The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2023
Leucine-Rich Alpha-2-Glycoprotein 1 is a Systemic Biomarker of Early Brain Injury and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage, Jude P J Savarraj, Devin W McBride, Eunsu Park, et al.
LGR4 and LGR5 Form Distinct Homodimers That Only LGR4 Complexes With RNF43/ZNRF3 To Provide High Affinity Binding of R-Spondin Ligands, Yukimatsu Toh, Ling Wu, Soohyun Park, et al.
Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells, Tressie A Posey, Joan Jacob, Ashlyn Parkhurst, et al.
Major Differences In Transcriptional Alterations In Dorsal Root Ganglia Between Spinal Cord Injury and Peripheral Neuropathic Pain Models, Raquel Cuevas-Diaz Duran, Yong Li, Anibal Garza Carbajal, et al.
Molecular Basis of Retinal Remodeling in a Zebrafish Model of Retinitis Pigmentosa, Abirami Santhanam, Eyad Shihabeddin, Haichao Wei, et al.
Mosaic Chromosomal Alterations in Blood Across Ancestries Using Whole-Genome Sequencing, Yasminka A Jakubek, Ying Zhou, Adrienne Stilp, et al.
Multi-Ancestry Genome-Wide Study Identifies Effector Genes and Druggable Pathways for Coronary Artery Calcification, Maryam Kavousi, Maxime M Bos, Hanna J Barnes, et al.
Multi-Center Validation of The Mcgovern Pediatric Blunt Cerebrovascular Injury Screening Score, Sidish S Venkataraman, Joseph P Herbert, Vijay M Ravindra, et al.
Neuroprotective Agents with Therapeutic Potential for COVID-19, César A Zaa, Clara Espitia, Karen L Reyes-Barrera, et al.
New Developments in Allergic Fungal Rhinosinusitis Pathophysiology and Treatment, Brian H Cameron and Amber U Luong
Otolaryngology Consultations For COVID-19 Patients: A Retrospective Cohort Study of Indications, Interventions, and Considerations, Kunal R Shetty, Brady J Anderson, Jumah G Ahmad, et al.
Overcoming Adaptive Resistance to Anti-vegf Therapy by Targeting CD5L, Christopher J LaFargue, Paola Amero, Kyunghee Noh, et al.
Pain Management by Chemogenetic Control of Sensory Neurons, Yize Li, Xin Ge, and Ru-Rong Ji
PANoptosis Is a Prominent Feature of Desmoplakin Cardiomyopathy, Melis Olcum, Leila Rouhi, Siyang Fan, et al.
Paradoxes of Cellular SUMOylation Regulation: A Role of Biomolecular Condensates?, Xiaodong Cheng, Wenli Yang, Wei Lin, et al.
PET Imaging of Microglia Using PBR28suv Determines Therapeutic Efficacy of Autologous Bone Marrow Mononuclear Cells Therapy in Traumatic Brain Injury, Supinder S Bedi, Michael C Scott, Max A Skibber, et al.
Plasma Cytokines/Chemokines as Predictive Biomarkers For Lymphedema in Breast Cancer Patients, Anna R Vang, Simona F Shaitelman, John C Rasmussen, et al.
Plasma Metabolites associated With Cognitive Function across Race/Ethnicities affirming the Importance of Healthy Nutrition, Einat Granot-Hershkovitz, Shan He, Jan Bressler, et al.
Polygenic Genetic Variation Affecting Antibody Formation Underlies Hypertensive Renal Injury in the Stroke-Prone Spontaneously Hypertensive Rat, Isha S Dhande, Yaming Zhu, Aniket S Joshi, et al.
Premature Senescence and Cardiovascular Disease Following Cancer Treatments: Mechanistic Insights, Ashita Jain, Diego Casanova, Alejandra Valdivia Padilla, et al.
Prospective, Early Longitudinal Assessment of Lymphedema-Related Quality of Life Among Patients With Locally Advanced Breast Cancer: The Foundation for Building a Patient-Centered Screening Program, Anusha Gandhi, Tianlin Xu, Sarah M DeSnyder, et al.
Protein Advanced Glycation End Products and Their Implications in Pancreatic Cancer, Lakmini Senavirathna, Sheng Pan, and Ru Chen
Protein SUMOylation and Phase Separation: Partners in Stress?, Xiaodong Cheng
Proteomic Analysis Identifies Circulating Proteins Associated With Plasma Amyloid-β and Incident Dementia, Adrienne Tin, Kevin J Sullivan, Keenan A Walker, et al.
Proteomics Analysis of Plasma From Middle-Aged Adults Identifies Protein Markers of Dementia Risk in Later Life, Keenan A Walker, Jingsha Chen, Liu Shi, et al.