The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2025
Aging in Mice Alters Regionally Enriched Striatal Astrocytes, Kay E Linker, Violeta Duran-Laforet, Matthias Ollivier, et al.
A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals From Diverse Populations, Pavithra Nagarajan, Thomas W Winkler, Amy R Bentley, et al.
Allergic Fungal Rhinosinusitis Diagnosis, Management, Associated Conditions, Pathophysiology, and Future Directions: Summary of a Multidisciplinary Workshop, Lauren T Roland, Cecelia Damask, Amber U Luong, et al.
An Alternative Neural Basis Underlying Leptin Resistance, Hongli Li, Cunjin Su, Yuanzhong Xu, et al.
An Intranasally Administered IgM Protects Against Antigenically Distinct Subtypes of Influenza a Viruses, Ashwin Kumar Ramesh, Jwala Priyadarsini Sivaccumar, Xiaohua Ye, et al.
Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer, Joan Jacob, Yasuaki Anami, Peyton C High, et al.
Anti-Tumor Activity of Camptothecin Analog Conjugate of an RSPO4-Based Peptibody Targeting LGR4/5/6 in Preclinical Models of Colorectal Cancer, Yukimatsu Toh, Ling Wu, Jianghua Tu, et al.
Association of Epigenetic Age Acceleration and Mitochondrial DNA-Based Aging Metrics Provides Insights Into Mechanisms of Aging-Related Diseases, Mengyao Wang, Yinan Zheng, Meng Lai, et al.
Association of Epigenetic Aging With Plasma Cbiomarkers of Amyloid, Tau, Neurodegeneration, and Neuroinflammation in Hispanic/Latino Adults, Myriam Fornage, Wassim Tarraf, Martha L Daviglus, et al.
Association of Genetic Scores Related to Insulin Resistance With Neurological Outcomes in Ancestrally Diverse Cohorts From the Trans-Omics for Precision Medicine (TOPMed) Program, Chloé Sarnowski, Yixin Zhang, Farah Ammous, et al.
A Statistical Framework for Multi-Trait Rare Variant Analysis in Large-Scale Whole-Genome Sequencing Studies, Xihao Li, Han Chen, Margaret Sunitha Selvaraj, et al.
A Sumo-Interacting Motif in the Guanine Nucleotide Exchange Factor EPAC1 Is Required for Subcellular Targeting and Function, Wenli Yang, Fang Mei, Wei Lin, et al.
A Switch Protein Adapter for Anti-LILRB4 CAR-T Cells, Ryan Huang, Heyu Chen, Jingjing Xie, et al.
A Systematic Review and Evaluation of Mobile Health Apps Designed for Parents Who Are Preparing or Caring for Medically Complex Infants, Anne Chevalier McKechnie, Nellie Munn Swanson, Ratchada Jantraporn, et al.
Bile Acid Regulation of Xenobiotic Nuclear Receptors on the Expressions of Orosomucoids in the Liver, Ji Ho Suh, Inyoung Cheon, Hyun-Jung Jung, et al.
Brain-Wide Patterns of CRF Receptor 1 Expression in the Transgenic CRFR1-Cre-2a-tdTom Rat, Douglas S Engelke, Lierni Ugartemendia, Jonathan Tao, et al.
Caloric Restriction and Telomere Preservation in TERT Knockout Adipocyte Progenitors Does Not Rescue Mice From Metabolic Dysfunction due to a TERT Function in Adipocyte Mitochondria., Zhanguo Gao, Yongmei Yu, Kristin Eckel-Mahan, et al.
Cetuximab Increases LGR5 Expression and Augments LGR5-Targeting Antibody-Drug Conjugate Efficacy in Patient-Derived Colorectal Cancer Models, Peyton C High, Zhengdong Liang, Cara Guernsey-Biddle, et al.
Chemogenetic Activation of Microglial Gi Signaling Decreases Microglial Surveillance and Impairs Neuronal Synchronization, Shunyi Zhao, Lingxiao Wang, Dimitrios Kleidonas, et al.
Complement Activity and Autophagy Are Dysregulated in the Lungs of Patients With Nonresolvable COVID-19 Requiring Lung Transplantation, Pooja Shivshankar, Stacey L Mueller-Ortiz, Aleksey Y Domozhirov, et al.
Cord Blood Treatment for Children With Cerebral Palsy: Individual Participant Data Meta-Analysis, Megan Finch-Edmondson, Madison C B Paton, Annabel Webb, et al.
Correction: Complement Activity and Autophagy Are Dysregulated in the Lungs of Patients With Nonresolvable COVID-19 Requiring Lung Transplantation, Pooja Shivshankar, Stacey L Mueller-Ortiz, Aleksey Y Domozhirov, et al.
DDT Exposure Induces Microglial Activation and Disease-Associated Microglial Signatures: Relevance to Mechanisms of Alzheimer’s Disease, Isha Mhatre-Winters, Aseel Eid, Nicole Blum, et al.
Decreased Proliferation of HepG2 Liver Cancer Cells In Vitro and Exhibited Proteomic Changes In Vivo in Subjects With Metabolic Syndrome and Metabolic Dysfunction-Associated Steatotic Liver Disease Who Performed Four-Week Dawn-to-Dusk Dry Fasting, Ayse L Mindikoglu, Kristin Eckel-Mahan, Antone R Opekun, et al.
Disentangling Unobserved Heterogeneity: Novel Application of a Statistical Method to Evaluate a Multilevel Healthcare Intervention for Hispanic Individuals Living on the United States-Mexico Border With Comorbid Diabetes and Hypertension, MinJae Lee, Juliana Z Lopez, Natalia I Heredia, et al.