The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2024
An Excitatory Projection from the Basal Forebrain to the Ventral Tegmental Area That Underlies Anorexia-Like Phenotypes, Jing Cai, Yanyan Jiang, Yuanzhong Xu, et al.
Antibody-Activation of Connexin Hemichannels in Bone Osteocytes With ATP Release Suppresses Breast Cancer and Osteosarcoma Malignancy, Manuel A Riquelme, Xuewei Wang, Francisca M Acosta, et al.
Antitumor Activity of a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting LGR5 in Preclinical Models of Neuroblastoma, Jianghua Tu, Yukimatsu Toh, Adela M Aldana, et al.
A Revamped Rat Reference Genome Improves the Discovery of Genetic Diversity in Laboratory Rats, Tristan V de Jong, Yanchao Pan, Pasi Rastas, et al.
A Simple and Rapid In Vitro Assay for Identification of Direct Inhibitors of O6-Methylguanine-DNA Methyltransferase, Vahid Khalaj, Solmaz AghaAmiri, Sukhen C Ghosh, et al.
Association Between Symptom Burden and Early Lymphatic Abnormalities After Regional Nodal Irradiation for Breast Cancer, Alison K Yoder, Tianlin Xu, Peter Youssef, et al.
Association of Common and Rare Variants With Alzheimer’s Disease in More Than 13,000 Diverse Individuals With Whole-Genome Sequencing From the Alzheimer’s Disease Sequencing Project, Wan-Ping Lee, Seung Hoan Choi, Margaret G Shea, et al.
A Tetravalent Nanovaccine That Inhibits Growth of HPV-Associated Head and Neck Carcinoma via Dendritic and T Cell Activation, Romano Josi, Daniel E Speiser, Simone de Brot, et al.
Autologous Bone Marrow Mononuclear Cells to Treat Severe Traumatic Brain Injury in Children, Charles S Cox, David M Notrica, Jenifer Juranek, et al.
BIGH3 Mediates Apoptosis and Gap Junction Failure in Osteocytes During Renal Cell Carcinoma Bone Metastasis Progression, Tianhong Pan, Fengshuo Liu, Xiaoxin Hao, et al.
Biological Validation of Peak-Width of Skeletonized Mean Diffusivity as a VCID Biomarker: The MarkVCID Consortium, Alison M Luckey, Saptaparni Ghosh, Chen-Pin Wang, et al.
Blocking Oncostatin M Receptor Abrogates STAT3 Mediated Integrin Signaling and Overcomes Chemoresistance in Ovarian Cancer, Anjali Geethadevi, Zhiqiang Ku, Shirng-Wern Tsaih, et al.
C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies, Xing Zhang, Fangfang Xia, Xiaotian Zhang, et al.
Case Report: The Effect of Automated Manual Lymphatic Drainage Therapy on Lymphatic Contractility in 4 Distinct Cases, Melissa B Aldrich, John C Rasmussen, Ron J Karni, et al.
CCR2+ Monocytes Replenish Border-Associated Macrophages in the Diseased Mouse Brain, Lingxiao Wang, Jiaying Zheng, Shunyi Zhao, et al.
Cell-Specific Regulation of the Circadian Clock by BMAL1 in the Paraventricular Nucleus: Implications for Regulation of Systemic Biological Rhythms, Rachel Van Drunen, Yulin Dai, Haichao Wei, et al.
Cholinergic Basal Forebrain Connectivity to the Basolateral Amygdala Modulates Food Intake, Joshua Ortiz-Guzman, Jessica L Swanson, Evelyne K Tantry, et al.
Consensus Pharmacophore Strategy For Identifying Novel SARS-Cov-2 Mpro Inhibitors from Large Chemical Libraries, Angel J Ruiz-Moreno, Raziel Cedillo-González, Luis Cordova-Bahena, et al.
Construction and Evaluation of a New Rat Reference Genome Assembly, GRCr8, From Long Reads and Long-Range Scaffolding, Kai Li, Melissa L Smith, J Chris Blazier, et al.
Cytokine Release by Microglia Exposed to Neurologic Injury Is Amplified by Lipopolysaccharide, Michael C Scott, Olivia LeBlanc, Harper Day, et al.
Data Normalization for Addressing the Challenges in the Analysis of Single-Cell Transcriptomic Datasets, Raquel Cuevas-Diaz Duran, Haichao Wei, and Jiaqian Wu
Determinants of Mosaic Chromosomal Alteration Fitness, Yash Pershad, Taralynn Mack, Hannah Poisner, et al.
Differential Lipid Binding Specificities of RAP1A and RAP1B are Encoded by the Amino Acid Sequence of the Membrane Anchors, Mussie K Araya, Wei Chen, Yuepeng Ke, et al.
Distinct Basal Forebrain-Originated Neural Circuits Promote Homoeostatic Feeding and Suppress Hedonic Feeding in Male Mice, Hailan Liu, Jonathan C Bean, Yongxiang Li, et al.
DNA-Binding Proteins From MBD Through ZF to BEN: Recognition of Cytosine Methylation Status by One Arginine With Two Conformations, Xing Zhang, Robert M Blumenthal, and Xiaodong Cheng