The Jan and Dan Duncan Neurological Institute is home to 37 Principal Investigators, more than 400+ scientists and 10 Core labs.
Dan and Duncan Neurological Institute also house the Gordon and Mary Cain Pediatric Neurology Research Foundation Laboratories which are focused on epilepsy research and Baylor College's of Medicine's Center for Drug Discovery which is aimed at quick identification and advancement of small molecules to clinical trials.
Since inception, more than 1700 scientific studies have been published, and more than 85 disease-causing genetic mutations have been discovered or co-discovered by our scientists. There are currently 6 active clinical trials and studies.
Submissions from 2025
Loss of the Lysosomal Protein CLN3 Triggers C-Abl-Dependent YAP1 Pro-Apoptotic Signaling, Neuza Domingues, Alessia Calcagni', Sofia Freire, et al.
Cerebellar Purkinje Cell Stripe Patterns Reveal a Differential Vulnerability and Resistance to Cell Loss During Normal Aging in Mice, Sarah G Donofrio, Cheryl Brandenburg, Amanda M Brown, et al.
Low-Grade Glial/Glioneuronal Tumor With YAP1::FAM118B Fusion: A Novel Molecular Finding, Fouad El-Dana, Kenneth Aldape, Zied Abdullaev, et al.
Bridging Psychiatry and Rare Genetic Diseases: A Scoping Review of Therapeutic Strategies and Diagnostic Delay Paired With Healthcare Economic Burden Analysis, Sheldon R Garrison, Isaac J Siegel, Christopher R Takala, et al.
Recurrent Carotid Paragangliomas in a Syndromic Patient With a Heterozygous Missense Variant in DNA Methyltransferase 3 Alpha, Ryan J German, Blake Vuocolo, Liesbeth Vossaert, et al.
Time to Treatment in Pediatric Patients With Repeated Episodes of Status Epilepticus, Jennifer V Gettings, Iván Sánchez Fernández, Anne Anderson, et al.
Volumetric Changes in Cerebellar Transverse Zones: Age and Sex Effects in Health and Neurological Disorders, Farshid Ghiyamihoor, Payam Paymani, Jarrad Perron, et al.
MultiSite Assembly of Gateway Induced Clones (MAGIC): A Flexible Cloning Toolbox for Use in Vertebrate Model Systems, William B Gillespie, Yuwen Zhang, Oscar E Ruiz, et al.
Distinguishing PEX2 and PEX16 Gene Variant Severity for Mild, Severe and Atypical Peroxisome Biogenesis Disorders, Vanessa A Gomez, Oguz Kanca, Sharayu V Jangam, et al.
Synaptic Alterations in Pyramidal Cells Following Genetic Manipulation of Neuronal Excitability in Monkey Prefrontal Cortex, Guillermo Gonzalez-Burgos, Takeaki Miyamae, Yosuke Nishihata, et al.
Subacute Neuropathy Post-Liver Transplantation in Zellweger Spectrum Disorder: A Case Report, Clarissa Gonzalez, Madelyn J Cohen, Juhee Hong, et al.
Blue-Shifted Ancyromonad Channelrhodopsins for Multiplex Optogenetics, Elena G Govorunova, Oleg A Sineshchekov, Hai Li, et al.
The Effect of TERT Promoter Mutation on Predicting Meningioma Outcomes: A Multi-Institutional Cohort Analysis, Karenna J Groff, Ruchit V Patel, Yang Feng, et al.
Diverse Ancestral Representation Improves Genetic Intolerance Metrics, Alexander L Han, Chloe F Sands, Dorota Matelska, et al.
EZHIP Boosts Neuronal-Like Synaptic Gene Programs and Depresses Polyamine Metabolism, Elham Hasheminasabgorji, Huey-Miin Chen, Taylor A Gatesman, et al.
Characterizing Features Affecting Local Ancestry Inference Performance in Admixed Populations, Jessica Honorato-Mauer, Nirav N Shah, Adam X Maihofer, et al.
Enhanced Control of Liposomal Drug Release by Drug-Aptamer Complexes, Xiangang Huang, Yang Li, Matthew Torre, et al.
Current Controversies in Prenatal Diagnosis 2: Conventional Postmortem Examination Remains the Gold Standard for the Anatomical Examination of Fetal Loss, J Ciaran Hutchinson, Lorraine Potocki, and Ignatia B Van den Veyver
Resolving SLC6A1 Variable Expressivity With Deep Clinical Phenotyping and Drosophila Models, Kristy L Jay, Nikhita Gogate, Paige I Hall, et al.
Breaking the Synaptic Vesicle Cycle: Mechanistic Insights into Presynaptic Dysfunctions in Epilepsy, Kevin Jiang, Lu-Tang Yang, and Mingshan Xue
Molecular Logic for Cellular Specializations That Initiate the Auditory Parallel Processing Pathways, Junzhan Jing, Ming Hu, Tenzin Ngodup, et al.
Protocol for Unlocking Alternative Polyadenylation Insights From Bulk RNA-Seq Data With PolyAMiner-Bulk, Venkata Jonnakuti, Sriya Jonnakuti, and Hari Krishna Yalamanchili
Multi-Epitope Immunocapture of Huntingtin Reveals Striatum-Selective Molecular Signatures, Joshua L Justice, Todd M Greco, Josiah E Hutton, et al.
The Small GTPase Rap1 in POMC Neurons Regulates Leptin Actions and Glucose Metabolism, Kentaro Kaneko, Weisheng Lu, Yong Xu, et al.
Pleiotropy and the Increasing Complexity of Parkinson's Disease Genetics, Jonggeol Kim and Joshua M Shulman