The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases is a research institute that seeks to investigate the cause of human diseases at the cellular and molecular levels, using DNA and protein technologies to elucidate disease mechanisms.
Its development and progress are of particular interest for future planning in the increasingly important area of clinical research. The Institute endeavors to design methods of rational therapy and, wherever possible, strategies for the prevention of human diseases.
Submissions from 2023
AgRP Neurons Are Not Indispensable for Body Weight Maintenance in Adult Mice, Jing Cai, Jing Chen, Joshua Ortiz-Guzman, et al.
A Highly Selective Humanized DDR1 Mab Reverses Immune Exclusion by Disrupting Collagen Fiber Alignment in Breast Cancer, Junquan Liu, Huai-Chin Chiang, Wei Xiong, et al.
A Human Mitofusin 2 Mutation Can Cause Mitophagic Cardiomyopathy, Antonietta Franco, Jiajia Li, Daniel P Kelly, et al.
Allosteric Autoregulation of DNA Binding via a DNA-Mimicking Protein Domain: A Biophysical Study of ZNF410-DNA Interaction Using Small Angle X-Ray Scattering, Gundeep Kaur, Ren Ren, Michal Hammel, et al.
A Mendelian Randomization Study of Genetic Liability to Post-traumatic Stress Disorder and Risk of Ischemic Stroke, Opeyemi Soremekun, Clarisse Musanabaganwa, Annette Uwineza, et al.
An ACE2 Decamer Viral Trap as a Durable Intervention Solution for Current and Future SARS-COV, Hailong Guo, Bomsoo Cho, Paul R Hinton, et al.
An Antibody-Drug Conjugate Targeting Gpr56 Demonstrates Efficacy In Preclinical Models of Colorectal Cancer, Joan Jacob, Liezl E Francisco, Treena Chatterjee, et al.
An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis, Jun-Ichi Abe, Masaki Imanishi, Shengyu Li, et al.
Anoctamin 4 Channel Currents Activate Glucose-Inhibited Neurons in the Mouse Ventromedial Hypothalamus During Hypoglycemia, Longlong Tu, Jonathan C Bean, Yang He, et al.
A Novel GRK3-HDAC2 Regulatory Pathway Is a Key Direct Link Between Neuroendocrine Differentiation and Angiogenesis in Prostate Cancer Progression, Samira Naderinezhad, Guoliang Zhang, Zheng Wang, et al.
A Novel Humanized Chi3L1 Blocking Antibody Attenuates Acetaminophen-Induced Liver Injury In Mice, Leike Li, Yankai Wen, Daniel Wrapp, et al.
Anthocyanins: Molecular Aspects on Their Neuroprotective Activity, César A Zaa, Álvaro J Marcelo, Zhiqiang An, et al.
Antibody Therapies For The Treatment of Acute Myeloid Leukemia: Exploring Current and Emerging Therapeutic Targets, Joshua W Morse, Margarita Rios, John Ye, et al.
A Polycistronic System for Multiplexed and Precalibrated Expression of Multigene Pathways in Fungi, Qun Yue, Jie Meng, Yue Qiu, et al.
A Polygenic Risk Score for Alzheimer’s Disease Constructed Using Apoe-Region Variants Has Stronger Association Than Apoe Alleles With Mild Cognitive Impairment in Hispanic/Latino Adults in the U.S., Tamar Sofer, Nuzulul Kurniansyah, Einat Granot-Hershkovitz, et al.
A Potent and Broad Neutralization of SARS-Cov-2 Variants of Concern by DARpins, Vikas Chonira, Young D Kwon, Jason Gorman, et al.
Association Between Whole Blood-Derived Mitochondrial Dna Copy Number, Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk, Xue Liu, Xianbang Sun, Yuankai Zhang, et al.
Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function: A Meta-Analysis of Community-Based Cohorts, Yuankai Zhang, Xue Liu, Kerri L Wiggins, et al.
Association of Rare Protein-Truncating DNA Variants in APOB or PCSK9 With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease, Jacqueline S Dron, Aniruddh P Patel, Yiyi Zhang, et al.
Biochemical and Structural Characterization of the First-Discovered Metazoan DNA Cytosine-N4 Methyltransferase From the Bdelloid Rotifer Adineta vaga, Jujun Zhou, John R Horton, Gundeep Kaur, et al.
Cardiac Muscle-Restricted Partial Loss of Nos1ap Expression Has Limited but Significant Impact on Electrocardiographic Features, Alexa Smith, Dallas Auer, Morgan Johnson, et al.
Chromosome 10q2432 Variants Associate With Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study, Minghua Liu, Farid Khasiyev, Sanjeev Sariya, et al.
Circadian Rhythms As Modulators of Brain Health During Development and Throughout Aging, Rachel Van Drunen and Kristin Eckel-Mahan
Citrate Phosphate Dextrose Alters Coagulation Dynamics Ex Vivo, Jacob B Schriner, Atharwa Mankame, Scott D Olson, et al.
Clonal Hematopoiesis is Associated With Protection From Alzheimer's Disease, Hind Bouzid, Julia A Belk, Max Jan, et al.