The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2025
DNA Double-Stranded Breaks, a Hallmark of Aging, Defined at the Nucleotide Resolution, Are Increased and Associated With Transcription in the Cardiac Myocytes in LMNA-Cardiomyopathy, Benjamin Cathcart, Sirisha M Cheedipudi, Leila Rouhi, et al.
DNA Methylation Markers of Insulin Resistance Surrogate Measures in the Atherosclerosis Risk in Communities (ARIC) Study, Jeewoen Shin, Jan Bressler, Megan L Grove, et al.
Editorial: Advances in Pharmacotherapy for Alcohol Use Disorder: From Mechanisms to Clinical Interventions, Regina A Mangieri, Sunil Sirohi, Ezequiel Marron Fernandez de Velasco, et al.
Enhanced Anticancer Activity of Novel Pyrimidine Nucleoside Analog in Pancreatic Cancer, Raviteja Bulusu, Joy Okoro, Esther Frimpong, et al.
Epac1 Deletion Attenuates Müller Glial Pathological Activation and Mitigates Retinal Neurodegeneration in Ischemia-Induced Retinopathy, Shuizhen Shi, Fan Xia, Zhongqiao Lu, et al.
Epac2 Deficiency Compromises Adaptation to Dietary Acidification by Decreasing H+ Transport in the Renal Nephron, Kyrylo Pyrshev, Anna Atamanchuk, Wenli Yang, et al.
Epidemiological Patterns and Variability in Acute Brain Injury: A Multicenter Registry Analysis in South Korea's Neurocritical Care Units, Heewon Jeong, So Hee Park, Yoon-Hee Choo, et al.
Epigenome-Wide Association Study of Incident Type 2 Diabetes in Black and White Participants From the Atherosclerosis Risk in Communities Study, Sowmya Venkataraghavan, James S Pankow, Eric Boerwinkle, et al.
Epigenome-Wide Association Study of Nuclear DNA Methylation in Relation to Mitochondrial Heteroplasmy, Meng Lai, Kyeezu Kim, Yinan Zheng, et al.
Epigenome-Wide DNA Methylation Association Study of Chip Provides Insight Into Perturbed Gene Regulation, Sara Kirmani, Tianxiao Huan, Joseph C Van Amburg, et al.
Escape of Kdm6a from X Chromosome Is Detrimental to Ischemic Brains via IRF5 Signaling, Conelius Ngwa, Afzal Misrani, Kanaka Valli Manyam, et al.
Exploratory Co-Design on Electronic Health Record Nursing Summaries: Case Study, Suhyun Park, Jenna L Marquard, Robin R Austin, et al.
Functional Characterization of QT Interval Associated SCN5A Enhancer Variants Identify Combined Additive Effects, Lavanya Gunamalai, Parul Singh, Brian Berg, et al.
Functional Regulation of Macrophages by Ces1d-Mediated Lipid Signaling in Immunometabolism, Long J Shao, Fathima Elizondo, Feng Gao, et al.
Genetic Architecture of Cerebral White Matter Hyperintensities in Diverse Hispanic/Latino Adults, Myriam Fornage, Rui Xia, Adriana Ordonez, et al.
Genome-Wide Association Study Provides Novel Insight Into the Genetic Architecture of Severe Obesity, Mohanraj Krishnan, Mohammad Yaser Anwar, Anne E Justice, et al.
Genomic and Phenotypic Correlates of Mosaic Loss of Chromosome Y in Blood, Yasminka A Jakubek, Xiaolong Ma, Adrienne M Stilp, et al.
Glutamatergic Regulation of miRNA-Containing Intraluminal Vesicle Trafficking and Extracellular Vesicle Secretion From Cortical Neurons, Marcela Bertolio, Qiyi Li, Francesca E Mowry, et al.
GSK-3484862, a DNMT1 Degrader, Promotes DNMT3B Expression in Lung Cancer Cells, Qin Chen, Swanand Hardikar, Kimie Kondo, et al.
IDH Status Dictates oHSV Mediated Metabolic Reprogramming Affecting Anti-tumor Immunity, Upasana Sahu, Matthew P Mullarkey, Sara A Murphy, et al.
Impact of Common Variants on Brain Gene Expression From RNA to Protein to Schizophrenia Risk, Qiuman Liang, Yi Jiang, Annie W Shieh, et al.
Impacts of Radiation on Metabolism and Vascular Cell Senescence, Junichi Abe, Khanh Chau, Anahita Mojiri, et al.
Insights into the Role of the Glymphatic System in the Pathogenesis of Post-hemorrhagic Hydrocephalus, Ahmed T Massoud, Dillon A Noltensmeyer, Jenifer Juranek, et al.
Islet Single-Cell Transcriptomic Profiling During Obesity-Induced Beta Cell Expansion in Female Mice, Peter M Masschelin, Scott A Ochsner, Sean M Hartig, et al.
KAP1 Promotes Gastric Adenocarcinoma Progression by Activating Hippo/YAP1 Signaling via Binding to HNRNPAB, Shumei Song, Yibo Fan, Gengyi Zou, et al.