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk, Xue Liu, Xianbang Sun, Yuankai Zhang, et al.
Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function: A Meta-Analysis of Community-Based Cohorts, Yuankai Zhang, Xue Liu, Kerri L Wiggins, et al.
Association of Rare Protein-Truncating DNA Variants in APOB or PCSK9 With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease, Jacqueline S Dron, Aniruddh P Patel, Yiyi Zhang, et al.
Author Correction: The Power of Genetic Diversity in Genome-Wide Association Studies of Lipids, Sarah E Graham, Shoa L Clarke, Kuan-Han H Wu, et al.
Biochemical and Structural Characterization of the First-Discovered Metazoan DNA Cytosine-N4 Methyltransferase From the Bdelloid Rotifer Adineta vaga, Jujun Zhou, John R Horton, Gundeep Kaur, et al.
Cardiac Muscle-Restricted Partial Loss of Nos1ap Expression Has Limited but Significant Impact on Electrocardiographic Features, Alexa Smith, Dallas Auer, Morgan Johnson, et al.
Causal Effects on Complex Traits Are Similar for Common Variants Across Segments of Different Continental Ancestries Within Admixed Individuals, Kangcheng Hou, Yi Ding, Ziqi Xu, et al.
Chromosome 10q2432 Variants Associate With Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study, Minghua Liu, Farid Khasiyev, Sanjeev Sariya, et al.
Circadian Rhythms As Modulators of Brain Health During Development and Throughout Aging, Rachel Van Drunen and Kristin Eckel-Mahan
Citrate Phosphate Dextrose Alters Coagulation Dynamics Ex Vivo, Jacob B Schriner, Atharwa Mankame, Scott D Olson, et al.
Clonal Hematopoiesis is Associated With Protection From Alzheimer's Disease, Hind Bouzid, Julia A Belk, Max Jan, et al.
Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk, Deirdre K Tobias, Alisa K Manning, Jennifer Wessel, et al.
Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile- Specific DNA Adenine Methyltransferase, Jujun Zhou, Youchao Deng, Iredia D Iyamu, et al.
Comprehensive Analysis of the Prognostic Significance of the TRIM Family in the Context of TP53 Mutations in Cancers, Trung Vu, Annaliese Fowler, and Nami McCarty
Consensus On The Ras Dimerization Hypothesis: Strong Evidence For Lipid-Mediated Clustering But Not For G-Domain-Mediated Interactions, Dhirendra K Simanshu, Mark R Philips, and John F Hancock
Co-Operative Roles of IL-4Rα and IL-13Rα1 in the Progression of Ovarian Carcinomas and the Survival of Ovarian Carcinoma Patients, Won Ku Choi, Usama Khamis Hussein, Asmaa Gamal Ahmed, et al.
Coronary Heart Disease and Ischemic Stroke Polygenic Risk Scores and atherosclerotic Cardiovascular Disease in a Diverse, Population-Based Cohort Study, Allison Bebo, Jamie A Jarmul, Mark J Pletcher, et al.
Dermatological Concerns for Women and Girls With Turner Syndrome, David Rodriguez-Buritica, Meaghan Mones, Siddharth K Prakash, et al.
Design and Development of a Clot Burst Pressure Device to Investigate Resuscitation Strategies, Atharwa R Mankame, Jacob B Schriner, Max A Skibber, et al.
Dexmedetomidine Alters The Inflammatory Profile of Rat Microglia In Vitro, Michael C Scott, Candice M Haase, Scott D Olson, et al.
Direct Modulators of K-Ras–Membrane Interactions, Johannes Morstein, Rebika Shrestha, Que N Van, et al.