The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2024
Proteomics in Orthopedic Research: Recent Studies and Their Translational Implications, George Li, Argyrios Stampas, Yoshihiro Komatsu, et al.
Quinoline-Based Compounds Can Inhibit Diverse Enzymes That Act on DNA, Jujun Zhou, Qin Chen, Ren Ren, et al.
Rare Variant Contribution to the Heritability of Coronary Artery Disease, Ghislain Rocheleau, Shoa L Clarke, Gaëlle Auguste, et al.
Sample Multiplexing for Retinal Single-Cell RNA Sequencing, Justin Ma, Ting-Kuan Chu, Maria Polo-Prieto, et al.
SARS-CoV-2 Omicron: Viral Evolution, Immune Evasion, and Alternative Durable Therapeutic Strategies, Hailong Guo, Sha Ha, Jason W Botten, et al.
SART3 Reads Methylarginine-Marked Glycine- and Arginine-Rich Motifs, Yalong Wang, Jujun Zhou, Wei He, et al.
Somatostatin Receptor Subtype-2 Targeting System for Specific Delivery of Temozolomide, Solmaz AghaAmiri, Sukhen C Ghosh, Servando Hernandez Vargas, et al.
Tau Is Required for Glial Lipid Droplet Formation and Resistance to Neuronal Oxidative Stress, Lindsey D Goodman, Isha Ralhan, Xin Li, et al.
TFEB Controls Syncytiotrophoblast Formation and Hormone Production in Placenta, Marcella Cesana, Gennaro Tufano, Francesco Panariello, et al.
The Evolving Paradigm of Antibody-Drug Conjugates Targeting the ErbB/HER Family of Receptor Tyrosine Kinases, Peyton High, Cara Guernsey, Shraddha Subramanian, et al.
The Hepatokine Orosomucoid 2 Mediates Beneficial Metabolic Effects of Bile Acids, Sung Ho Lee, Ji Ho Suh, Mi Jeong Heo, et al.
The ICF Syndrome Protein CDCA7 Harbors a Unique DNA Binding Domain That Recognizes a CpG Dyad in the Context of a Non-B DNA, Swanand Hardikar, Ren Ren, Zhengzhou Ying, et al.
Transcriptional Signature of Durable Effector T Cells Elicited By A Replication Defective HCMV Vaccine, Xiaohua Ye, David J H Shih, Zhiqiang Ku, et al.
Translational Potential of a Contrast Agent for FGS Applications in pNETs, Solmaz AghaAmiri, Jeannelyn S Estrella, Servando Hernandez Vargas, et al.
TREX2 Deficiency Suppresses Spontaneous and Genotoxin-Associated Mutagenesis, Teresa Marple, Mi Young Son, Xiaodong Cheng, et al.
TRIM44, a Novel Prognostic Marker, Supports the Survival of Proteasome-Resistant Multiple Myeloma Cells, Trung Vu, Yuqin Wang, Annaliese Fowler, et al.
TRIM44 Enhances Autophagy via SQSTM1 Oligomerization in Response to Oxidative Stress, Yuqin Wang, Lin Lyu, Trung Vu, et al.
Tumor-Infiltrating Mast Cells Confer Resistance to Immunotherapy in Pancreatic Cancer, Ying Ma, Xiangqin Zhao, Jingyan Feng, et al.
Updated Understanding of the Protein-DNA Recognition Code Used by C2H2 Zinc Finger Proteins, Xing Zhang, Robert M Blumenthal, and Xiaodong Cheng
Validation of Human Telomere Length Multi-Ancestry Meta-Analysis Association Signals Identifies POP5 and KBTBD6 as Human Telomere Length Regulation Genes, Rebecca Keener, Surya B Chhetri, Carla J Connelly, et al.
Whole Genome Sequencing Based Analysis of Inflammation Biomarkers in the Trans-omics for Precision Medicine (TOPMed) Consortium, Min-Zhi Jiang, Sheila M Gaynor, Xihao Li, et al.
Submissions from 2023
Aberrant Activation of TCL1A Promotes Stem Cell Expansion in Clonal Haematopoiesis, Joshua S Weinstock, Jayakrishnan Gopakumar, Bala Bharathi Burugula, et al.
A Complete Methyl-Lysine Binding Aromatic Cage Constructed by Two Domains of PHF2, John R Horton, Jujun Zhou, Qin Chen, et al.
A Decade of Blood-Brain Barrier Permeability Assays: Revisiting Old Traumatic Brain Injury Rat Data For New Insights and Experimental Design, Chris T Bolden, Scott D Olson, and Charles S Cox
Advances in the Treatment of Invasive Fungal Disease, Zhuan Zhang, Gerald F Bills, and Zhiqiang An