The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2024
Genomic Analysis of Intracranial and Subcortical Brain Volumes Yields Polygenic Scores Accounting for Variation Across Ancestries, Luis M García-Marín, Adrian I Campos, Santiago Diaz-Torres, et al.
Global Trend in Exosome Isolation and Application: An Update Concept in Management of Diseases, Mohammadhassan Omrani, Hanieh Beyrampour-Basmenj, Rana Jahanban-Esfahlan, et al.
G Protein Selectivity Profile of GPR56/ADGRG1 and Its Effect on Downstream Effectors, Raida Jallouli, Ana L Moreno-Salinas, Andréanne Laniel, et al.
Histone Demethylase KDM5 Regulates Cardiomyocyte Maturation by Promoting Fatty Acid Oxidation, Oxidative Phosphorylation, and Myofibrillar Organization, Manisha Deogharia, Leslye Venegas-Zamora, Akanksha Agrawal, et al.
Human Brain Glycoform Coregulation Network and Glycan Modification Alterations in Alzheimer's Disease, Qi Zhang, Cheng Ma, Lih-Shen Chin, et al.
Hunting for Heroes: Brain Neurons Mediating GLP-1R Agonists in Obesity Treatment, Yuhan Cao and Qingchun Tong
Hypoxia-Activated Prodrug and Antiangiogenic Therapies Cooperatively Treat Pancreatic Cancer but Elicit Immunosuppressive G-MDSC Infiltration, Arthur Liu, Seth T Gammon, Federica Pisaneschi, et al.
Intracranial Volume Is Driven by Both Genetics and Early Life Exposures: The SOL-INCA-MRI Study, Tamar Sofer, Einat Granot-Hershkovitz, Wassim Tarraf, et al.
Intratumoral Biosynthesis of Gold Nanoclusters By Pancreatic Cancer To Overcome Delivery Barriers To Radiosensitization, Aaron S Schwartz-Duval, Yuri Mackeyev, Iqbal Mahmud, et al.
Itaconate Transporter SLC13A3 Impairs Tumor Immunity via Endowing Ferroptosis Resistance, Heng Lin, Kole Tison, Yuheng Du, et al.
Keep Fingers on the CpG Islands, Xing Zhang, Robert M Blumenthal, and Xiaodong Cheng
Key Variants via the Alzheimer's Disease Sequencing Project Whole Genome Sequence Data, Yanbing Wang, Chloé Sarnowski, Honghuang Lin, et al.
Large T Antigen Mediated Target Gene Replication Improves Site-Specific Recombination Efficiency, Zening Wang, Chuan Chen, and Xin Ge
Leptin Reduction as a Required Component for Weight Loss, Shangang Zhao, Na Li, Wei Xiong, et al.
LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development, Ryan Huang, Xiaoye Liu, Jaehyup Kim, et al.
LILRB4 on Multiple Myeloma Cells Promotes Bone Lesion by P-SHP2/Nf-κB/Relt Signal Pathway, Hongying Wang, Lei Wang, Huiwen Luan, et al.
Low Molecular Weight Heparin Decreases Pro-coagulant Activity in Clinical MSC Products, Jacob B Schriner, Fabio Triolo, Brijesh S Gill, et al.
Machine Learning Models for Predicting Blood Pressure Phenotypes by Combining Multiple Polygenic Risk Scores, Yana Hrytsenko, Benjamin Shea, Michael Elgart, et al.
Mechanisms and Metabolic Consequences of Adipocyte Progenitor Replicative Senescence, Tonghui Lin, Aftab Mohammad, Mikhail G Kolonin, et al.
Mechanistic Insights Into Metabolic Function of Dynamin-Related Protein 1, Xin Li, Katherine Pham, Jazmin Ysaguirre, et al.
Microglial P2Y6 Calcium Signaling Promotes Phagocytosis and Shapes Neuroimmune Responses in Epileptogenesis, Anthony D Umpierre, Bohan Li, Katayoun Ayasoufi, et al.
Microglial P2Y6 Calcium Signaling Promotes Phagocytosis and Shapes Neuroimmune Responses in Epileptogenesis, Anthony D Umpierre, Bohan Li, Katayoun Ayasoufi, et al.
MiR-29 and MiR-140 Regulate TRAIL-Induced Drug Tolerance In Lung Cancer, Suyeon Kim, Ki Wook Lee, Yongjin Yoo, et al.
Mitochondrial Permeability Transition Dictates Mitochondrial Maturation Upon Switch in Cellular Identity of Hematopoietic Precursors, Sandeep P Dumbali, Paulina D Horton, Travis I Moore, et al.
Multi-omics and Pathway Analyses of Genome-Wide Associations Implicate Regulation and Immunity in Verbal Declarative Memory Performance, Hao Mei, Jeannette Simino, Lianna Li, et al.