Duncan NRI Faculty and Staff Publications
The Jan and Dan Duncan Neurological Institute is home to 37 Principal Investigators, more than 400+ scientists and 10 Core labs.
Dan and Duncan Neurological Institute also house the Gordon and Mary Cain Pediatric Neurology Research Foundation Laboratories which are focused on epilepsy research and Baylor College's of Medicine's Center for Drug Discovery which is aimed at quick identification and advancement of small molecules to clinical trials.
Since inception, more than 1700 scientific studies have been published, and more than 85 disease-causing genetic mutations have been discovered or co-discovered by our scientists. There are currently 6 active clinical trials and studies.
Submissions from 2024
Improving Access to Exome Sequencing in a Medically Underserved Population Through the Texome Project, Blake Vuocolo, Ryan J German, Seema R Lalani, et al.
Aging Fly Cell Atlas Identifies Exhaustive Aging Features at Cellular Resolution, Kenneth A Wilson, Sudipta Bar, Eric B Dammer, et al.
Astrocytic Slc4a4 Regulates Blood-Brain Barrier Integrity in Healthy and Stroke Brains via a CCL2-CCR2 Pathway and No Dysregulation, Qi Ye, Juyeon Jo, Chih-Yen Wang, et al.
Submissions from 2023
Loss of Neuron Navigator 2 Impairs Brain and Cerebellar Development, Andrea Accogli, Shenzhao Lu, Ilaria Musante, et al.
De Novo Variants in MRTFB Have Gain-of-Function Activity in Drosophila and Are Associated With a Novel Neurodevelopmental Phenotype With Dysmorphic Features, Jonathan C Andrews, Jung-Wan Mok, Oguz Kanca, et al.
De Novo Variants in MRTFB Have Gain-of-Function Activity in Drosophila and Are Associated With a Novel Neurodevelopmental Phenotype With Dysmorphic Features, Jonathan C Andrews, Jung-Wan Mok, Oguz Kanca, et al.
MeCP2 Regulates Gdf11, a Dosage-Sensitive Gene Critical for Neurological Function, Sameer S Bajikar, Ashley G Anderson, Jian Zhou, et al.
The Cerebellum Contributes to Generalized Seizures by Altering Activity in the Ventral Posteromedial Nucleus, Jaclyn Beckinghausen, Joshua Ortiz-Guzman, Tao Lin, et al.
Upregulation of the ESCRT Pathway and Multivesicular Bodies Accelerates Degradation of Proteins Associated With Neurodegeneration, Ron Benyair, Sai Srinivas Panapakkam Giridharan, Pilar Rivero-Ríos, et al.
Phase Separation in Biology and Disease; Current Perspectives and Open Questions, Steven Boeynaems, Shasha Chong, Jörg Gsponer, et al.
Poly(A)-Binding Protein Is an Ataxin-2 Chaperone That Regulates Biomolecular Condensates, Steven Boeynaems, Yanniv Dorone, Yanrong Zhuang, et al.
Functional Variants Identify Sex-Specific Genes and Pathways in Alzheimer’s Disease, Thomas Bourquard, Kwanghyuk Lee, Ismael Al-Ramahi, et al.
Cerebellar Dysfunction as a Source of Dystonic Phenotypes in Mice, Amanda M Brown, Meike E van der Heijden, H A Jinnah, et al.
Loss of the Batten Disease Protein CLN3 Leads to Mis-Trafficking of M6PR and Defective Autophagic-Lysosomal Reformation, Alessia Calcagni', Leopoldo Staiano, Nicolina Zampelli, et al.
RNA-Based Translation Activators for Targeted Gene Upregulation, Yang Cao, Huachun Liu, Shannon S Lu, et al.
Mass Spectrometry Imaging as an Emerging Tool for Studying Metabolism in Human Brain Organoids, Gerarda Cappuccio, Saleh M Khalil, Sivan Osenberg, et al.
EGR1 Drives Cell Proliferation by Directly Stimulating TFEB Transcription in Response to Starvation, Marcella Cesana, Gennaro Tufano, Francesco Panariello, et al.
Targeted Gene Expression Profiling Predicts Meningioma Outcomes and Radiotherapy Responses, William C Chen, Abrar Choudhury, Mark W Youngblood, et al.
Hypermitotic Meningiomas Harbor DNA Methylation Subgroups With Distinct Biological and Clinical Features, Abrar Choudhury, William C Chen, Calixto-Hope G Lucas, et al.
Very-Long-Chain Fatty Acids Induce Glial-Derived Sphingosine-1-Phosphate Synthesis, Secretion, and Neuroinflammation, Hyung-Lok Chung, Qi Ye, Ye-Jin Park, et al.
Disruption of the ATXN1-CIC Complex Reveals the Role of Additional Nuclear ATXN1 Interactors in Spinocerebellar Ataxia Type 1, Stephanie L Coffin, Mark A Durham, Larissa Nitschke, et al.
Structure of the Lysosomal mTORC1-TFEB-Rag-Ragulator Megacomplex, Zhicheng Cui, Gennaro Napolitano, Mariana E G de Araujo, et al.
Literature-Based Predictions of Mendelian Disease Therapies, Cole A Deisseroth, Won-Seok Lee, Jiyoen Kim, et al.
Alternative Polyadenylation Alters Protein Dosage by Switching Between Intronic and 3’UTR Sites, Nicola de Prisco, Caitlin Ford, Nathan D Elrod, et al.
TFEB and TFE3 Drive Kidney Cystogenesis and Tumorigenesis, Chiara Di Malta, Angela Zampelli, Letizia Granieri, et al.