The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2024
Cell-Specific Regulation of the Circadian Clock by BMAL1 in the Paraventricular Nucleus: Implications for Regulation of Systemic Biological Rhythms, Rachel Van Drunen, Yulin Dai, Haichao Wei, et al.
Cholinergic Basal Forebrain Connectivity to the Basolateral Amygdala Modulates Food Intake, Joshua Ortiz-Guzman, Jessica L Swanson, Evelyne K Tantry, et al.
Consensus Pharmacophore Strategy For Identifying Novel SARS-Cov-2 Mpro Inhibitors from Large Chemical Libraries, Angel J Ruiz-Moreno, Raziel Cedillo-González, Luis Cordova-Bahena, et al.
Construction and Evaluation of a New Rat Reference Genome Assembly, GRCr8, From Long Reads and Long-Range Scaffolding, Kai Li, Melissa L Smith, J Chris Blazier, et al.
Cytokine Release by Microglia Exposed to Neurologic Injury Is Amplified by Lipopolysaccharide, Michael C Scott, Olivia LeBlanc, Harper Day, et al.
Data Normalization for Addressing the Challenges in the Analysis of Single-Cell Transcriptomic Datasets, Raquel Cuevas-Diaz Duran, Haichao Wei, and Jiaqian Wu
Determinants of Mosaic Chromosomal Alteration Fitness, Yash Pershad, Taralynn Mack, Hannah Poisner, et al.
Differential Lipid Binding Specificities of RAP1A and RAP1B are Encoded by the Amino Acid Sequence of the Membrane Anchors, Mussie K Araya, Wei Chen, Yuepeng Ke, et al.
Distinct Basal Forebrain-Originated Neural Circuits Promote Homoeostatic Feeding and Suppress Hedonic Feeding in Male Mice, Hailan Liu, Jonathan C Bean, Yongxiang Li, et al.
DNA-Binding Proteins From MBD Through ZF to BEN: Recognition of Cytosine Methylation Status by One Arginine With Two Conformations, Xing Zhang, Robert M Blumenthal, and Xiaodong Cheng
DNA Methylation in Aging and Alzheimer's Disease, Raymond Cheng, Jingmin Shu, Hai Chen, et al.
Dopaminergic Neurons in Zona Incerta Drives Appetitive Self-Grooming, Zhiying Jiang, Michelle He, Claire Young, et al.
Dysregulation of Epigenetic Modifications in Inborn Errors of Immunity, Zhongyao Xiao, Rongjing He, Zihan Zhao, et al.
Editorial: Advances and Methods in Mesenchymal Stem Cells, Pamela L Wenzel
Efficient Gene Knockout and Genetic Interaction Screening Using the in4mer CRISPR/Cas12a Multiplex Knockout Platform, Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, et al.
Endolysosomal Trafficking Controls Yolk Granule Biogenesis in Vitellogenic Drosophila Oocytes, Yue Yu, Dongsheng Chen, Stephen M Farmer, et al.
Endothelial-specific Telomerase Inactivation Causes Telomere-independent Cell Senescence and Multi-organ Dysfunction Characteristic of Aging, Zhanguo Gao, Rafael Bravo Santos, Joseph Rupert, et al.
Endotrophin, a Key Marker and Driver for Fibroinflammatory Disease, Kim Henriksen, Federica Genovese, Alexander Reese-Petersen, et al.
Endotrophin as a Biomarker for Severe Acute Kidney Injury and Major Adverse Kidney Events, Alexander H Flannery, Dawei Bu, Madison Botkins, et al.
Epigenetic Regulation of Heart Failure, Manisha Deogharia and Priyatansh Gurha
Evaluating Performance and Applications of Sample-Wise Cell Deconvolution Methods on Human Brain Transcriptomic Data, Rujia Dai, Tianyao Chu, Ming Zhang, et al.
Exploring the Potential of Epiregulin and Amphiregulin as Prognostic, Predictive, and Therapeutic Targets in Colorectal Cancer, Cara Guernsey-Biddle, Peyton High, and Kendra S Carmon
Familial Hypercholesterolemia Variant and Cardiovascular Risk in Individuals With Elevated Cholesterol, Yiyi Zhang, Jacqueline S Dron, Brandon K Bellows, et al.
FC Engineering by Monoclonal Mammalian Cell Display for Improved Affinity and Selectivity Towards FcγRs, Zening Wang, Minhyo Kang, Afshin Ebrahimpour, et al.
FC Gamma Receptors Promote Antibody-Induced LILRB4 Internalization and Immune Regulation of Monocytic AML, Joshua W Morse, Xun Gui, Mi Deng, et al.