The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2026
LGR5: From Stem Cell Marker to Therapeutic Target, Peyton C High, Maya G Cappellino, Tiffani A Blackburn, et al.
Lipids Grease the Chain of Cancer Progression, Joseph Rupert, Pham Hong Anh Cao, Daniel E Frigo, et al.
Loss of ZNRF3/RNF43 Unleashes EGRFR in Cancer, Fei Yue, Amy T Ku, Payton D Stevens, et al.
Lymphatic Pumping Failure in the Arm Precedes Dermal Backflow and Breast Cancer-Related Lymphedema, Melissa B Aldrich, Meghan E McWain, Simona F Shaitelman, et al.
MarkVCID2 Consortium for Clinical Validation of Biomarkers of Cerebral Small Vessel Disease: Validation Framework and Baseline Characteristics, Steven M Greenberg, Marylin S Albert, Hongyu An, et al.
Mechanometabolism Instructs Hematopoietic Stem Cell Specification, Paulina D Horton, Alina Syed, Michelle Winkler, et al.
Microglial SWELL1 Deficiency Drives Male-Specific Seizure Vulnerability but Paradoxical Neuroprotection Through Impaired Phagocytosis, Abhijeet S Barath, Aastha Dheer, Laura Montier, et al.
Molecular Characterization of Humanized Apoe Mouse Models Reveals Source and Genotype Dependent Differences, Na Wang, Gefei Yu, Zhen Wang, et al.
Monoclonal Antibodies Targeting PCDH7 Inhibit Tumor Growth and Enhance Immune Responses in Kras-Mutant Non-small Cell Lung Cancer, Nicole Novaresi, Poorva Ghosh, Shayna Thomas-Jardin, et al.
Multi-ancestry Genome-Wide Association Study and Meta-Analysis of Lung Function Decline, Bonnie K Patchen, Jingwen Zhang, Nathan Gaddis, et al.
Myeloid MMP14 Couples Extracellular Proteolysis to Inflammatory and Metabolic Remodeling During Obesity, Long J Shao, Fathima Elizondo, Feng Gao, et al.
Nano-Bio Interfacial Effects Modulating Protein Adsorption in Dialdehyde Lentinan-Crosslinked Polysaccharide Sponges Reinforced With Zein Nanoflowers, Dorota Chelminiak-Dudkiewicz, Miloslav Machacek, Hana Janová, et al.
Neurophysiological Connectomic Signatures of Consciousness During Propofol-Induced General Anesthesia, Yuqin Li, Xiaoxiao Chen, Hui Zheng, et al.
Neutralization of SARS-CoV-2 by IgM-14 via Engagement of Two Distinct Spike Epitopes, Yan Wang, Yanping Hu, Zhiqiang Ku, et al.
Neutrophil-Microglia Interaction Drives Motor Dysfunction in a Neuromyelitis Optica Model Induced by Subarachnoid AQP4-IgG, Fangfang Qi, Vanda A Lennon, Shunyi Zhao, et al.
Notch Signaling Regulates the Secretion of Pro-metastatic Factors in Extracellular Vesicles in Liposarcoma, Menchus Quan, Yi-Kai Liu, Ying Zhao, et al.
Overcoming IGF1R-Mediated Resistance to Oncolytic HSV1 and Radiotherapy via Triple Combination Therapy, Alexandra A Miller, Min-Hye Noh, Jin Muk Kang, et al.
Payload Diversification Overcomes Resistance and Guides Sequential Antibody-Drug Conjugate Therapy in Breast Cancer, Dileep Reddy Rampa, Minji Seo, Nanae Ogata, et al.
Personalized Management of Chronic Rhinosinusitis in the Context of Immune Deficiency, Christopher M Bell, Amber U Luong, and Chadi A Makary
Rab4 Spatially and Functionally Converges With Rab7 in the Degradative Endolysosomal Network, Stephen M Farmer, Shiyu Xu, Yue Yu, et al.
RUNX1+23 Enhancer Marks Erythro-Megakaryocyte Lineages in Early Waves of Hematopoiesis in Human Esc Differentiation, Chika Nishida, Michihiro Kobayashi, Alina Syed, et al.
Selective and Differential Roles of PVHCRH Neurotransmitters in Diet-Induced Obesity in Mice, Zhiying Jiang, Yuhan Cao, Michelle He, et al.
Selective Deletion of FGFR1 in AgRP Neurons Impairs Energy Homeostasis Under High-Fat Diet in Mice, Daniel Shookster, Shea O'Connell, Patel Darshan, et al.
SimBinder-IF: Structure-Aware Antibody Affinity Optimization via Efficient Preference Learning, Xinyan Zhao, Yi-Ching Tang, Rivaaj Monsia, et al.
Single Ventricle Physiology May Not Preclude Cardiac Repair in the Setting of Congenital Diaphragmatic Hernia, Kylie I Holden, Michael C Scott, Ashley H Ebanks, et al.