The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2025
Functional Regulation of Macrophages by Ces1d-Mediated Lipid Signaling in Immunometabolism, Long J Shao, Fathima Elizondo, Feng Gao, et al.
Genome-Wide Association Study Provides Novel Insight Into the Genetic Architecture of Severe Obesity, Mohanraj Krishnan, Mohammad Yaser Anwar, Anne E Justice, et al.
Genomic and Phenotypic Correlates of Mosaic Loss of Chromosome Y in Blood, Yasminka A Jakubek, Xiaolong Ma, Adrienne M Stilp, et al.
Glutamatergic Regulation of miRNA-Containing Intraluminal Vesicle Trafficking and Extracellular Vesicle Secretion From Cortical Neurons, Marcela Bertolio, Qiyi Li, Francesca E Mowry, et al.
GSK-3484862, a DNMT1 Degrader, Promotes DNMT3B Expression in Lung Cancer Cells, Qin Chen, Swanand Hardikar, Kimie Kondo, et al.
IDH Status Dictates oHSV Mediated Metabolic Reprogramming Affecting Anti-tumor Immunity, Upasana Sahu, Matthew P Mullarkey, Sara A Murphy, et al.
Islet Single-Cell Transcriptomic Profiling During Obesity-Induced Beta Cell Expansion in Female Mice, Peter M Masschelin, Scott A Ochsner, Sean M Hartig, et al.
KAP1 Promotes Gastric Adenocarcinoma Progression by Activating Hippo/YAP1 Signaling via Binding to HNRNPAB, Shumei Song, Yibo Fan, Gengyi Zou, et al.
Limitations of the Radiotheranostic Concept in Neuroendocrine Tumors Due to Lineage-Dependent Somatostatin Receptor Expression on Hematopoietic Stem and Progenitor Cells, Nghia Nguyen, Yu Min, Jennifer Rivière, et al.
Longitudinal Associations of Epigenetic Aging With Cognitive Aging in Hispanic/Latino Adults From the Hispanic Community Health Study/Study of Latinos, Myriam Fornage, Wassim Tarraf, Rui Xia, et al.
Methylome-Wide Association Analyses of Lipids and Modifying Effects of Behavioral Factors in Diverse Race and Ethnicity Participants, Yao Hu, Jeff Haessler, Jessica I Lundin, et al.
Microglial Phagocytosis in Epilepsy: Mechanisms and Impact, Abhijeet S Barath and Long-Jun Wu
MT1-Mmp Inhibition Rejuvenates Ageing Brain and Rescues Cognitive Deficits in Obesity, Pallavi Asthana, Liguo Li, Lin Lu, et al.
Multi-ancestry Genome-Wide Association Analyses Incorporating SNP-by-Psychosocial Interactions Identify Novel Loci for Serum Lipids, Amy R Bentley, Michael R Brown, Solomon K Musani, et al.
Multifaceted Roles of Epac Signaling in Renal Functions, Oleh Pochynyuk, Kyrylo Pyrshev, and Xiaodong Cheng
Multimeric Transcription Factor BCL11A Utilizes Two Zinc-Finger Tandem Arrays To Bind Clustered Short Sequence Motifs, John R Horton, Meigen Yu, Jujun Zhou, et al.
Multimodal Approach in Distinguishing and Managing Uterine Arteriovenous Malformation: A Case Report, Sajeev Sridhar, Roman Sukhovershin, and John A Hancock
Orphan Nuclear Receptor 4A1 (NR4A1) and NR4A2 Are Endogenous Regulators of CD71 and Their Ligands Induce Ferroptosis in Breast Cancer, Arafat Rahman Oany, Srijana Upadhyay, Wai Ning Tiffany Tsui, et al.
Perioperative Fluid Therapy Impairs Lymphatic Pump Function in Male Rats, Rebecca C Harlow-Adamek, Reetu Singh, Randolph H Stewart, et al.
Plasma Proteomic Characterization of Motoric Cognitive Risk and Mild Cognitive Impairment, Gabriela T Gomez, Sanish Sathyan, Jingsha Chen, et al.
Polygenic Scores for Obstructive Sleep Apnoea Reveal Pathways Contributing to Cardiovascular Disease, Nuzulul Kurniansyah, Satu J Strausz, Geetha Chittoor, et al.
Preclinical Evaluation of Closed Incisional Negative Pressure Therapy on Post-Surgical Oedema and Lymphatic Activity, John C Rasmussen, Marisa Schmidt, Janelle E Morton, et al.
Predicting Sinonasal Inverted Papilloma Attachment Using Machine Learning: Current Lessons and Future Directions, Sean P McKee, Xiaomin Liang, William C Yao, et al.
Prefrontal Cortex Astrocytes Modulate Distinct Neuronal Populations To Control Anxiety-Like Behavior, Eunyoung Kim, Hairuo Du, Yanqi Tan, et al.
Prolonged Exposure to Food Odors Suppresses Feeding via an Olfactory Bulb-to-Hypothalamus Circuit, Yao Liu, Hailan Liu, Huey-Xian Kelly Wong, et al.