The Jan and Dan Duncan Neurological Institute is home to 37 Principal Investigators, more than 400+ scientists and 10 Core labs.
Dan and Duncan Neurological Institute also house the Gordon and Mary Cain Pediatric Neurology Research Foundation Laboratories which are focused on epilepsy research and Baylor College's of Medicine's Center for Drug Discovery which is aimed at quick identification and advancement of small molecules to clinical trials.
Since inception, more than 1700 scientific studies have been published, and more than 85 disease-causing genetic mutations have been discovered or co-discovered by our scientists. There are currently 6 active clinical trials and studies.
Submissions from 2025
APOA1 Binding Protein Promotes Lymphatic Cell Fate and Lymphangiogenesis by Relieving Caveolae-Mediated Inhibition of VEGFR3 Signaling, Jun-Dae Kim, Surbhi Chaudhary, Weiqing Chen, et al.
Alpha-Synuclein Phosphomimetic Y39E and S129D Knock-In Mice Show Cytosolic Alpha-Synuclein Localization without Developing Neurodegeneration or Motor Deficits, YoungDoo Kim, Bhupesh Vaidya, Joseph McInnes, et al.
Improved Allele Frequencies in Gnomad Through Local Ancestry Inference, Pragati Kore, Michael W Wilson, Grace Tiao, et al.
PICALM Alzheimer’s Risk Allele Causes Aberrant Lipid Droplets in Microglia, Alena Kozlova, Siwei Zhang, Ari Sudwarts, et al.
Cell Type-Specific Purifying Selection of Synonymous Mitochondrial DNA Variation, Caleb A Lareau, Patrick Maschmeyer, Yajie Yin, et al.
An Open-Label Study Evaluating the Safety and Efficacy of AMO-01 for the Treatment of Seizures in Phelan-McDermid Syndrome, Tess Levy, J Lloyd Holder, Joseph P Horrigan, et al.
Unveiling Spatial Heterogeneity in Medulloblastoma: A Multi-Omics Analysis of Cellular State and Geographical Organization, Jiankang Li, Hailong Liu, Ziwei Wang, et al.
Lac-Phe Induces Hypophagia by Inhibiting AgRP Neurons in Mice, Hailan Liu, Veronica L Li, Qingzhuo Liu, et al.
A Protective Role of Src-1 Against Aging Associated Cognitive Decline, Hesong Liu, Yongjie Yang, Jonathan C Bean, et al.
Prolonged Exposure to Food Odors Suppresses Feeding via an Olfactory Bulb-to-Hypothalamus Circuit, Yao Liu, Hailan Liu, Huey-Xian Kelly Wong, et al.
Multi-Omics Delineate Growth Factor Network Underlying Exercise Effects in an Alzheimer’s Mouse Model, Xin Li, Chaozhong Liu, Wenbo Li, et al.
Retinal Ganglion Cell Migration and Viability Requires the Kinase LKB1, Robert D Mackin, Ritika V Bhalla, Viktor Akhanov, et al.
Advancements in Prenatal Genetic Screening and Testing: Emerging Technologies and Evolving Applications, Mona M Makhamreh, Mei Ling Chong, and Ignatia B Van den Veyver
Heterozygous Variants in PLCG1 Affect Hearing, Vision, Cardiac, and Immune Function, Mengqi Ma, Yiming Zheng, Mingxi Deng, et al.
Life on the Dry Side: A Roadmap to Understanding Desiccation Tolerance and Accelerating Translational Applications, R A Marks, J T B Ekwealor, M A S Artur, et al.
Common AAV Gene Therapy Vectors Show Nonselective Transduction of Ex Vivo Human Brain Tissue, J P McGinnis, Joshua Ortiz-Guzman, Maria Camila Guevara, et al.
Functional Assays in Drosophila Facilitate Classification of Variants of Uncertain Significance Associated With Rare Diseases, Jung-Wan Mok, Shelley B Gibson, Haley A Dostalik, et al.
C-Terminal Frameshift Variants in Gpkow Are Associated With a Multisystemic X-Linked Disorder, Jung-Wan Mok, Laura Mackay, Maria Blazo, et al.
Longitudinal Multi-Omics in Alpha-Synuclein Drosophila Model Discriminates Disease- From Age-Associated Pathologies in Parkinson’s Disease, Justin Moore, Timothy Wu, Justin Dhindsa, et al.
Adaptive Filters at the First Olfactory Synapse, Elizabeth H Moss and Benjamin R Arenkiel
Distinct Patterns of PV and SST GABAergic Neuronal Activity in the Basal Forebrain during Olfactory-Guided Behavior in Mice, Elizabeth H Moss, Evelyne K Tantry, Elaine Le, et al.
Survey and Improvement Strategies for Gene Prioritization With Large Language Models, Matthew B Neeley, Guantong Qi, Guanchu Wang, et al.
Thalamic Deep Brain Stimulation Improves Movement in a Cerebellar Model of Lesion-Based Status Dystonicus, Megan X Nguyen, Amanda M Brown, Tao Lin, et al.
A Targeted Gene Expression Biomarker Predicts Clinic Low-Risk Meningioma Recurrence, Minh P Nguyen, Ramin A Morshed, Mark W Youngblood, et al.
Glucose Uptake in Pigment Glia Suppresses Tau-Induced Inflammation and Photoreceptor Degeneration, Mikiko Oka, Sho Nakajima, Emiko Suzuki, et al.