The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2025
Disentangling Unobserved Heterogeneity: Novel Application of a Statistical Method to Evaluate a Multilevel Healthcare Intervention for Hispanic Individuals Living on the United States-Mexico Border With Comorbid Diabetes and Hypertension, MinJae Lee, Juliana Z Lopez, Natalia I Heredia, et al.
DNA Double-Stranded Breaks, a Hallmark of Aging, Defined at the Nucleotide Resolution, Are Increased and Associated With Transcription in the Cardiac Myocytes in LMNA-Cardiomyopathy, Benjamin Cathcart, Sirisha M Cheedipudi, Leila Rouhi, et al.
DNA Methylation Markers of Insulin Resistance Surrogate Measures in the Atherosclerosis Risk in Communities (ARIC) Study, Jeewoen Shin, Jan Bressler, Megan L Grove, et al.
Editorial: Advances in Pharmacotherapy for Alcohol Use Disorder: From Mechanisms to Clinical Interventions, Regina A Mangieri, Sunil Sirohi, Ezequiel Marron Fernandez de Velasco, et al.
Effects of Olfactory Enrichment on Perioperative Neurocognitive Disorders in Elderly Patients Undergoing Orthopedic Surgery: A Study Protocol of a Multi-center Randomized Controlled Trial, Xinchun Mei, Jiayi Wang, Zihan Ni, et al.
Efficacy of Platelet Rich Plasma Versus Placebo for Improvement in Olfactory Function in Adults With Olfactory Dysfunction: A Systematic Review and Meta-Analysis, Ali B Jafar, Ghabrielle Almeida, Fatima Al Mousawi, et al.
Enhanced Anticancer Activity of Novel Pyrimidine Nucleoside Analog in Pancreatic Cancer, Raviteja Bulusu, Joy Okoro, Esther Frimpong, et al.
Enigmatic Roles of Complement Anaphylatoxin Signaling in Health and Disease, Anthony Shadid, Kathryn D Hok, Aleksey Y Domozhirov, et al.
Epac1 Deletion Attenuates Müller Glial Pathological Activation and Mitigates Retinal Neurodegeneration in Ischemia-Induced Retinopathy, Shuizhen Shi, Fan Xia, Zhongqiao Lu, et al.
Epac2 Deficiency Compromises Adaptation to Dietary Acidification by Decreasing H+ Transport in the Renal Nephron, Kyrylo Pyrshev, Anna Atamanchuk, Wenli Yang, et al.
Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development, Yubo He, Chengcheng Zhang, Lingxiao Tan, et al.
Epidemiological Patterns and Variability in Acute Brain Injury: A Multicenter Registry Analysis in South Korea's Neurocritical Care Units, Heewon Jeong, So Hee Park, Yoon-Hee Choo, et al.
Epigenome-Wide Association Study of Incident Type 2 Diabetes in Black and White Participants From the Atherosclerosis Risk in Communities Study, Sowmya Venkataraghavan, James S Pankow, Eric Boerwinkle, et al.
Epigenome-Wide Association Study of Nuclear DNA Methylation in Relation to Mitochondrial Heteroplasmy, Meng Lai, Kyeezu Kim, Yinan Zheng, et al.
Epigenome-Wide DNA Methylation Association Study of Chip Provides Insight Into Perturbed Gene Regulation, Sara Kirmani, Tianxiao Huan, Joseph C Van Amburg, et al.
Escape of Kdm6a from X Chromosome Is Detrimental to Ischemic Brains via IRF5 Signaling, Conelius Ngwa, Afzal Misrani, Kanaka Valli Manyam, et al.
Estrogen-Related Receptor Alpha Promotes Skeletal Muscle Regeneration and Mitigates Muscular Dystrophy, Thi Thu Hao Nguyen, Ya Xiang Huang, Svitlana Poliakova, et al.
Exploratory Co-Design on Electronic Health Record Nursing Summaries: Case Study, Suhyun Park, Jenna L Marquard, Robin R Austin, et al.
Frequency of Variants in Mendelian Alzheimer’s Disease Genes Within the Alzheimer’s Disease Sequencing Project, Dongyu Wang, Alexandra Scalici, Yanbing Wang, et al.
Functional Characterization of QT Interval Associated SCN5A Enhancer Variants Identify Combined Additive Effects, Lavanya Gunamalai, Parul Singh, Brian Berg, et al.
Functional Regulation of Macrophages by Ces1d-Mediated Lipid Signaling in Immunometabolism, Long J Shao, Fathima Elizondo, Feng Gao, et al.
Functional Roles of the Complement Immune System in Cardiac Inflammation and Hypertrophy, Kathryn D Hok, Haydn E Rich, Anthony Shadid, et al.
General Kernel Machine Methods for Multi-Omics Integration and Genome-Wide Association Testing With Related Individuals, Amarise Little, Ni Zhao, Anna Mikhaylova, et al.
Genetic Architecture of Cerebral White Matter Hyperintensities in Diverse Hispanic/Latino Adults, Myriam Fornage, Rui Xia, Adriana Ordonez, et al.
Genetic Underpinnings of the Heterogeneous Impact of Obesity on Lipid Levels and Cardiovascular Disease, Daeeun Kim, Heather M Highland, Roelof A J Smit, et al.