The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2025
WMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study, Charles DeCarli, Kumar B Rajan, Lee-Way Jin, et al.
Submissions from 2024
Admixture Mapping of Cognitive Function in Diverse Hispanic and Latino Adults: Results From the Hispanic Community Health Study/Study of Latinos, Rui Xia, Xueqiu Jian, Amanda L Rodrigue, et al.
A Genetic Association Study of Circulating Coagulation Factor VIII and Von Willebrand Factor Levels, Paul S de Vries, Paula Reventun, Michael R Brown, et al.
A Light-Responsive Neural Circuit Suppresses Feeding, Hailan Liu, Na Qu, Natalia Valdez Gonzalez, et al.
Androgen Deprivation Induces Neuroendocrine Phenotypes in Prostate Cancer Cells Through CREB1/EZH2-Mediated Downregulation of Rest, Dayong Zheng, Yan Zhang, Sukjin Yang, et al.
An Excitatory Projection from the Basal Forebrain to the Ventral Tegmental Area That Underlies Anorexia-Like Phenotypes, Jing Cai, Yanyan Jiang, Yuanzhong Xu, et al.
An Expanded Chronic Care Management Approach to Multiple Chronic Conditions in Hispanics Using Community Health Workers as Community Extenders in the Rio Grande Valley of Texas, Juliana Z Lopez, MinJae Lee, Soo K Park, et al.
An Inducible Genetic Tool To Track and Manipulate Specific Microglial States Reveals Their Plasticity and Roles in Remyelination, Kia M Barclay, Nora Abduljawad, Zuolin Cheng, et al.
Antibody-Activation of Connexin Hemichannels in Bone Osteocytes With ATP Release Suppresses Breast Cancer and Osteosarcoma Malignancy, Manuel A Riquelme, Xuewei Wang, Francisca M Acosta, et al.
Antibody-Mediated Targeting of Human Microglial Leukocyte Ig-Like Receptor B4 Attenuates Amyloid Pathology in a Mouse Model, Jinchao Hou, Yun Chen, Zhangying Cai, et al.
Antitumor Activity of a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting LGR5 in Preclinical Models of Neuroblastoma, Jianghua Tu, Yukimatsu Toh, Adela M Aldana, et al.
Anxiety-Like Behaviors in Mice Unmasked: Revealing Sex Differences in Anxiety Using a Novel Light-Heat Conflict Test, Sydney E Lee, Sung-Hoon Park, John C Aldrich, et al.
A Revamped Rat Reference Genome Improves the Discovery of Genetic Diversity in Laboratory Rats, Tristan V de Jong, Yanchao Pan, Pasi Rastas, et al.
A Simple and Rapid In Vitro Assay for Identification of Direct Inhibitors of O6-Methylguanine-DNA Methyltransferase, Vahid Khalaj, Solmaz AghaAmiri, Sukhen C Ghosh, et al.
Association Between Symptom Burden and Early Lymphatic Abnormalities After Regional Nodal Irradiation for Breast Cancer, Alison K Yoder, Tianlin Xu, Peter Youssef, et al.
Association of Common and Rare Variants With Alzheimer’s Disease in More Than 13,000 Diverse Individuals With Whole-Genome Sequencing From the Alzheimer’s Disease Sequencing Project, Wan-Ping Lee, Seung Hoan Choi, Margaret G Shea, et al.
A Tetravalent Nanovaccine That Inhibits Growth of HPV-Associated Head and Neck Carcinoma via Dendritic and T Cell Activation, Romano Josi, Daniel E Speiser, Simone de Brot, et al.
Autologous Bone Marrow Mononuclear Cells to Treat Severe Traumatic Brain Injury in Children, Charles S Cox, David M Notrica, Jenifer Juranek, et al.
Azithromycin Reduces Hemoglobin-Induced Innate Neuroimmune Activation, Chirayu D Pandya, Hemendra J Vekaria, Miriam Zamorano, et al.
BIGH3 Mediates Apoptosis and Gap Junction Failure in Osteocytes During Renal Cell Carcinoma Bone Metastasis Progression, Tianhong Pan, Fengshuo Liu, Xiaoxin Hao, et al.
Biological Validation of Peak-Width of Skeletonized Mean Diffusivity as a VCID Biomarker: The MarkVCID Consortium, Alison M Luckey, Saptaparni Ghosh, Chen-Pin Wang, et al.
Blocking Oncostatin M Receptor Abrogates STAT3 Mediated Integrin Signaling and Overcomes Chemoresistance in Ovarian Cancer, Anjali Geethadevi, Zhiqiang Ku, Shirng-Wern Tsaih, et al.
C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies, Xing Zhang, Fangfang Xia, Xiaotian Zhang, et al.
Case Report: The Effect of Automated Manual Lymphatic Drainage Therapy on Lymphatic Contractility in 4 Distinct Cases, Melissa B Aldrich, John C Rasmussen, Ron J Karni, et al.
CCR2+ Monocytes Replenish Border-Associated Macrophages in the Diseased Mouse Brain, Lingxiao Wang, Jiaying Zheng, Shunyi Zhao, et al.