The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.

Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.

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Submissions from 2025

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Leptin as a Key Driver for Organ Fibrogenesis, Xue-Nan Sun, Shiuhwei Chen, Shangang Zhao, et al.

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Limitations of the Radiotheranostic Concept in Neuroendocrine Tumors Due to Lineage-Dependent Somatostatin Receptor Expression on Hematopoietic Stem and Progenitor Cells, Nghia Nguyen, Yu Min, Jennifer Rivière, et al.

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Longitudinal Associations of Epigenetic Aging With Cognitive Aging in Hispanic/Latino Adults From the Hispanic Community Health Study/Study of Latinos, Myriam Fornage, Wassim Tarraf, Rui Xia, et al.

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Mapping Cardiac Electrical Abnormalities in Rodents, Ashish Kapoor and Peter A Doris

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Mechanisms and Environmental Factors Shaping the Ecosystem of Brain Macrophages, Silvia Penati, Simone Brioschi, Zhangying Cai, et al.

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Methylation Risk Score of C-reactive Protein Associates Sleep Health With Related Health Outcomes, Ziqing Wang, Danielle A Wallace, Brian W Spitzer, et al.

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Methylome-Wide Association Analyses of Lipids and Modifying Effects of Behavioral Factors in Diverse Race and Ethnicity Participants, Yao Hu, Jeff Haessler, Jessica I Lundin, et al.

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Microglial Phagocytosis in Epilepsy: Mechanisms and Impact, Abhijeet S Barath and Long-Jun Wu

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MT1-Mmp Inhibition Rejuvenates Ageing Brain and Rescues Cognitive Deficits in Obesity, Pallavi Asthana, Liguo Li, Lin Lu, et al.

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Multi-ancestry Genome-Wide Association Analyses Incorporating SNP-by-Psychosocial Interactions Identify Novel Loci for Serum Lipids, Amy R Bentley, Michael R Brown, Solomon K Musani, et al.

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Multifaceted Roles of Epac Signaling in Renal Functions, Oleh Pochynyuk, Kyrylo Pyrshev, and Xiaodong Cheng

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Multimeric Transcription Factor BCL11A Utilizes Two Zinc-Finger Tandem Arrays To Bind Clustered Short Sequence Motifs, John R Horton, Meigen Yu, Jujun Zhou, et al.

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Multimodal Approach in Distinguishing and Managing Uterine Arteriovenous Malformation: A Case Report, Sajeev Sridhar, Roman Sukhovershin, and John A Hancock

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Nuclear poly(A)-Binding Protein and Nucleolin Utilize Their RNA Recognition Motifs to Read Par Chains, Leilei Shi, Morgan Dasovich, John R Horton, et al.

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Perioperative Fluid Therapy Impairs Lymphatic Pump Function in Male Rats, Rebecca C Harlow-Adamek, Reetu Singh, Randolph H Stewart, et al.

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Plasma Proteomic Characterization of Motoric Cognitive Risk and Mild Cognitive Impairment, Gabriela T Gomez, Sanish Sathyan, Jingsha Chen, et al.

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Polygenic Prediction of Body Mass Index and Obesity Through the Life Course and Across Ancestries, Roelof A J Smit, Kaitlin H Wade, Qin Hui, et al.

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Polygenic Scores for Obstructive Sleep Apnoea Reveal Pathways Contributing to Cardiovascular Disease, Nuzulul Kurniansyah, Satu J Strausz, Geetha Chittoor, et al.

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Preclinical Evaluation of Closed Incisional Negative Pressure Therapy on Post-Surgical Oedema and Lymphatic Activity, John C Rasmussen, Marisa Schmidt, Janelle E Morton, et al.

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Predicting Sinonasal Inverted Papilloma Attachment Using Machine Learning: Current Lessons and Future Directions, Sean P McKee, Xiaomin Liang, William C Yao, et al.

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Prefrontal Cortex Astrocytes Modulate Distinct Neuronal Populations To Control Anxiety-Like Behavior, Eunyoung Kim, Hairuo Du, Yanqi Tan, et al.

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Prevalence of Local IgE Elevation and Its Effect on Intranasal Capsaicin Therapy in the Nonallergic Rhinitis Population, Kunal R Shetty, Salman Hasan, Christopher Bankston, et al.

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Principles and Practice in Pediatric Vascular Trauma: Part 1: Scope of Problem, Team Structure, Multidisciplinary Dynamics, and Solutions, Matthew T Harting, Natalie A Drucker, Mary T Austin, et al.

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Prolonged Exposure to Food Odors Suppresses Feeding via an Olfactory Bulb-to-Hypothalamus Circuit, Yao Liu, Hailan Liu, Huey-Xian Kelly Wong, et al.

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RBM39 Contributes to MGMT Maintenance in Response to Temozolomide-Induced DNA Damage, Vahid Khalaj, Jack T Adams, Solmaz AghaAmiri, et al.